iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000188039.13	ENST00000518676.5	ENSP00000428224.1
ENSG00000188039.13	ENST00000524140.6	ENSP00000428579.2
ENSG00000188039.13	ENST00000549814.5	ENSP00000447548.1
ENSG00000188039.13	ENST00000438489.6	ENSP00000400248.2
ENSG00000188039.13	ENST00000552788.1	ENSP00000447224.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-22	80.1	908	942
UBD/Beta-Prp	5.20e-49	168.7	862	1075

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcla.f.sdtllvsGsdDgtikvWDlrtg 33
           gHt++v+c++ f  +tl  s+s D t+++W+l +g
   Q: 908  GHTGEVRCVKiFaKGTLANSASKDYTLHLWNLLSG 942
           8********9558669***************9776 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.... 131
           ++lsg+ +++ta+ +  ++k+lv g +D++  vwd++    +h l+gh+ +v++++++++g    s+s+d t+++w+l +gq+  +    
   Q: 862  ATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTiwdg 951
           799********************************************************999999******************9999999 PP
   S: 132  .tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
             +++ +  ++ ++v++  +++ s+s  ++++ W+l+t++ + +  g+  d+  ++++  ++  l+++s+dg v lw+  tg+   +++ 
   Q: 952  gSKNPAEPQIWNLHVDEAHKVVYSAS-GSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHM 1040
           98888998999999999776666665.478999*********999999********************************9999888877 PP
   S: 221  ht...dnvksvrfspnderlvsgssDgsiriWdlr 252
            +   +++++    +++  lv+g s gsi++  ++
   Q: 1041 SSikeETPTCAVSVQKQGKLVTGFSNGSISLVSSK 1075
           65666566665555688889999999999876444 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in the control of androgen receptor (AR) protein steady-state levels.

Protein Sequence
(Fasta)

MQRGKPCRAL PTLKCQTFCQ RHGLMFEVVD LRWGIRNIEA TDHLTTELCL EEVDRCWKTS 60
IGPAFVALIG DQYGPCLIPS RIDEKEWEVL RDHLTARPSD LELVARYFQR DENAFPPTYV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGTCTA AATTGGTCGT TCAACTACCA GCAAAGGCTA AAGAGAGGCT GGAGCCCCCA 60
GGACAGCCAG AACGCTGACA CTGCAAAGGG CCTCTGTCCT TACTGGGGAA GCCCAGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0005524--F:ATP binding
GO:0008380--P:RNA splicing

KEGG

hsa:284434

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001525	Ailuropoda melanoleuca	82.46	0.00e+00	2545.00
IUUC-Apl-003467	Anas platyrhynchos	58.80	2.00e-81	295.00
IUUC-Ame-011400	Astyanax mexicanus	36.85	0.00e+00	973.00
IUUC-Bta-013223	Bos taurus	82.18	0.00e+00	2202.00
IUUC-Cel-018404	Caenorhabditis elegans	29.13	2.00e-95	345.00
IUUC-Cja-018773	Callithrix jacchus	89.40	0.00e+00	1695.00
IUUC-Cfa-020334	Canis familiaris	83.28	0.00e+00	2545.00
IUUC-Cpo-022316	Cavia porcellus	65.66	0.00e+00	1930.00
IUUC-Csa-023631	Chlorocebus sabaeus	94.56	0.00e+00	2929.00
IUUC-Cin-025646	Ciona intestinalis	32.14	3.00e-131	463.00
IUUC-Csv-026191	Ciona savignyi	24.68	1.00e-25	110.00
IUUC-Dre-028241	Danio rerio	36.73	0.00e+00	939.00
IUUC-Dno-029990	Dasypus novemcinctus	75.45	0.00e+00	668.00
IUUC-Dor-030869	Dipodomys ordii	62.08	2.00e-174	607.00
IUUC-Ete-033059	Echinops telfairi	83.59	0.00e+00	853.00
IUUC-Eca-033718	Equus caballus	78.39	0.00e+00	2432.00
IUUC-Fca-035748	Felis catus	81.43	0.00e+00	2356.00
IUUC-Gac-041507	Gasterosteus aculeatus	34.55	0.00e+00	732.00
IUUC-Ggo-044551	Gorilla gorilla	94.13	0.00e+00	2913.00
IUUC-Itr-048104	Ictidomys tridecemlineatus	70.45	0.00e+00	1313.00
IUUC-Lch-049578	Latimeria chalumnae	47.13	0.00e+00	1428.00
IUUC-Loc-052039	Lepisosteus oculatus	40.85	0.00e+00	1197.00
IUUC-Laf-054240	Loxodonta africana	81.57	0.00e+00	2583.00
IUUC-Mcc-054657	Macaca mulatta	86.30	0.00e+00	2536.00
IUUC-Meu-056591	Macropus eugenii	62.35	0.00e+00	1147.00
IUUC-Mmr-061577	Microcebus murinus	80.00	0.00e+00	2467.00
IUUC-Mdo-062895	Monodelphis domestica	61.20	0.00e+00	1752.00
IUUC-Mmu-063866	Mus musculus	76.89	0.00e+00	2352.00
IUUC-Mpu-066510	Mustela putorius furo	82.14	0.00e+00	2547.00
IUUC-Mlu-067855	Myotis lucifugus	81.50	0.00e+00	2450.00
IUUC-Nle-069557	Nomascus leucogenys	90.34	0.00e+00	2756.00
IUUC-Opr-071196	Ochotona princeps	63.65	0.00e+00	638.00
IUUC-Ont-072070	Oreochromis niloticus	35.09	0.00e+00	782.00
IUUC-Oan-073437	Ornithorhynchus anatinus	56.79	0.00e+00	1238.00
IUUC-Ocu-074941	Oryctolagus cuniculus	79.09	7.00e-51	193.00
IUUC-Ola-086624	Oryzias latipes	32.92	0.00e+00	687.00
IUUC-Oga-088313	Otolemur garnettii	84.41	0.00e+00	2368.00
IUUC-Oar-090123	Ovis aries	81.11	0.00e+00	2507.00
IUUC-Ptr-090552	Pan troglodytes	98.17	0.00e+00	1301.00
IUUC-Psi-093963	Pelodiscus sinensis	53.36	0.00e+00	1583.00
IUUC-Pfo-096197	Poecilia formosa	34.29	0.00e+00	781.00
IUUC-Pab-097755	Pongo abelii	95.36	0.00e+00	1077.00
IUUC-Pca-100809	Procavia capensis	80.31	0.00e+00	1246.00
IUUC-Pva-102554	Pteropus vampyrus	79.05	0.00e+00	2189.00
IUUC-Rno-105174	Rattus norvegicus	69.98	0.00e+00	2056.00
IUUC-Sha-107304	Sarcophilus harrisii	60.92	0.00e+00	1922.00
IUUC-Sar-113168	Sorex araneus	65.19	0.00e+00	1361.00
IUUC-Tru-118251	Takifugu rubripes	35.52	0.00e+00	671.00
IUUC-Tsy-119276	Tarsius syrichta	76.17	7.00e-117	416.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence