iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000187961.13	ENST00000338591.7	ENSP00000343930.3
ENSG00000187961.13	ENST00000466300.1	ENSP00000463694.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	17062563

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	5.90e-21	76.3	92	156
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.00e-13	48.0	191	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D++l+v+ +e++ahk+vLa++S++F+a+f++e++es+ +  v+++d++p+++ +l++F Yt ++ 
   Q: 92   CDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR-QTHVTLHDIDPQALDQLVQFAYTAEIV 156
           8*************************************.***********************9986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi+ fAd+++c+dL +aa++++l+hF
   Q: 191  PSNCLGIRGFADAHSCSDLLKAAHRYVLQHF 221
           89***************************** PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).

Protein Sequence
(Fasta)

MQPRSERPAG RTQSPEHGSP GPGPEAPPPP PPQPPAPEAE RTRPRQARPA APMEGAVQLL 60
SREGHSVAHN SKRHYHDAFV AMSRMRQRGL LCDIVLHVAA KEIRAHKVVL ASCSPYFHAM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGAGCGAC ACAGAGCGGG CCGCCACCGC CGAGCAGCCC TCCGGCAGTC TCCGCGTCCG 60
TTAAGCCCGC GGGTCCTCCG CGAATCGGCG GTGGGTCCGG CAGCCGAATG CAGCCCCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0472--Membrane
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030054--C:cell junction
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0032839--C:dendrite cytoplasm
GO:0005615--C:extracellular space
GO:0043025--C:neuronal cell body
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0051015--F:actin filament binding
GO:0032947--F:protein complex scaffold
GO:0030036--P:actin cytoskeleton organization
GO:0007420--P:brain development
GO:0016567--P:protein ubiquitination

KEGG

hsa:339451

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002095	Ailuropoda melanoleuca	98.26	0.00e+00	1128.00
IUUC-Apl-003315	Anas platyrhynchos	79.90	0.00e+00	937.00
IUUC-Aca-005317	Anolis carolinensis	89.80	0.00e+00	1073.00
IUUC-Ame-010707	Astyanax mexicanus	89.74	0.00e+00	1058.00
IUUC-Bta-012531	Bos taurus	96.50	0.00e+00	1146.00
IUUC-Bra-017070	Brassica rapa	30.85	4.00e-17	83.20
IUUC-Cfa-021138	Canis familiaris	95.22	0.00e+00	1151.00
IUUC-Cpo-021432	Cavia porcellus	96.01	0.00e+00	1192.00
IUUC-Csa-023772	Chlorocebus sabaeus	99.65	0.00e+00	1155.00
IUUC-Dre-028401	Danio rerio	89.74	0.00e+00	1058.00
IUUC-Dno-029729	Dasypus novemcinctus	94.88	0.00e+00	1101.00
IUUC-Dor-030659	Dipodomys ordii	97.91	0.00e+00	1120.00
IUUC-Dme-031996	Drosophila melanogaster	56.17	0.00e+00	647.00
IUUC-Ete-033128	Echinops telfairi	92.24	0.00e+00	855.00
IUUC-Eca-033856	Equus caballus	97.22	0.00e+00	1105.00
IUUC-Eeu-034646	Erinaceus europaeus	92.64	0.00e+00	1033.00
IUUC-Fca-036183	Felis catus	97.74	0.00e+00	1120.00
IUUC-Fal-037046	Ficedula albicollis	81.21	0.00e+00	865.00
IUUC-Gmo-039526	Gadus morhua	83.07	0.00e+00	965.00
IUUC-Gga-040510	Gallus gallus	91.33	0.00e+00	1075.00
IUUC-Gac-042529	Gasterosteus aculeatus	86.93	0.00e+00	1046.00
IUUC-Ggo-044992	Gorilla gorilla	100.00	0.00e+00	1212.00
IUUC-Itr-048791	Ictidomys tridecemlineatus	95.37	0.00e+00	1152.00
IUUC-Lch-049449	Latimeria chalumnae	90.09	0.00e+00	1063.00
IUUC-Loc-052690	Lepisosteus oculatus	84.99	0.00e+00	1046.00
IUUC-Laf-053925	Loxodonta africana	96.29	0.00e+00	702.00
IUUC-Mcc-054780	Macaca mulatta	89.49	0.00e+00	1080.00
IUUC-Meu-056812	Macropus eugenii	84.72	0.00e+00	826.00
IUUC-Mpo-057526	Magnaporthe poae	27.50	3.00e-07	48.50
IUUC-Mga-059704	Meleagris gallopavo	90.85	0.00e+00	1076.00
IUUC-Mmr-061724	Microcebus murinus	95.45	0.00e+00	1130.00
IUUC-Mmu-063886	Mus musculus	96.01	0.00e+00	1147.00
IUUC-Mpu-066774	Mustela putorius furo	98.26	0.00e+00	1128.00
IUUC-Nle-070159	Nomascus leucogenys	99.68	0.00e+00	1209.00
IUUC-Opr-070367	Ochotona princeps	90.32	0.00e+00	822.00
IUUC-Ont-071757	Oreochromis niloticus	89.04	0.00e+00	1051.00
IUUC-Ocu-074674	Oryctolagus cuniculus	90.70	0.00e+00	1021.00
IUUC-Ola-086760	Oryzias latipes	87.44	0.00e+00	1049.00
IUUC-Oga-088570	Otolemur garnettii	93.95	0.00e+00	1142.00
IUUC-Oar-090344	Ovis aries	85.58	0.00e+00	992.00
IUUC-Ptr-090946	Pan troglodytes	99.84	0.00e+00	1210.00
IUUC-Pan-092661	Papio anubis	99.65	0.00e+00	1155.00
IUUC-Psi-094009	Pelodiscus sinensis	88.05	0.00e+00	1043.00
IUUC-Ppa-095956	Physcomitrella patens	27.38	4.00e-16	79.70
IUUC-Pfo-097164	Poecilia formosa	83.71	0.00e+00	1039.00
IUUC-Pab-097554	Pongo abelii	69.74	0.00e+00	754.00
IUUC-Pca-100460	Procavia capensis	87.30	0.00e+00	1016.00
IUUC-Pva-102180	Pteropus vampyrus	97.61	0.00e+00	1150.00
IUUC-Rno-105907	Rattus norvegicus	96.01	0.00e+00	1147.00
IUUC-Smo-109299	Selaginella moellendorffii	27.16	5.00e-16	79.70
IUUC-Sar-113112	Sorex araneus	82.88	1.00e-180	625.00
IUUC-Ssc-115448	Sus scrofa	90.77	0.00e+00	829.00
IUUC-Tgu-117293	Taeniopygia guttata	91.22	0.00e+00	1077.00
IUUC-Tru-117814	Takifugu rubripes	87.18	0.00e+00	1030.00
IUUC-Tni-120531	Tetraodon nigroviridis	89.22	0.00e+00	1054.00
IUUC-Tca-120913	Theobroma cacao	34.26	9.00e-36	145.00
IUUC-Tae-124075	Triticum aestivum	33.84	7.00e-40	159.00
IUUC-Tbe-127460	Tupaia belangeri	98.36	0.00e+00	1078.00
IUUC-Ttr-129301	Tursiops truncatus	93.84	1.00e-137	483.00
IUUC-Xtr-132356	Xenopus tropicalis	91.30	0.00e+00	1073.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence