iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000184900.15	ENST00000397898.7	ENSP00000380995.3
ENSG00000184900.15	ENST00000332859.10	ENSP00000330343.6
ENSG00000184900.15	ENST00000397893.3	ENSP00000380990.3
ENSG00000184900.15	ENST00000411651.6	ENSP00000409666.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UBL/SUMO	SUMO	10692421; 24569813

Classification

Family	E-value	Score	Start	End
ULD/UBL/SUMO	2.30e-32	113.2	14	92
ULD/UDP/UBQ/UBQ_Other	6.80e-05	24.3	21	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 6    kapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
             +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l+++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 92
           689*****************************.**********************************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           v   dgs+ ++k++++++ ++L +   +++g+ ++q+r  ++G+++ + +t a++ + d++ti++ +++ 
   Q: 21   VAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQT 90
           5556899**********************************************************98875 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Protein Sequence
(Fasta)

MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR 60
FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVPESSLAG HSF 103

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCTGGGTT TGCCCGCGCT CGCCGACGTG GCGGCCTGGC CAAGCTCGGC GCCGCTCACC 60
AGCGCTGACC TGGGGGTGGT TTGACCTCCC AGTGCCTCAG TTTCTTCACA GGTAAAACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0031386--F:protein tag
GO:0070911--P:global genome nucleotide-excision repair
GO:0016925--P:protein sumoylation

KEGG

hsa:6612

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002090	Ailuropoda melanoleuca	95.74	5.00e-50	188.00
IUUC-Atr-002794	Amborella trichopoda	57.14	3.00e-20	89.70
IUUC-Aca-004778	Anolis carolinensis	98.92	2.00e-51	192.00
IUUC-Ani-009300	Aspergillus nidulans	48.72	2.00e-16	76.60
IUUC-Ang-009651	Aspergillus niger	51.28	4.00e-17	79.30
IUUC-Ate-010503	Aspergillus terreus	41.24	7.00e-15	72.40
IUUC-Ame-011304	Astyanax mexicanus	97.83	2.00e-50	189.00
IUUC-Bta-012492	Bos taurus	100.00	2.00e-51	193.00
IUUC-Bci-013625	Botrytis cinerea	47.06	2.00e-18	83.20
IUUC-Bdi-014847	Brachypodium distachyon	53.33	2.00e-21	93.60
IUUC-Bol-015122	Brassica oleracea	56.96	3.00e-21	93.20
IUUC-Bra-017377	Brassica rapa	56.96	3.00e-21	93.20
IUUC-Cja-019875	Callithrix jacchus	96.08	5.00e-55	205.00
IUUC-Cpo-022241	Cavia porcellus	98.92	3.00e-51	192.00
IUUC-Cre-022980	Chlamydomonas reinhardtii	43.96	2.00e-18	84.00
IUUC-Csa-023457	Chlorocebus sabaeus	91.26	5.00e-53	198.00
IUUC-Dre-027877	Danio rerio	98.91	8.00e-51	191.00
IUUC-Dme-031967	Drosophila melanogaster	71.28	1.00e-34	137.00
IUUC-Fca-036348	Felis catus	98.84	4.00e-47	179.00
IUUC-Gmo-039337	Gadus morhua	96.77	1.00e-50	190.00
IUUC-Gac-041576	Gasterosteus aculeatus	91.35	2.00e-51	193.00
IUUC-Gma-043091	Glycine max	49.50	1.00e-20	91.70
IUUC-Hvu-047514	Hordeum vulgare	51.55	4.00e-21	92.40
IUUC-Itr-048366	Ictidomys tridecemlineatus	94.62	2.00e-48	183.00
IUUC-Lch-050519	Latimeria chalumnae	90.22	7.00e-45	171.00
IUUC-Lpe-051129	Leersia perrieri	56.04	3.00e-24	102.00
IUUC-Loc-052130	Lepisosteus oculatus	97.85	7.00e-51	191.00
IUUC-Lma-052968	Leptosphaeria maculans	47.19	3.00e-18	83.20
IUUC-Mcc-054714	Macaca mulatta	69.66	2.00e-50	191.00
IUUC-Mor-057132	Magnaporthe oryzae	54.43	3.00e-20	90.10
IUUC-Mpo-057351	Magnaporthe poae	55.84	2.00e-20	90.10
IUUC-Mla-059051	Melampsora laricipopulina	45.65	3.00e-16	77.00
IUUC-Mvi-060478	Microbotryum violaceum	42.31	6.00e-12	62.00
IUUC-Mmr-061052	Microcebus murinus	95.88	1.00e-51	194.00
IUUC-Mmu-064045	Mus musculus	96.84	1.00e-49	187.00
IUUC-Mac-064821	Musa acuminata	57.14	3.00e-20	89.70
IUUC-Mpu-065686	Mustela putorius furo	97.78	3.00e-49	185.00
IUUC-Mlu-066949	Myotis lucifugus	97.67	9.00e-47	177.00
IUUC-Nfi-068364	Neosartorya fischeri	50.00	2.00e-17	80.10
IUUC-Nle-070043	Nomascus leucogenys	74.81	4.00e-51	193.00
IUUC-Ont-071659	Oreochromis niloticus	98.92	3.00e-51	192.00
IUUC-Oan-073080	Ornithorhynchus anatinus	97.75	5.00e-48	182.00
IUUC-Oba-075425	Oryza barthii	59.74	4.00e-22	95.90
IUUC-Obr-076884	Oryza brachyantha	61.04	1.00e-22	97.40
IUUC-Ogl-077346	Oryza glaberrima	59.74	4.00e-22	95.90
IUUC-Ogu-078983	Oryza glumaepatula	52.75	5.00e-21	93.60
IUUC-Oin-079503	Oryza indica	59.74	4.00e-22	95.90
IUUC-Olo-080573	Oryza longistaminata	59.74	4.00e-22	95.90
IUUC-Ome-081885	Oryza meridionalis	59.74	5.00e-22	95.90
IUUC-Oni-082762	Oryza nivara	59.74	4.00e-22	95.90
IUUC-Opu-083431	Oryza punctata	59.74	9.00e-22	96.70
IUUC-Oru-084392	Oryza rufipogon	59.74	4.00e-22	95.90
IUUC-Osa-086070	Oryza sativa	59.74	4.00e-22	95.90
IUUC-Ola-086379	Oryzias latipes	98.90	4.00e-50	189.00
IUUC-Oga-088989	Otolemur garnettii	96.91	3.00e-52	196.00
IUUC-Oar-089406	Ovis aries	98.84	1.00e-47	180.00
IUUC-Ptr-091447	Pan troglodytes	100.00	4.00e-58	215.00
IUUC-Pan-091728	Papio anubis	93.20	5.00e-54	201.00
IUUC-Pno-094884	Phaeosphaeria nodorum	46.67	2.00e-19	86.70
IUUC-Ppa-095772	Physcomitrella patens	52.22	5.00e-20	89.40
IUUC-Pfo-097413	Poecilia formosa	97.85	8.00e-51	191.00
IUUC-Pab-098618	Pongo abelii	98.96	1.00e-53	200.00
IUUC-Pop-099042	Populus trichocarpa	50.98	2.00e-21	93.60
IUUC-Ppe-101721	Prunus persica	56.41	2.00e-20	91.30
IUUC-Ptt-103986	Puccinia triticina	48.05	2.00e-14	70.90
IUUC-Pte-104358	Pyrenophora teres	47.25	5.00e-20	88.60
IUUC-Pyt-104485	Pyrenophora triticirepentis	47.25	5.00e-20	88.60
IUUC-Rno-105136	Rattus norvegicus	98.92	3.00e-51	192.00
IUUC-Sha-106682	Sarcophilus harrisii	96.59	7.00e-48	181.00
IUUC-Smo-109051	Selaginella moellendorffii	52.38	4.00e-21	92.80
IUUC-Sly-110855	Solanum lycopersicum	55.84	3.00e-20	89.70
IUUC-Stu-111935	Solanum tuberosum	51.72	1.00e-20	91.30
IUUC-Ssc-116092	Sus scrofa	98.91	7.00e-51	191.00
IUUC-Tru-118409	Takifugu rubripes	97.83	3.00e-50	188.00
IUUC-Tni-120059	Tetraodon nigroviridis	96.77	3.00e-50	189.00
IUUC-Tca-120927	Theobroma cacao	55.42	1.00e-21	95.10
IUUC-Vvi-130844	Vitis vinifera	53.49	2.00e-21	94.00
IUUC-Xtr-132678	Xenopus tropicalis	98.92	3.00e-51	192.00
IUUC-Xma-133518	Xiphophorus maculatus	98.92	2.00e-51	192.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence