iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185482.7	ENST00000332782.6	ENSP00000329200.2
ENSG00000185482.7	ENST00000557176.5	ENSP00000450740.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-15	58.9	248	305

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +++ +ly ++a ++d+L +  G++++vi  ++ +e+W++g  +  +k G+fP nF+ +++
   Q: 248  QSHYFVALYRFKALEKDDLDFPPGEKITVI--DDSNEEWWRG--KIGEKVGFFPPNFIIRVR 305
           578999************************..999*******..8*************9986 PP

Organism

Homo sapiens

Functional Description
(View)

In skeletal muscles contraction, may play a role in neuromuscular synaptic transmission.

Protein Sequence
(Fasta)

MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG EAVGAGGGPI 60
YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP KFCDVCARMI VLNNKFGLRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGTCATT TCAGCCCTGA CACCAAGGCA GGAGGCTAGG AGGTCTACAA ATAGCGACTG 60
GGTAGCTGGT GTGAACACAG GGGGTACTGG GGGGGCTTAG CCCCCAAGGA AGAGGACCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002219--PE/DAG-bd
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0035556--P:intracellular signal transduction
GO:0007274--P:neuromuscular synaptic transmission
GO:0003009--P:skeletal muscle contraction
GO:0048741--P:skeletal muscle fiber development

KEGG

hsa:246329

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001628	Ailuropoda melanoleuca	96.70	2.00e-177	614.00
IUUC-Apl-003476	Anas platyrhynchos	75.54	1.00e-145	509.00
IUUC-Aca-004927	Anolis carolinensis	73.32	1.00e-126	446.00
IUUC-Bta-013019	Bos taurus	96.43	6.00e-175	606.00
IUUC-Cja-019413	Callithrix jacchus	97.80	3.00e-179	620.00
IUUC-Cfa-020850	Canis familiaris	96.43	3.00e-180	624.00
IUUC-Cpo-022550	Cavia porcellus	95.60	3.00e-174	604.00
IUUC-Csa-023317	Chlorocebus sabaeus	99.18	0.00e+00	631.00
IUUC-Cho-024370	Choloepus hoffmanni	82.94	4.00e-121	427.00
IUUC-Dre-027776	Danio rerio	63.16	2.00e-104	372.00
IUUC-Dno-030075	Dasypus novemcinctus	94.51	3.00e-178	617.00
IUUC-Dor-030293	Dipodomys ordii	89.29	3.00e-153	534.00
IUUC-Dme-032167	Drosophila melanogaster	39.50	2.00e-21	99.00
IUUC-Eca-034242	Equus caballus	96.70	0.00e+00	650.00
IUUC-Eeu-035253	Erinaceus europaeus	85.16	4.00e-154	537.00
IUUC-Fal-036603	Ficedula albicollis	71.22	1.00e-120	426.00
IUUC-Gmo-038819	Gadus morhua	65.03	1.00e-99	356.00
IUUC-Gac-041411	Gasterosteus aculeatus	62.85	8.00e-92	330.00
IUUC-Ggo-045153	Gorilla gorilla	99.45	0.00e+00	634.00
IUUC-Itr-047869	Ictidomys tridecemlineatus	94.52	3.00e-169	587.00
IUUC-Lch-050210	Latimeria chalumnae	66.58	2.00e-127	448.00
IUUC-Loc-052713	Lepisosteus oculatus	67.59	3.00e-118	418.00
IUUC-Laf-053842	Loxodonta africana	95.60	9.00e-172	595.00
IUUC-Mcc-054677	Macaca mulatta	98.90	0.00e+00	631.00
IUUC-Meu-055955	Macropus eugenii	76.65	1.00e-119	422.00
IUUC-Mmr-060715	Microcebus murinus	96.15	2.00e-165	575.00
IUUC-Mmu-063329	Mus musculus	89.04	1.00e-147	515.00
IUUC-Mpu-066119	Mustela putorius furo	97.25	4.00e-178	617.00
IUUC-Mlu-068094	Myotis lucifugus	95.60	0.00e+00	630.00
IUUC-Nle-069394	Nomascus leucogenys	99.18	0.00e+00	631.00
IUUC-Opr-070364	Ochotona princeps	100.00	2.00e-70	259.00
IUUC-Ont-072682	Oreochromis niloticus	65.34	1.00e-94	339.00
IUUC-Ocu-074004	Oryctolagus cuniculus	97.97	9.00e-168	582.00
IUUC-Ola-087262	Oryzias latipes	65.84	6.00e-92	330.00
IUUC-Oga-088079	Otolemur garnettii	82.56	6.00e-128	449.00
IUUC-Oar-089375	Ovis aries	96.43	2.00e-175	607.00
IUUC-Ptr-091572	Pan troglodytes	99.45	0.00e+00	635.00
IUUC-Pan-091976	Papio anubis	98.35	0.00e+00	628.00
IUUC-Pma-094461	Petromyzon marinus	43.25	2.00e-66	245.00
IUUC-Pfo-096226	Poecilia formosa	64.11	8.00e-94	337.00
IUUC-Pab-097731	Pongo abelii	97.73	4.00e-119	422.00
IUUC-Pca-100482	Procavia capensis	94.51	8.00e-171	592.00
IUUC-Pva-102329	Pteropus vampyrus	88.82	6.00e-129	453.00
IUUC-Rno-105196	Rattus norvegicus	89.86	1.00e-148	519.00
IUUC-Sha-106995	Sarcophilus harrisii	89.59	7.00e-153	533.00
IUUC-Sar-113724	Sorex araneus	87.15	3.00e-79	288.00
IUUC-Ssc-115771	Sus scrofa	96.46	2.00e-177	615.00
IUUC-Tru-118166	Takifugu rubripes	65.03	1.00e-99	356.00
IUUC-Tsy-119347	Tarsius syrichta	96.15	8.00e-176	609.00
IUUC-Tni-120179	Tetraodon nigroviridis	70.24	3.00e-115	408.00
IUUC-Ttr-128506	Tursiops truncatus	95.61	9.00e-175	605.00
IUUC-Xtr-131834	Xenopus tropicalis	74.69	3.00e-126	444.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence