iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Sce-106233

Ensembl Protein ID

YMR022W

UniProt Accession

Q02159; D6VZJ6; UBC7_YEAST

Genbank Protein ID

CAA47302.1; CAA48846.1; CAA89125.1; AAS56442.1; DAA09920.1

Protein Name

Ubiquitin-conjugating enzyme E2 7; E2 ubiquitin-conjugating enzyme 7; Ubiquitin carrier protein; Ubiquitin-conjugating enzyme E2-18 kDa; Ubiquitin-protein ligase

Genbank Nucleotide ID

X66829; X69100; Z49211; AY558116; BK006946

Gene Name

UBC7; QRI8; YMR022W; YM9711.12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YMR022W	YMR022W	YMR022W

Annotation

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	17310239; 19520858

Classification

Family	E-value	Score	Start	End
E2/UBC	7.00e-51	170.1	8	156

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...........eeek 91
           Rl kel++l kd+p+gi+a+p++e++++ w++li Gp+dtpY++gvF++++efp+dYP++PPk++f+ +i+hPn+y+nG+vC+sil+            ee+
   Q: 8    RLLKELQQLIKDSPPGIVAGPKSENNIFIWDCLIQGPPDTPYADGVFNAKLEFPKDYPLSPPKLTFTPSILHPNIYPNGEVCISILHspgddpnmyelAEER 109
           899***********************************************************************************88999999**999*** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           Wsp++sve++lls++s+l+epn+es++n +a+ l+++nr e++++v+
   Q: 110  WSPVQSVEKILLSVMSMLSEPNIESGANIDACILWRDNRPEFERQVK 156
           ********************************************997 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M). Involved in resistance to cadmium poisoning.

Protein Sequence
(Fasta)

MSKTAQKRLL KELQQLIKDS PPGIVAGPKS ENNIFIWDCL IQGPPDTPYA DGVFNAKLEF 60
PKDYPLSPPK LTFTPSILHP NIYPNGEVCI SILHSPGDDP NMYELAEERW SPVQSVEKIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAAAA CCGCTCAGAA ACGTCTCCTC AAGGAGCTTC AACAGTTAAT TAAAGATTCT 60
CCACCTGGTA TAGTGGCTGG TCCCAAATCG GAGAATAACA TATTCATTTG GGACTGCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0104--Cadmium
KW-0105--Cadmium resistance
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0882--Thioester bond
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006333--P:chromatin assembly or disassembly
GO:0031505--P:fungal-type cell wall organization
GO:0000209--P:protein polyubiquitination
GO:0046686--P:response to cadmium ion
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YMR022W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000411	Aegilops tauschii	39.20	2.00e-30	122.00
IUUC-Aml-002172	Ailuropoda melanoleuca	62.18	3.00e-52	195.00
IUUC-Atr-003150	Amborella trichopoda	59.46	3.00e-38	148.00
IUUC-Apl-003761	Anas platyrhynchos	60.37	1.00e-53	200.00
IUUC-Aca-005062	Anolis carolinensis	61.21	2.00e-54	202.00
IUUC-Aly-006282	Arabidopsis lyrata	55.71	7.00e-45	170.00
IUUC-Ath-007258	Arabidopsis thaliana	55.10	2.00e-38	149.00
IUUC-Ago-007853	Ashbya gossypii	81.82	8.00e-82	293.00
IUUC-Acl-008080	Aspergillus clavatus	61.45	1.00e-58	216.00
IUUC-Afl-008478	Aspergillus flavus	59.04	8.00e-57	210.00
IUUC-Afu-009051	Aspergillus fumigatus	61.45	1.00e-58	216.00
IUUC-Ani-009271	Aspergillus nidulans	62.76	5.00e-51	191.00
IUUC-Ang-009748	Aspergillus niger	60.24	1.00e-57	213.00
IUUC-Aor-010228	Aspergillus oryzae	59.04	1.00e-56	210.00
IUUC-Ate-010293	Aspergillus terreus	60.24	1.00e-57	213.00
IUUC-Ame-011698	Astyanax mexicanus	62.42	2.00e-57	212.00
IUUC-Bgr-012226	Blumeria graminis	57.32	2.00e-54	202.00
IUUC-Bta-013277	Bos taurus	65.85	4.00e-44	167.00
IUUC-Bci-013676	Botrytis cinerea	57.32	5.00e-55	204.00
IUUC-Bdi-014838	Brachypodium distachyon	53.25	4.00e-40	154.00
IUUC-Bol-016017	Brassica oleracea	58.57	2.00e-46	175.00
IUUC-Bra-017105	Brassica rapa	58.57	2.00e-46	175.00
IUUC-Cel-018676	Caenorhabditis elegans	57.67	2.00e-54	202.00
IUUC-Cja-019767	Callithrix jacchus	62.42	8.00e-57	210.00
IUUC-Cfa-020047	Canis familiaris	62.42	2.00e-56	209.00
IUUC-Cpo-021507	Cavia porcellus	62.42	9.00e-57	210.00
IUUC-Cre-022895	Chlamydomonas reinhardtii	53.80	3.00e-43	165.00
IUUC-Csa-023745	Chlorocebus sabaeus	61.64	1.00e-52	196.00
IUUC-Cin-025310	Ciona intestinalis	60.74	9.00e-57	210.00
IUUC-Csv-025961	Ciona savignyi	60.12	5.00e-56	207.00
IUUC-Cgl-026553	Colletotrichum gloeosporioides	59.26	6.00e-56	207.00
IUUC-Cne-026903	Cryptococcus neoformans	61.59	3.00e-51	191.00
IUUC-Cme-027321	Cyanidioschyzon merolae	52.15	7.00e-39	150.00
IUUC-Dre-027900	Danio rerio	62.42	2.00e-57	212.00
IUUC-Dno-029688	Dasypus novemcinctus	62.91	6.00e-52	194.00
IUUC-Dor-030686	Dipodomys ordii	47.97	2.00e-36	143.00
IUUC-Dse-031253	Dothistroma septosporum	59.39	2.00e-57	212.00
IUUC-Dme-031849	Drosophila melanogaster	60.61	1.00e-56	209.00
IUUC-Ete-033010	Echinops telfairi	62.42	2.00e-55	205.00
IUUC-Eca-033294	Equus caballus	62.18	1.00e-52	196.00
IUUC-Eeu-034947	Erinaceus europaeus	57.48	7.00e-33	130.00
IUUC-Fca-036442	Felis catus	63.97	2.00e-47	179.00
IUUC-Fal-037188	Ficedula albicollis	61.44	1.00e-51	193.00
IUUC-Fox-037762	Fusarium oxysporum	58.79	2.00e-57	212.00
IUUC-Fso-038181	Fusarium solani	57.58	1.00e-56	209.00
IUUC-Gmo-038663	Gadus morhua	60.00	1.00e-55	206.00
IUUC-Ggr-039808	Gaeumannomyces graminis	58.64	1.00e-55	206.00
IUUC-Gga-040355	Gallus gallus	61.82	2.00e-56	209.00
IUUC-Gac-041847	Gasterosteus aculeatus	61.82	2.00e-57	212.00
IUUC-Gma-044131	Glycine max	55.41	1.00e-33	133.00
IUUC-Ggo-045202	Gorilla gorilla	62.42	9.00e-57	210.00
IUUC-Hsa-046369	Homo sapiens	62.42	9.00e-57	210.00
IUUC-Hvu-047065	Hordeum vulgare	53.02	1.00e-38	150.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	62.42	6.00e-57	211.00
IUUC-Kpa-049317	Komagataella pastoris	67.28	3.00e-65	238.00
IUUC-Lch-049596	Latimeria chalumnae	62.34	3.00e-53	198.00
IUUC-Lpe-051124	Leersia perrieri	55.00	3.00e-38	149.00
IUUC-Loc-052346	Lepisosteus oculatus	65.04	6.00e-44	167.00
IUUC-Lma-053126	Leptosphaeria maculans	62.88	5.00e-49	184.00
IUUC-Laf-054560	Loxodonta africana	60.87	3.00e-53	198.00
IUUC-Mcc-055172	Macaca mulatta	62.42	9.00e-57	210.00
IUUC-Meu-056891	Macropus eugenii	61.78	1.00e-52	196.00
IUUC-Mor-057260	Magnaporthe oryzae	58.02	1.00e-55	206.00
IUUC-Mpo-057468	Magnaporthe poae	58.02	3.00e-55	205.00
IUUC-Mtr-058406	Medicago truncatula	56.76	3.00e-41	158.00
IUUC-Mla-059084	Melampsora laricipopulina	60.00	5.00e-57	211.00
IUUC-Mga-059939	Meleagris gallopavo	60.76	1.00e-52	196.00
IUUC-Mvi-060514	Microbotryum violaceum	62.58	1.00e-58	216.00
IUUC-Mmr-061029	Microcebus murinus	60.48	2.00e-52	195.00
IUUC-Mdo-061820	Monodelphis domestica	63.03	1.00e-57	213.00
IUUC-Mmu-063123	Mus musculus	62.42	9.00e-57	210.00
IUUC-Mac-065294	Musa acuminata	53.69	3.00e-39	152.00
IUUC-Mpu-065866	Mustela putorius furo	62.91	1.00e-51	193.00
IUUC-Mlu-067220	Myotis lucifugus	62.18	2.00e-52	195.00
IUUC-Nfi-068395	Neosartorya fischeri	61.45	1.00e-58	216.00
IUUC-Ncr-068623	Neurospora crassa	60.49	2.00e-56	209.00
IUUC-Nle-070007	Nomascus leucogenys	62.42	9.00e-57	210.00
IUUC-Opr-070958	Ochotona princeps	52.70	4.00e-41	158.00
IUUC-Ont-071736	Oreochromis niloticus	61.21	2.00e-56	209.00
IUUC-Oan-073475	Ornithorhynchus anatinus	59.51	4.00e-52	194.00
IUUC-Ocu-074820	Oryctolagus cuniculus	61.84	4.00e-52	194.00
IUUC-Oba-075915	Oryza barthii	55.71	6.00e-44	167.00
IUUC-Obr-076863	Oryza brachyantha	54.29	1.00e-37	146.00
IUUC-Ogl-076981	Oryza glaberrima	55.71	6.00e-44	167.00
IUUC-Ogu-078183	Oryza glumaepatula	55.71	6.00e-44	167.00
IUUC-Oin-079755	Oryza indica	55.71	6.00e-44	167.00
IUUC-Olo-080576	Oryza longistaminata	55.71	6.00e-44	167.00
IUUC-Ome-081190	Oryza meridionalis	52.35	1.00e-41	160.00
IUUC-Oni-083010	Oryza nivara	55.71	6.00e-44	167.00
IUUC-Opu-083784	Oryza punctata	55.00	4.00e-38	148.00
IUUC-Oru-084817	Oryza rufipogon	55.71	6.00e-44	167.00
IUUC-Osa-085291	Oryza sativa	55.71	6.00e-44	167.00
IUUC-Ola-087571	Oryzias latipes	60.61	1.00e-56	209.00
IUUC-Olu-087887	Ostreococcus lucimarinus	50.62	3.00e-45	172.00
IUUC-Oga-088473	Otolemur garnettii	50.97	4.00e-42	161.00
IUUC-Oar-089706	Ovis aries	62.42	8.00e-57	210.00
IUUC-Ptr-090798	Pan troglodytes	62.42	9.00e-57	210.00
IUUC-Pan-091967	Papio anubis	62.42	9.00e-57	210.00
IUUC-Psi-093524	Pelodiscus sinensis	62.91	6.00e-52	194.00
IUUC-Pma-094602	Petromyzon marinus	62.59	2.00e-48	181.00
IUUC-Pno-094979	Phaeosphaeria nodorum	60.61	1.00e-59	219.00
IUUC-Ppa-095965	Physcomitrella patens	53.09	2.00e-47	179.00
IUUC-Pfo-097330	Poecilia formosa	61.21	1.00e-56	209.00
IUUC-Pab-098225	Pongo abelii	62.42	2.00e-56	209.00
IUUC-Pop-099881	Populus trichocarpa	57.14	1.00e-44	170.00
IUUC-Pca-101040	Procavia capensis	62.91	6.00e-52	194.00
IUUC-Ppe-101407	Prunus persica	56.76	1.00e-40	156.00
IUUC-Pva-103074	Pteropus vampyrus	53.90	6.00e-41	158.00
IUUC-Pgr-103674	Puccinia graminis	57.40	1.00e-54	203.00
IUUC-Ptt-103840	Puccinia triticina	56.80	2.00e-54	202.00
IUUC-Pte-104389	Pyrenophora teres	61.21	2.00e-59	218.00
IUUC-Pyt-104703	Pyrenophora triticirepentis	61.82	8.00e-60	220.00
IUUC-Rno-105228	Rattus norvegicus	62.42	9.00e-57	210.00
IUUC-Sha-107274	Sarcophilus harrisii	60.61	4.00e-53	197.00
IUUC-Sja-107937	Schizosaccharomyces japonicus	62.05	1.00e-59	220.00
IUUC-Spo-108269	Schizosaccharomyces pombe	61.45	3.00e-59	218.00
IUUC-Ssl-108636	Sclerotinia sclerotiorum	57.93	2.00e-55	205.00
IUUC-Smo-109401	Selaginella moellendorffii	58.21	1.00e-35	139.00
IUUC-Sit-110784	Setaria italica	55.71	1.00e-38	150.00
IUUC-Sly-111177	Solanum lycopersicum	57.86	5.00e-41	157.00
IUUC-Stu-112598	Solanum tuberosum	57.86	5.00e-41	157.00
IUUC-Sbi-113787	Sorghum bicolor	52.15	7.00e-41	157.00
IUUC-Sre-114952	Sporisorium reilianum	56.29	5.00e-52	194.00
IUUC-Ssc-115365	Sus scrofa	61.69	3.00e-52	195.00
IUUC-Tgu-116816	Taeniopygia guttata	61.82	2.00e-56	209.00
IUUC-Tru-118443	Takifugu rubripes	51.30	7.00e-43	164.00
IUUC-Tsy-119168	Tarsius syrichta	53.90	9.00e-41	157.00
IUUC-Tni-120278	Tetraodon nigroviridis	59.64	5.00e-54	201.00
IUUC-Tca-121649	Theobroma cacao	53.09	4.00e-40	154.00
IUUC-Tre-122131	Trichoderma reesei	59.26	2.00e-57	212.00
IUUC-Tvi-122669	Trichoderma virens	58.64	3.00e-56	208.00
IUUC-Tae-123772	Triticum aestivum	54.55	3.00e-41	159.00
IUUC-Tur-126873	Triticum urartu	53.95	2.00e-40	157.00
IUUC-Tme-127052	Tuber melanosporum	64.81	2.00e-62	228.00
IUUC-Tbe-127792	Tupaia belangeri	62.42	9.00e-57	210.00
IUUC-Ttr-128609	Tursiops truncatus	53.90	6.00e-41	158.00
IUUC-Uma-129587	Ustilago maydis	56.89	1.00e-52	196.00
IUUC-Vda-129914	Verticillium dahliae	57.41	3.00e-55	205.00
IUUC-Vpa-130208	Vicugna pacos	52.70	3.00e-41	159.00
IUUC-Vvi-131387	Vitis vinifera	57.43	3.00e-40	155.00
IUUC-Xtr-132450	Xenopus tropicalis	61.21	2.00e-56	209.00
IUUC-Xma-133016	Xiphophorus maculatus	61.21	1.00e-56	209.00
IUUC-Yli-134379	Yarrowia lipolytica	64.20	2.00e-61	225.00
IUUC-Zma-135764	Zea mays	53.02	1.00e-38	150.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence