iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	12750381; 16689637; 17543868

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	7.30e-07	27.1	258	276
UBD/Alpha-Helix/UIM	2.6e-05	13.3	301	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           dE+e++++A++lSl+E ++
   Q: 258  DEEELIRKAIELSLKESRN 276
           7***************875 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +Ed++L  A+++Sl E+ee
   Q: 301  EEDPDLKAAIQESLREAEE 319
           7****************98 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. Controls exit from the prevacuolar compartment (PVC) in both the forward direction to the vacuole and the return to the Golgi. Allows VPS10 to return to the (trans-Golgi network) TGN from the PVC. Might also function as an alternate adapter in the COPIb clathrin-like coat.

Protein Sequence
(Fasta)

MSVSTPSELD ALIEQATSES IPNGDLDLPI ALEISDVLRS RRVNPKDSMR CIKKRILNTA 60
DNPNTQLSSW KLTNICVKNG GTPFIKEICS REFMDTMEHV ILREDSNEEL SELVKTILYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCGTTA GCACGCCAAG TGAGTTAGAC GCATTAATAG AACAAGCCAC TAGTGAGAGC 60
ATTCCCAACG GTGACCTTGA TCTCCCCATA GCGTTGGAAA TTTCAGATGT GTTAAGATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0967--Endosome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF02809--UIM
PF00790--VHS

SMART

SM00064--FYVE
SM00726--UIM
SM00288--VHS

Gene Ontology

GO:0005768--C:endosome
GO:0010008--C:endosome membrane
GO:0033565--C:ESCRT-0 complex
GO:0046872--F:metal ion binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0043130--F:ubiquitin binding
GO:1904669--P:ATP export
GO:0045324--P:late endosome to vacuole transport
GO:0045053--P:protein retention in Golgi apparatus
GO:0006623--P:protein targeting to vacuole

KEGG

sce:YNR006W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001175	Aegilops tauschii	45.59	3.00e-14	70.10
IUUC-Aml-001518	Ailuropoda melanoleuca	28.44	5.00e-26	110.00
IUUC-Atr-002790	Amborella trichopoda	45.76	4.00e-13	68.90
IUUC-Apl-003662	Anas platyrhynchos	29.95	2.00e-24	105.00
IUUC-Aca-004940	Anolis carolinensis	29.07	2.00e-27	115.00
IUUC-Aly-006019	Arabidopsis lyrata	37.66	3.00e-12	65.90
IUUC-Ath-006781	Arabidopsis thaliana	38.96	6.00e-13	68.20
IUUC-Ago-007931	Ashbya gossypii	50.32	2.00e-135	474.00
IUUC-Acl-008274	Aspergillus clavatus	34.48	1.00e-73	268.00
IUUC-Afl-008521	Aspergillus flavus	35.89	8.00e-75	273.00
IUUC-Afu-008774	Aspergillus fumigatus	35.48	9.00e-74	269.00
IUUC-Ani-009445	Aspergillus nidulans	33.11	4.00e-75	273.00
IUUC-Ang-009863	Aspergillus niger	36.78	2.00e-73	268.00
IUUC-Ate-010444	Aspergillus terreus	36.08	4.00e-67	246.00
IUUC-Ame-011111	Astyanax mexicanus	29.96	5.00e-28	117.00
IUUC-Bgr-012087	Blumeria graminis	33.77	2.00e-65	241.00
IUUC-Bta-012506	Bos taurus	28.63	1.00e-27	116.00
IUUC-Bci-013782	Botrytis cinerea	33.73	7.00e-68	249.00
IUUC-Bdi-014421	Brachypodium distachyon	49.18	2.00e-14	70.90
IUUC-Bol-015456	Brassica oleracea	40.26	7.00e-14	71.20
IUUC-Bra-016882	Brassica rapa	40.26	2.00e-13	65.10
IUUC-Cel-018493	Caenorhabditis elegans	30.94	5.00e-28	117.00
IUUC-Cja-019998	Callithrix jacchus	28.12	3.00e-24	105.00
IUUC-Cfa-020615	Canis familiaris	28.19	7.00e-27	114.00
IUUC-Cpo-022019	Cavia porcellus	28.19	3.00e-27	115.00
IUUC-Csa-023596	Chlorocebus sabaeus	28.19	4.00e-27	114.00
IUUC-Cin-025488	Ciona intestinalis	30.84	9.00e-31	126.00
IUUC-Csv-025802	Ciona savignyi	27.91	8.00e-24	102.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	33.67	3.00e-71	260.00
IUUC-Cne-026847	Cryptococcus neoformans	32.20	8.00e-56	209.00
IUUC-Dre-028353	Danio rerio	29.22	4.00e-28	117.00
IUUC-Dno-029005	Dasypus novemcinctus	28.44	5.00e-27	114.00
IUUC-Dor-030280	Dipodomys ordii	28.57	4.00e-27	114.00
IUUC-Dse-031238	Dothistroma septosporum	34.70	3.00e-65	241.00
IUUC-Dme-031952	Drosophila melanogaster	33.04	5.00e-30	124.00
IUUC-Ete-032235	Echinops telfairi	28.77	2.00e-26	112.00
IUUC-Eca-033873	Equus caballus	28.25	9.00e-27	113.00
IUUC-Eeu-034820	Erinaceus europaeus	32.62	2.00e-15	75.50
IUUC-Fca-036563	Felis catus	28.63	1.00e-27	116.00
IUUC-Fal-036649	Ficedula albicollis	29.08	2.00e-25	108.00
IUUC-Fox-037962	Fusarium oxysporum	34.76	7.00e-63	233.00
IUUC-Fso-038396	Fusarium solani	35.02	2.00e-69	255.00
IUUC-Gmo-039510	Gadus morhua	29.46	5.00e-29	120.00
IUUC-Ggr-039938	Gaeumannomyces graminis	32.27	7.00e-60	223.00
IUUC-Gga-040201	Gallus gallus	29.22	4.00e-28	117.00
IUUC-Gac-041459	Gasterosteus aculeatus	29.22	1.00e-28	119.00
IUUC-Gma-042952	Glycine max	42.65	2.00e-16	77.00
IUUC-Ggo-044573	Gorilla gorilla	28.19	6.00e-27	114.00
IUUC-Hsa-046009	Homo sapiens	28.19	3.00e-27	115.00
IUUC-Hvu-047612	Hordeum vulgare	45.59	1.00e-14	71.20
IUUC-Itr-049065	Ictidomys tridecemlineatus	28.57	3.00e-27	114.00
IUUC-Kpa-049327	Komagataella pastoris	33.77	4.00e-72	263.00
IUUC-Lch-050236	Latimeria chalumnae	26.91	7.00e-17	78.60
IUUC-Lpe-051694	Leersia perrieri	45.76	1.00e-12	66.60
IUUC-Loc-051850	Lepisosteus oculatus	28.77	8.00e-26	110.00
IUUC-Lma-053252	Leptosphaeria maculans	35.94	5.00e-69	253.00
IUUC-Laf-053346	Loxodonta africana	28.57	4.00e-27	114.00
IUUC-Mcc-055789	Macaca mulatta	28.19	6.00e-27	114.00
IUUC-Meu-056329	Macropus eugenii	24.77	2.00e-16	79.00
IUUC-Mor-057205	Magnaporthe oryzae	33.27	1.00e-68	252.00
IUUC-Mpo-057295	Magnaporthe poae	32.32	2.00e-63	235.00
IUUC-Mtr-058217	Medicago truncatula	42.65	7.00e-08	48.90
IUUC-Mla-058849	Melampsora laricipopulina	38.57	3.00e-40	158.00
IUUC-Mga-059361	Meleagris gallopavo	30.10	3.00e-27	115.00
IUUC-Mvi-060561	Microbotryum violaceum	29.16	1.00e-48	186.00
IUUC-Mmr-061122	Microcebus murinus	28.57	5.00e-27	114.00
IUUC-Mdo-062171	Monodelphis domestica	28.38	4.00e-27	114.00
IUUC-Mmu-063952	Mus musculus	28.19	4.00e-27	114.00
IUUC-Mac-065112	Musa acuminata	33.07	6.00e-06	42.40
IUUC-Mpu-065852	Mustela putorius furo	28.57	5.00e-27	114.00
IUUC-Nfi-068539	Neosartorya fischeri	35.18	1.00e-74	272.00
IUUC-Ncr-068726	Neurospora crassa	34.81	1.00e-68	251.00
IUUC-Nle-070148	Nomascus leucogenys	25.45	4.00e-19	88.20
IUUC-Opr-070833	Ochotona princeps	36.36	9.00e-19	86.70
IUUC-Ont-071261	Oreochromis niloticus	28.77	7.00e-26	110.00
IUUC-Ocu-074133	Oryctolagus cuniculus	44.44	6.00e-16	77.40
IUUC-Oba-075700	Oryza barthii	45.76	2.00e-12	66.60
IUUC-Obr-076725	Oryza brachyantha	49.18	9.00e-08	48.50
IUUC-Ogl-077741	Oryza glaberrima	54.55	3.00e-06	43.50
IUUC-Ogu-078974	Oryza glumaepatula	54.55	4.00e-06	43.50
IUUC-Oin-079245	Oryza indica	54.55	3.00e-06	43.90
IUUC-Olo-080646	Oryza longistaminata	45.76	1.00e-12	67.00
IUUC-Ome-081286	Oryza meridionalis	54.55	8.00e-07	45.10
IUUC-Oni-082038	Oryza nivara	54.55	4.00e-06	43.50
IUUC-Opu-083654	Oryza punctata	54.55	3.00e-06	43.90
IUUC-Oru-084701	Oryza rufipogon	56.25	3.00e-06	43.50
IUUC-Osa-086159	Oryza sativa	54.55	3.00e-06	43.50
IUUC-Ola-087570	Oryzias latipes	28.63	1.00e-22	99.40
IUUC-Oga-089087	Otolemur garnettii	29.19	2.00e-23	102.00
IUUC-Oar-089534	Ovis aries	28.19	2.00e-27	115.00
IUUC-Ptr-091654	Pan troglodytes	27.23	1.00e-21	96.30
IUUC-Pan-092652	Papio anubis	28.19	5.00e-27	114.00
IUUC-Pma-094728	Petromyzon marinus	51.85	7.00e-15	74.70
IUUC-Pno-095125	Phaeosphaeria nodorum	35.55	1.00e-64	238.00
IUUC-Ppa-095369	Physcomitrella patens	49.18	7.00e-17	79.00
IUUC-Pfo-096757	Poecilia formosa	29.02	6.00e-25	107.00
IUUC-Pab-097788	Pongo abelii	28.19	6.00e-27	113.00
IUUC-Pop-099314	Populus trichocarpa	44.83	5.00e-13	68.60
IUUC-Pca-100145	Procavia capensis	27.68	2.00e-19	89.00
IUUC-Ppe-101769	Prunus persica	54.72	2.00e-16	77.40
IUUC-Pva-102965	Pteropus vampyrus	29.07	2.00e-27	115.00
IUUC-Pgr-103609	Puccinia graminis	39.59	5.00e-37	146.00
IUUC-Ptt-103940	Puccinia triticina	38.10	5.00e-32	130.00
IUUC-Pte-104095	Pyrenophora teres	33.26	7.00e-64	236.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	34.76	2.00e-64	238.00
IUUC-Rno-105125	Rattus norvegicus	28.57	1.00e-26	112.00
IUUC-Sha-107066	Sarcophilus harrisii	28.38	5.00e-27	114.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	34.03	6.00e-57	213.00
IUUC-Spo-108220	Schizosaccharomyces pombe	36.82	3.00e-68	250.00
IUUC-Ssl-108413	Sclerotinia sclerotiorum	39.05	4.00e-25	105.00
IUUC-Smo-109642	Selaginella moellendorffii	48.28	8.00e-16	75.50
IUUC-Sit-109755	Setaria italica	50.82	3.00e-15	73.60
IUUC-Sly-111265	Solanum lycopersicum	40.00	6.00e-07	44.70
IUUC-Stu-112464	Solanum tuberosum	37.66	3.00e-13	69.30
IUUC-Sar-113393	Sorex araneus	28.65	2.00e-16	78.60
IUUC-Sbi-114775	Sorghum bicolor	49.18	2.00e-14	70.90
IUUC-Sre-114986	Sporisorium reilianum	37.61	2.00e-42	166.00
IUUC-Ssc-115258	Sus scrofa	46.03	8.00e-15	73.90
IUUC-Tgu-117505	Taeniopygia guttata	29.85	3.00e-27	114.00
IUUC-Tru-118494	Takifugu rubripes	29.22	3.00e-28	118.00
IUUC-Tni-120174	Tetraodon nigroviridis	29.68	7.00e-29	120.00
IUUC-Tca-121349	Theobroma cacao	62.96	5.00e-06	43.10
IUUC-Tre-122191	Trichoderma reesei	34.36	8.00e-69	253.00
IUUC-Tvi-122318	Trichoderma virens	34.97	4.00e-71	260.00
IUUC-Tae-122898	Triticum aestivum	45.59	3.00e-14	70.50
IUUC-Tur-126023	Triticum urartu	44.78	1.00e-13	68.20
IUUC-Tme-126914	Tuber melanosporum	35.28	2.00e-70	258.00
IUUC-Tbe-127875	Tupaia belangeri	44.44	2.00e-14	73.20
IUUC-Ttr-129095	Tursiops truncatus	28.19	2.00e-27	115.00
IUUC-Uma-129475	Ustilago maydis	36.07	5.00e-39	154.00
IUUC-Vda-129908	Verticillium dahliae	29.67	1.00e-52	199.00
IUUC-Vpa-130696	Vicugna pacos	50.00	2.00e-14	73.60
IUUC-Vvi-131456	Vitis vinifera	55.56	4.00e-05	39.70
IUUC-Xtr-131900	Xenopus tropicalis	29.02	3.00e-26	111.00
IUUC-Xma-133124	Xiphophorus maculatus	29.46	3.00e-25	108.00
IUUC-Yli-134682	Yarrowia lipolytica	37.58	7.00e-74	269.00
IUUC-Zma-135288	Zea mays	45.07	2.00e-15	73.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence