iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000023826.14	ENSMUST00000191124.6	ENSMUSP00000140587.1
ENSMUSG00000023826.14	ENSMUST00000186406.1	ENSMUSP00000140217.1
ENSMUSG00000023826.14	ENSMUST00000179624.7	ENSMUSP00000136268.1
ENSMUSG00000023826.14	ENSMUST00000168593.8	ENSMUSP00000127455.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	12826399; 20064468

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	7.00e-23	81.5	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           m ++v+++++  f++ev++d+++ +lKe +ak++gvp++q+++I+aGk+L ++ t+++++++++s+vh+v++++
   Q: 1    MIVFVRFNSSYGFPVEVDSDTSILQLKEVVAKRQGVPADQLRVIFAGKELPNHLTVQNCDLEQQSIVHIVQRPR 74
           89********************************************************************9986 PP

Organism

Mus musculus

Functional Description
(View)

Functional Description

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30. Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Protein Sequence
(Fasta)

MIVFVRFNSS YGFPVEVDSD TSILQLKEVV AKRQGVPADQ LRVIFAGKEL PNHLTVQNCD 60
LEQQSIVHIV QRPRRRSHET NASGGDEPQS TSEGSIWESR SLTRVDLSSH TLPVDSVGLA 120

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Nucleotide Sequence
(Fasta)

GATGACTAAA CCTGACAGAA ACGCTGGTGG GAGGCTCGGG CGGGCGCCAG TGCCCGCGTA 60
GGTCCTTCTC GACCCGCAGC CACCACCCGC CCGGTGACCA TGATAGGTAC GTGGGTGCCT 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0702--S-nitrosylation
KW-0770--Synapse
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0003779--F:actin binding
GO:0008013--F:beta-catenin binding
GO:0051087--F:chaperone binding
GO:0097602--F:cullin family protein binding
GO:0019899--F:enzyme binding
GO:1990444--F:F-box domain binding
GO:0001664--F:G-protein coupled receptor binding
GO:0031072--F:heat shock protein binding
GO:0042826--F:histone deacetylase binding
GO:0030544--F:Hsp70 protein binding
GO:0042802--F:identical protein binding
GO:0019900--F:kinase binding
GO:0046872--F:metal ion binding
GO:0030165--F:PDZ domain binding
GO:0043274--F:phospholipase binding
GO:0019901--F:protein kinase binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0015631--F:tubulin binding
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0044257--P:cellular protein catabolic process
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0007626--P:locomotory behavior
GO:0000423--P:macromitophagy
GO:0000266--P:mitochondrial fission
GO:0007005--P:mitochondrion organization
GO:0099074--P:mitochondrion to lysosome transport
GO:0000422--P:mitophagy
GO:0050804--P:modulation of synaptic transmission
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0060548--P:negative regulation of cell death
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0010629--P:negative regulation of gene expression
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:0046329--P:negative regulation of JNK cascade
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0043524--P:negative regulation of neuron apoptotic process
GO:1901215--P:negative regulation of neuron death
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0070050--P:neuron cellular homeostasis
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0010628--P:positive regulation of gene expression
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0090141--P:positive regulation of mitochondrial fission
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0010498--P:proteasomal protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0019538--P:protein metabolic process
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010506--P:regulation of autophagy
GO:1900407--P:regulation of cellular response to oxidative stress
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0010821--P:regulation of mitochondrion organization
GO:0046928--P:regulation of neurotransmitter secretion
GO:0031647--P:regulation of protein stability
GO:0031396--P:regulation of protein ubiquitination
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0034976--P:response to endoplasmic reticulum stress
GO:0006979--P:response to oxidative stress
GO:0001964--P:startle response
GO:0001963--P:synaptic transmission, dopaminergic
GO:0035249--P:synaptic transmission, glutamatergic
GO:0006351--P:transcription, DNA-templated
GO:0055069--P:zinc ion homeostasis

KEGG

mmu:50873

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	77.35	5.00e-130	456.00
IUUC-Apl-003304	Anas platyrhynchos	78.70	3.00e-160	557.00
IUUC-Aca-004908	Anolis carolinensis	74.07	3.00e-48	182.00
IUUC-Ame-011856	Astyanax mexicanus	63.07	2.00e-174	605.00
IUUC-Bta-013014	Bos taurus	79.49	0.00e+00	652.00
IUUC-Cel-018687	Caenorhabditis elegans	27.44	4.00e-43	168.00
IUUC-Cja-019274	Callithrix jacchus	80.21	3.00e-134	470.00
IUUC-Cfa-020461	Canis familiaris	76.39	2.00e-129	454.00
IUUC-Cpo-022251	Cavia porcellus	80.28	3.00e-137	480.00
IUUC-Csa-023112	Chlorocebus sabaeus	79.86	4.00e-126	444.00
IUUC-Cho-024504	Choloepus hoffmanni	58.01	2.00e-140	491.00
IUUC-Dre-028202	Danio rerio	62.15	5.00e-162	564.00
IUUC-Dno-028946	Dasypus novemcinctus	70.48	6.00e-41	158.00
IUUC-Dor-030508	Dipodomys ordii	72.70	6.00e-140	490.00
IUUC-Dme-031980	Drosophila melanogaster	43.61	4.00e-109	388.00
IUUC-Ete-032281	Echinops telfairi	63.45	2.00e-83	303.00
IUUC-Eca-033228	Equus caballus	77.51	5.00e-131	460.00
IUUC-Fca-036045	Felis catus	57.69	8.00e-17	78.20
IUUC-Fal-037507	Ficedula albicollis	70.97	0.00e+00	694.00
IUUC-Gmo-038744	Gadus morhua	59.65	1.00e-94	340.00
IUUC-Gga-040353	Gallus gallus	70.58	0.00e+00	682.00
IUUC-Gac-042519	Gasterosteus aculeatus	50.00	1.00e-132	466.00
IUUC-Hsa-046016	Homo sapiens	83.66	0.00e+00	789.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	83.12	0.00e+00	769.00
IUUC-Loc-052389	Lepisosteus oculatus	66.17	3.00e-173	601.00
IUUC-Laf-053412	Loxodonta africana	57.30	2.00e-23	100.00
IUUC-Mcc-054933	Macaca mulatta	84.30	0.00e+00	794.00
IUUC-Meu-055963	Macropus eugenii	61.12	2.00e-129	455.00
IUUC-Mga-059626	Meleagris gallopavo	78.67	3.00e-31	125.00
IUUC-Mmr-061566	Microcebus murinus	88.64	8.00e-101	359.00
IUUC-Mdo-061952	Monodelphis domestica	88.14	5.00e-30	121.00
IUUC-Mpu-065799	Mustela putorius furo	76.39	1.00e-124	439.00
IUUC-Mlu-068134	Myotis lucifugus	74.44	7.00e-148	516.00
IUUC-Ncr-068949	Neurospora crassa	35.11	5.00e-12	63.20
IUUC-Nle-070078	Nomascus leucogenys	79.26	6.00e-138	483.00
IUUC-Opr-070541	Ochotona princeps	81.60	0.00e+00	726.00
IUUC-Ont-071743	Oreochromis niloticus	51.83	7.00e-134	470.00
IUUC-Oan-073700	Ornithorhynchus anatinus	83.33	1.00e-22	97.10
IUUC-Ola-086426	Oryzias latipes	59.77	1.00e-60	224.00
IUUC-Oga-088867	Otolemur garnettii	83.37	0.00e+00	773.00
IUUC-Oar-089365	Ovis aries	79.11	2.00e-165	574.00
IUUC-Ptr-091371	Pan troglodytes	83.66	0.00e+00	787.00
IUUC-Pan-092443	Papio anubis	80.21	4.00e-133	467.00
IUUC-Psi-093851	Pelodiscus sinensis	61.22	6.00e-83	300.00
IUUC-Pfo-097194	Poecilia formosa	50.97	2.00e-132	465.00
IUUC-Pab-097999	Pongo abelii	68.57	4.00e-128	451.00
IUUC-Pca-100410	Procavia capensis	72.71	2.00e-177	615.00
IUUC-Pva-102300	Pteropus vampyrus	71.21	0.00e+00	634.00
IUUC-Rno-105556	Rattus norvegicus	93.43	2.00e-160	558.00
IUUC-Sha-106992	Sarcophilus harrisii	88.89	7.00e-24	101.00
IUUC-Ssl-108406	Sclerotinia sclerotiorum	24.89	4.00e-09	56.20
IUUC-Sar-113121	Sorex araneus	89.66	5.00e-59	221.00
IUUC-Ssc-116435	Sus scrofa	75.00	7.00e-126	442.00
IUUC-Tgu-117489	Taeniopygia guttata	70.56	0.00e+00	689.00
IUUC-Tru-117927	Takifugu rubripes	52.35	2.00e-141	496.00
IUUC-Tsy-119372	Tarsius syrichta	87.12	2.00e-170	592.00
IUUC-Tni-120043	Tetraodon nigroviridis	50.00	8.00e-130	457.00
IUUC-Tre-122176	Trichoderma reesei	43.08	7.00e-09	56.20
IUUC-Tvi-122588	Trichoderma virens	24.14	9.00e-11	62.40
IUUC-Tbe-127539	Tupaia belangeri	72.73	0.00e+00	657.00
IUUC-Ttr-129149	Tursiops truncatus	77.42	0.00e+00	749.00
IUUC-Vpa-130439	Vicugna pacos	59.70	4.00e-153	534.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence