iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000184677.16	ENST00000375647.4	ENSP00000364798.4
ENSG00000184677.16	ENST00000374651.8	ENSP00000363782.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.90e-08	35.6	24	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgklde 67
           +D+++ +g  +f+ahk+vLaa+S  F+ l+++       ++++ i+   v+pe f  ll+ +Ytgkl+ 
   Q: 24   CDCTISIGTIYFRAHKLVLAAASLLFKTLLDN-------TDTISIDAsvVSPEEFALLLEMMYTGKLPV 85
           8*****************************43.......8899999558*****************986 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein Sequence
(Fasta)

MELPNYSRQL LQQLYTLCKE QQFCDCTISI GTIYFRAHKL VLAAASLLFK TLLDNTDTIS 60
IDASVVSPEE FALLLEMMYT GKLPVGKHNF SKIISLADSL QMFDVAVSCK NLLTSLVNCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATACCCATT GCGCGCCGGC CTCAAGATGG CCGCCTTCTG GCGTCTCCGG CGCTGTTGAA 60
TGGCGAAAGC TTTATTGTTC CCTTCGGGCA GGAGTGTTCG TGTCCTCTAT GGCGCTGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011029--DEATH-like_dom
IPR011333--SKP1/BTB/POZ
IPR030404--ZBTB40
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0030282--P:bone mineralization
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9923

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001920	Ailuropoda melanoleuca	84.46	0.00e+00	2112.00
IUUC-Apl-003605	Anas platyrhynchos	43.31	1.00e-146	513.00
IUUC-Ame-011397	Astyanax mexicanus	35.60	5.00e-167	582.00
IUUC-Bta-012624	Bos taurus	83.05	0.00e+00	2032.00
IUUC-Cja-018947	Callithrix jacchus	93.64	0.00e+00	2333.00
IUUC-Cfa-020834	Canis familiaris	86.08	0.00e+00	2129.00
IUUC-Cpo-022231	Cavia porcellus	82.98	0.00e+00	1978.00
IUUC-Csa-023812	Chlorocebus sabaeus	96.37	0.00e+00	2416.00
IUUC-Cho-024798	Choloepus hoffmanni	79.15	0.00e+00	1369.00
IUUC-Dre-028535	Danio rerio	37.64	5.00e-158	551.00
IUUC-Dno-029544	Dasypus novemcinctus	86.80	0.00e+00	2145.00
IUUC-Ete-032390	Echinops telfairi	76.20	0.00e+00	1785.00
IUUC-Eca-033930	Equus caballus	82.61	0.00e+00	2004.00
IUUC-Fca-035364	Felis catus	77.63	0.00e+00	1374.00
IUUC-Gga-040492	Gallus gallus	53.10	0.00e+00	703.00
IUUC-Ggo-045476	Gorilla gorilla	98.47	0.00e+00	2447.00
IUUC-Lch-050586	Latimeria chalumnae	47.88	0.00e+00	1096.00
IUUC-Loc-052801	Lepisosteus oculatus	44.99	0.00e+00	805.00
IUUC-Laf-053711	Loxodonta africana	86.10	0.00e+00	2165.00
IUUC-Mcc-055818	Macaca mulatta	96.05	0.00e+00	2409.00
IUUC-Mga-059901	Meleagris gallopavo	62.33	0.00e+00	1422.00
IUUC-Mmr-060838	Microcebus murinus	87.34	0.00e+00	2159.00
IUUC-Mdo-061850	Monodelphis domestica	68.09	0.00e+00	1681.00
IUUC-Mmu-063124	Mus musculus	77.30	0.00e+00	1869.00
IUUC-Mpu-065753	Mustela putorius furo	83.74	0.00e+00	2003.00
IUUC-Mlu-066935	Myotis lucifugus	82.93	0.00e+00	2049.00
IUUC-Nle-070124	Nomascus leucogenys	97.50	0.00e+00	2440.00
IUUC-Opr-070923	Ochotona princeps	84.20	0.00e+00	1448.00
IUUC-Ont-071320	Oreochromis niloticus	49.70	3.00e-129	456.00
IUUC-Oan-073611	Ornithorhynchus anatinus	66.56	0.00e+00	1602.00
IUUC-Ocu-074805	Oryctolagus cuniculus	82.85	0.00e+00	1961.00
IUUC-Ola-087539	Oryzias latipes	67.52	3.00e-33	133.00
IUUC-Oga-088828	Otolemur garnettii	85.76	0.00e+00	2174.00
IUUC-Oar-089430	Ovis aries	82.32	0.00e+00	2027.00
IUUC-Ptr-090587	Pan troglodytes	98.55	0.00e+00	2468.00
IUUC-Pan-091889	Papio anubis	93.80	0.00e+00	1682.00
IUUC-Pab-098090	Pongo abelii	97.90	0.00e+00	2412.00
IUUC-Rno-104899	Rattus norvegicus	77.37	0.00e+00	1882.00
IUUC-Sha-106799	Sarcophilus harrisii	63.11	0.00e+00	1465.00
IUUC-Sar-113563	Sorex araneus	71.13	0.00e+00	1039.00
IUUC-Ssc-115845	Sus scrofa	80.96	0.00e+00	1967.00
IUUC-Tru-117975	Takifugu rubripes	53.27	8.00e-134	471.00
IUUC-Tsy-119438	Tarsius syrichta	76.87	0.00e+00	1278.00
IUUC-Ttr-128872	Tursiops truncatus	82.21	0.00e+00	1992.00
IUUC-Vpa-130652	Vicugna pacos	75.50	0.00e+00	1361.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence