iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045766

UUCD1 version

UUC-HoS-00045

Ensembl Protein ID

ENSP00000217173.2

UniProt Accession

O94941; Q6IAR5; Q86X87; Q9H4J2; RNF37_HUMAN

Genbank Protein ID

BAA74883.2; BAG51073.1; CAG33370.1; CAC09908.2; CAC09909.1; EAX10550.1; EAX10551.1; AAH00515.1; AAH46122.1

Protein Name

RING finger protein 37; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing protein 5; UbcM4-interacting protein 5; Ubiquitin-conjugating enzyme 7-interacting protein 5

Genbank Nucleotide ID

AB020667; AK022444; CR457089; AL121891; AL121891; CH471133; CH471133; BC000515; BC046122

Gene Name

UBOX5; KIAA0860; RNF37; UBCE7IP5; UIP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185019.16	ENST00000217173.6	ENSP00000217173.2
ENSG00000185019.16	ENST00000348031.6	ENSP00000311726.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
AREsite	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17050664
E3 activity/RING/U-box	U-box	17050664

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.20e-17	65.4	258	337
E3 activity/RING/RING	0.0088	18.2	483	528

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.....tcPvtrqplteedl.vPnltlrrliqawceenss 74
           +vpeefl+pI+le+M +P+ lpsG ++d+s++ek+ +s  +     ++P+t+  +t++++  P+ +l++ i++++ ++s+
   Q: 258  DVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEATwgrvpSDPFTGVAFTPHSQpLPHPSLKARIDHFLLQHSI 337
           69*********************************8888889*************999888****************986 PP

E3 activity/RING/RING

   S: 1    CaiCledf.....kdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca C+  f     k++++ lpCgH+ ++ Cl +k        s   +C  C+
   Q: 483  CASCKRVFspyfkKEPVYQLPCGHLLCRPCLgEKQ------RSLPMTCTACQ 528
           999*888888898888999***********96555......88888898886 PP

Organism

Homo sapiens

Functional Description
(View)

May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.

Protein Sequence
(Fasta)

MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN 60
VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGTATTT TTAGTAGAGA CGGGGGTTTC ACCACGTTAG CCAGGCTGGT CTCGAACTCC 60
TGAACTCAGG TGATCCGCCC GCCTTGGCCT CCCAAAGTAC TGGGATTACA GGCGTGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008979--Galactose-bd-like
IPR003613--Ubox_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51698--U_BOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF04564--U-box

SMART

SM00504--Ubox

Gene Ontology

GO:0005925--C:focal adhesion
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031625--F:ubiquitin protein ligase binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0000209--P:protein polyubiquitination

KEGG

hsa:22888

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001702	Ailuropoda melanoleuca	89.83	0.00e+00	981.00
IUUC-Apl-003809	Anas platyrhynchos	61.64	0.00e+00	660.00
IUUC-Ame-011326	Astyanax mexicanus	41.38	1.00e-64	240.00
IUUC-Bgr-012106	Blumeria graminis	25.00	2.10e-02	35.40
IUUC-Bta-012836	Bos taurus	82.99	0.00e+00	858.00
IUUC-Cja-018735	Callithrix jacchus	94.27	0.00e+00	1028.00
IUUC-Cfa-020914	Canis familiaris	89.65	0.00e+00	977.00
IUUC-Cpo-022397	Cavia porcellus	81.89	0.00e+00	916.00
IUUC-Csa-023033	Chlorocebus sabaeus	94.90	0.00e+00	940.00
IUUC-Cho-025050	Choloepus hoffmanni	82.78	3.00e-149	521.00
IUUC-Cin-025271	Ciona intestinalis	26.20	4.00e-23	101.00
IUUC-Csv-025960	Ciona savignyi	27.80	2.00e-24	105.00
IUUC-Dre-028494	Danio rerio	34.88	3.00e-63	236.00
IUUC-Dno-029134	Dasypus novemcinctus	70.65	1.00e-167	582.00
IUUC-Dme-032212	Drosophila melanogaster	28.53	2.00e-29	124.00
IUUC-Eca-033535	Equus caballus	89.46	0.00e+00	981.00
IUUC-Fca-036298	Felis catus	89.71	0.00e+00	988.00
IUUC-Fal-037385	Ficedula albicollis	62.57	0.00e+00	650.00
IUUC-Gmo-039572	Gadus morhua	64.38	2.00e-22	100.00
IUUC-Gga-040207	Gallus gallus	62.98	0.00e+00	688.00
IUUC-Gac-042339	Gasterosteus aculeatus	40.88	2.00e-55	210.00
IUUC-Ggo-044710	Gorilla gorilla	98.89	0.00e+00	1098.00
IUUC-Itr-048280	Ictidomys tridecemlineatus	88.54	0.00e+00	993.00
IUUC-Lch-050587	Latimeria chalumnae	48.07	1.00e-131	462.00
IUUC-Laf-053430	Loxodonta africana	82.07	0.00e+00	879.00
IUUC-Mcc-055661	Macaca mulatta	97.78	0.00e+00	1085.00
IUUC-Meu-055959	Macropus eugenii	59.81	4.00e-175	607.00
IUUC-Mga-059505	Meleagris gallopavo	62.98	0.00e+00	683.00
IUUC-Mmr-061218	Microcebus murinus	89.83	0.00e+00	963.00
IUUC-Mdo-062113	Monodelphis domestica	68.37	0.00e+00	724.00
IUUC-Mmu-063349	Mus musculus	79.30	0.00e+00	838.00
IUUC-Mpu-066189	Mustela putorius furo	82.26	0.00e+00	859.00
IUUC-Mlu-067083	Myotis lucifugus	87.08	0.00e+00	970.00
IUUC-Nle-069481	Nomascus leucogenys	93.00	2.00e-135	476.00
IUUC-Opr-070674	Ochotona princeps	82.08	0.00e+00	894.00
IUUC-Ont-071995	Oreochromis niloticus	38.34	2.00e-84	306.00
IUUC-Oan-073003	Ornithorhynchus anatinus	63.65	1.00e-180	626.00
IUUC-Ocu-073834	Oryctolagus cuniculus	88.35	0.00e+00	941.00
IUUC-Ola-086469	Oryzias latipes	34.96	2.00e-66	246.00
IUUC-Oga-088316	Otolemur garnettii	86.44	0.00e+00	817.00
IUUC-Oar-089563	Ovis aries	85.66	0.00e+00	954.00
IUUC-Ptr-091293	Pan troglodytes	99.45	0.00e+00	1105.00
IUUC-Pan-092705	Papio anubis	97.43	0.00e+00	1081.00
IUUC-Psi-093111	Pelodiscus sinensis	64.64	0.00e+00	691.00
IUUC-Pfo-096603	Poecilia formosa	38.65	1.00e-30	128.00
IUUC-Pab-098636	Pongo abelii	95.13	0.00e+00	948.00
IUUC-Pca-100109	Procavia capensis	66.36	0.00e+00	664.00
IUUC-Pva-103028	Pteropus vampyrus	90.20	0.00e+00	962.00
IUUC-Ptt-103949	Puccinia triticina	36.96	9.20e-02	32.00
IUUC-Rno-104883	Rattus norvegicus	79.11	0.00e+00	829.00
IUUC-Sha-107133	Sarcophilus harrisii	56.78	8.00e-177	613.00
IUUC-Ssc-116252	Sus scrofa	79.70	0.00e+00	865.00
IUUC-Tgu-117163	Taeniopygia guttata	63.12	0.00e+00	665.00
IUUC-Tru-118541	Takifugu rubripes	35.69	9.00e-76	278.00
IUUC-Tsy-119281	Tarsius syrichta	82.06	0.00e+00	630.00
IUUC-Tni-120789	Tetraodon nigroviridis	38.89	7.00e-74	271.00
IUUC-Ttr-128555	Tursiops truncatus	90.57	0.00e+00	991.00
IUUC-Xtr-132303	Xenopus tropicalis	54.84	2.00e-162	566.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence