iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052389

Ensembl Protein ID

ENSLOCP00000020388.1

UniProt Accession

W5NIC9; W5NIC9_LEPOC

Genbank Protein ID

ENSLOCP00000020388

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

AHAT01001702

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000016503.1	ENSLOCT00000020423.1	ENSLOCP00000020388.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	6.90e-19	67.7	6	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           +k++v++++ + f++e++ed ++ +lKe +ak++gvp++q+ +I+aGk+L  d tL+++++ ++s+vh+v+
   Q: 6    LKVFVRFNSNHGFPVELDEDASIFHLKEVVAKQRGVPAQQLHVIFAGKELGSDCTLQSCDLPQQSTVHVVL 76
           589****99999*********************************************************97 PP

Organism

Lepisosteus oculatus

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

MLKIILKVFV RFNSNHGFPV ELDEDASIFH LKEVVAKQRG VPAQQLHVIF AGKELGSDCT 60
LQSCDLPQQS TVHVVLCSSS HTEKPDSGGA SGGALQRPLP QGVDSLTRVD LSTSRLPAHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGCTGTA AAGTGTTTTT TTTTTTCATG CATAGGAGCT CTGGAGTACG TTATCTCAGA 60
CTGCTTGTAA ATAAAGACCC CAGTAATTGG TCTCGATCAA TTTGCATATT CAAACAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0051865--P:protein autoubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	64.01	4.00e-101	360.00
IUUC-Apl-003304	Anas platyrhynchos	72.78	1.00e-150	525.00
IUUC-Aca-004908	Anolis carolinensis	65.42	1.00e-42	164.00
IUUC-Ame-011856	Astyanax mexicanus	70.54	0.00e+00	673.00
IUUC-Bta-013014	Bos taurus	65.67	2.00e-150	525.00
IUUC-Cel-018687	Caenorhabditis elegans	27.89	2.00e-40	160.00
IUUC-Cja-019274	Callithrix jacchus	62.71	1.00e-97	349.00
IUUC-Cfa-020461	Canis familiaris	60.27	6.00e-99	353.00
IUUC-Cpo-022251	Cavia porcellus	61.09	4.00e-98	350.00
IUUC-Csa-023112	Chlorocebus sabaeus	63.36	5.00e-92	330.00
IUUC-Cho-024504	Choloepus hoffmanni	49.46	9.00e-112	397.00
IUUC-Dre-028202	Danio rerio	68.60	5.00e-180	623.00
IUUC-Dno-028946	Dasypus novemcinctus	59.26	6.00e-35	138.00
IUUC-Dor-030508	Dipodomys ordii	57.22	2.00e-104	372.00
IUUC-Dme-031980	Drosophila melanogaster	42.71	3.00e-106	378.00
IUUC-Ete-032281	Echinops telfairi	50.87	2.00e-63	236.00
IUUC-Eca-033228	Equus caballus	60.54	2.00e-97	348.00
IUUC-Fal-037507	Ficedula albicollis	66.88	0.00e+00	641.00
IUUC-Gmo-038744	Gadus morhua	61.32	2.00e-97	348.00
IUUC-Gga-040353	Gallus gallus	65.58	0.00e+00	637.00
IUUC-Gac-042519	Gasterosteus aculeatus	53.81	3.00e-143	501.00
IUUC-Hsa-046016	Homo sapiens	65.25	1.00e-172	598.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	63.97	3.00e-163	568.00
IUUC-Mcc-054933	Macaca mulatta	66.24	4.00e-174	603.00
IUUC-Meu-055963	Macropus eugenii	53.07	4.00e-111	394.00
IUUC-Mpo-057509	Magnaporthe poae	47.06	9.00e-11	60.80
IUUC-Mga-059626	Meleagris gallopavo	73.33	8.00e-29	117.00
IUUC-Mmr-061566	Microcebus murinus	73.97	5.00e-83	300.00
IUUC-Mdo-062933	Monodelphis domestica	80.56	5.00e-30	121.00
IUUC-Mmu-063561	Mus musculus	66.17	0.00e+00	627.00
IUUC-Mpu-065799	Mustela putorius furo	61.77	5.00e-99	353.00
IUUC-Mlu-068134	Myotis lucifugus	61.26	8.00e-117	413.00
IUUC-Nle-070078	Nomascus leucogenys	62.05	3.00e-100	357.00
IUUC-Opr-070541	Ochotona princeps	65.01	2.00e-162	565.00
IUUC-Ont-071743	Oreochromis niloticus	59.13	7.00e-144	503.00
IUUC-Oan-073700	Ornithorhynchus anatinus	77.78	1.00e-20	90.50
IUUC-Ola-086426	Oryzias latipes	65.14	2.00e-67	247.00
IUUC-Oga-088867	Otolemur garnettii	67.74	6.00e-174	603.00
IUUC-Oar-089365	Ovis aries	65.01	1.00e-131	462.00
IUUC-Ptr-091371	Pan troglodytes	65.46	3.00e-172	597.00
IUUC-Pan-092443	Papio anubis	63.36	3.00e-98	351.00
IUUC-Psi-093851	Pelodiscus sinensis	60.17	2.00e-78	285.00
IUUC-Pfo-097194	Poecilia formosa	54.86	8.00e-141	493.00
IUUC-Pab-097999	Pongo abelii	54.39	4.00e-93	334.00
IUUC-Pca-100410	Procavia capensis	61.43	1.00e-145	509.00
IUUC-Pva-102300	Pteropus vampyrus	58.04	4.00e-144	504.00
IUUC-Rno-105556	Rattus norvegicus	63.57	1.00e-99	355.00
IUUC-Sha-106992	Sarcophilus harrisii	79.63	7.00e-22	94.70
IUUC-Sar-113121	Sorex araneus	81.03	9.00e-53	200.00
IUUC-Ssc-116435	Sus scrofa	62.93	3.00e-99	354.00
IUUC-Tgu-117489	Taeniopygia guttata	66.09	0.00e+00	633.00
IUUC-Tru-117927	Takifugu rubripes	54.18	2.00e-150	525.00
IUUC-Tsy-119372	Tarsius syrichta	71.08	3.00e-135	474.00
IUUC-Tni-120043	Tetraodon nigroviridis	53.83	2.00e-138	485.00
IUUC-Tbe-127539	Tupaia belangeri	56.75	5.00e-140	490.00
IUUC-Ttr-129149	Tursiops truncatus	61.83	2.00e-171	595.00
IUUC-Vpa-130439	Vicugna pacos	48.81	7.00e-119	420.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence