iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046931

UUCD1 version

UUC-HoS-01093

Ensembl Protein ID

ENSP00000358474.1

UniProt Accession

P46736; A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; Q16107; Q53YX5; Q9BTZ6; BRCC3_HUMAN

Genbank Protein ID

CAA45917.1; AAB29005.2; AAR30498.1; BAG60999.1; BAG61237.1; BAG36320.1; CAH70537.1; CAH70537.1; CAH70538.1; CAH70538.1; CAI41654.1; CAI41654.1; CAI41655.1; CAI41655.1; CAO03573.1; CAO03574.1; CAO03575.1; CAO03575.1; CAO03576.1; CAO03576.1; CAO03601.1; CAO03601.1; CAO03602.1; CAO03602.1; AAH02999.1; AAH06540.1

Protein Name

Lys-63-specific deubiquitinase BRCC36; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36

Genbank Nucleotide ID

X64643; S68015; AY438030; AK298886; AK299194; AK313544; BX293995; BX470111; BX293995; BX470111; BX470111; BX293995; BX470111; BX293995; BX470111; BX470111; BX470111; BX293995; BX470111; BX293995; BX293995; BX470111; BX293995; BX470111; BC002999; BC006540

Gene Name

BRCC3; BRCC36; C6.1A; CXorf53

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185515.14	ENST00000340647.8	ENSP00000344103.4
ENSG00000185515.14	ENST00000330045.11	ENSP00000328641.7
ENSG00000185515.14	ENST00000369459.6	ENSP00000358471.2
ENSG00000185515.14	ENST00000369462.5	ENSP00000358474.1
ENSG00000185515.14	ENST00000411985.5	ENSP00000413170.1
ENSG00000185515.14	ENST00000453705.1	ENSP00000415152.1
ENSG00000185515.14	ENST00000399026.1	ENSP00000381988.1
ENSG00000185515.14	ENST00000399042.4	ENSP00000381998.2
ENSG00000185515.14	ENST00000620502.4	ENSP00000482836.1
ENSG00000185515.14	ENST00000630295.1	ENSP00000486287.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/JAMM	JAMM	20032457

Organism

Homo sapiens

Functional Description
(View)

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).

Protein Sequence
(Fasta)

MAVQVVQAVQ AVHLESDAFL VCLNHALSTE KEEVMGLCIG ELNDDTRSDS KFAYTGTEMR 60
TVAEKVDAVR IVHIHSVIIL RRSDKRKDRV EISPEQLSAA STEAERLAEL TGRPMRVVGW 120

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Nucleotide Sequence
(Fasta)

AGGCCTGGGC GGAGCGCACA GCGCTGGGCG CTGGGGAGGC TGCGCCGCAG CACCCGGTTG 60
GTCAGGACCA AGTGGGCCCG AGGCGGACGT GAGAAGGGTC GGGCCAAGAT GGCGGTGCAG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom
IPR033860--MPN_BRCC36

Pfam

PF01398--JAB

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0070552--C:BRISC complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000152--C:nuclear ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0030234--F:enzyme regulator activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0031593--F:polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0051301--P:cell division
GO:0006302--P:double-strand break repair
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0031572--P:G2 DNA damage checkpoint
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045739--P:positive regulation of DNA repair
GO:0016579--P:protein deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0010212--P:response to ionizing radiation
GO:0010165--P:response to X-ray

KEGG

hsa:79184

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cfa-020651	Canis familiaris	99.15	6.00e-53	199.00
IUUC-Eca-033703	Equus caballus	96.48	7.00e-149	520.00
IUUC-Fca-035771	Felis catus	89.05	5.00e-139	487.00
IUUC-Lch-050069	Latimeria chalumnae	80.71	3.00e-126	444.00
IUUC-Meu-056347	Macropus eugenii	50.44	2.00e-53	202.00
IUUC-Mdo-061933	Monodelphis domestica	69.39	3.00e-110	391.00
IUUC-Mpu-065997	Mustela putorius furo	98.56	1.00e-150	525.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence