iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000048148.17	ENSMUST00000161557.7	ENSMUSP00000125470.1
ENSMUSG00000048148.17	ENSMUST00000161254.8	ENSMUSP00000124804.1
ENSMUSG00000048148.17	ENSMUST00000093427.10	ENSMUSP00000091135.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-23	81.4	908	942
UBD/Beta-Prp	8.60e-52	177.3	862	1040

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcla.f.sdtllvsGsdDgtikvWDlrtg 33
           gHt++v c++ f ++tl +s+s D+t+++W+l +g
   Q: 908  GHTAEVKCVRvFaQGTLAISASKDHTLRLWSLLSG 942
           8********977988****************9777 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee. 131
           ++l g+ +++ta+ +s ++k+lv g +D++  vwd++  + vh+l gh+++v +++++++g   +s+s+d t+r+w l +gq+  + 
   Q: 862  ATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTi 948
           689999999999999999999999999999999999999999999999999999999999999999999999999999999999998 PP
   S: 132  ....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec 214
                +++++   + ++v++ +n++ s s  r +++W+l+t kl+   tg+  d+  ++++   +  l++ s+ g+v lw+   g+ 
   Q: 949  ldggSQNPTEPQSWDLHVDERNNVVYSTSGAR-INMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKL 1034
           88777777777778888888888777777765.899999999999999999999999999999999999999999999999996655 PP
   S: 215  vrtlng 220
            ++ + 
   Q: 1035 QEKHQL 1040
           333222 PP

Organism

Mus musculus

Functional Description
(View)

May play a role in the control of androgen receptor (AR) protein steady-state levels.

Protein Sequence
(Fasta)

MDTEREALQC TAYPEVQSFC QRHGLAFEVV DLRWGIPNTQ ATDYLTTELC LEELERCQKT 60
SIGPAFVALL GDQYGPCPVP RRIEEKEWEA LRAQLTSRPR DLELVTRHFQ RDDNTIPPTY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTTCCAAA TGACGCCCTC CATGGCAGCA AGAGGGAAGC GGGCATCTTG GAGAGAGCCT 60
GGAGTAGACG CTGCAAAAGG GCCCTTGAAG ATGCCTCATT CTTGCTGAGG TGTTTGCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0005524--F:ATP binding
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001525	Ailuropoda melanoleuca	77.57	0.00e+00	2432.00
IUUC-Apl-003467	Anas platyrhynchos	61.37	1.00e-84	305.00
IUUC-Ame-011400	Astyanax mexicanus	35.61	0.00e+00	952.00
IUUC-Bta-013223	Bos taurus	76.44	0.00e+00	2058.00
IUUC-Cel-018404	Caenorhabditis elegans	28.99	9.00e-98	352.00
IUUC-Cja-018773	Callithrix jacchus	74.49	0.00e+00	1431.00
IUUC-Cfa-020334	Canis familiaris	77.97	0.00e+00	2417.00
IUUC-Cpo-022316	Cavia porcellus	64.71	0.00e+00	1888.00
IUUC-Csa-023631	Chlorocebus sabaeus	77.20	0.00e+00	2378.00
IUUC-Cin-025646	Ciona intestinalis	30.62	3.00e-117	416.00
IUUC-Csv-026191	Ciona savignyi	24.74	5.00e-23	102.00
IUUC-Dre-028241	Danio rerio	35.49	0.00e+00	903.00
IUUC-Dno-029990	Dasypus novemcinctus	76.07	0.00e+00	685.00
IUUC-Dor-030869	Dipodomys ordii	61.04	3.00e-175	609.00
IUUC-Ete-033059	Echinops telfairi	78.89	0.00e+00	801.00
IUUC-Eca-033718	Equus caballus	73.26	0.00e+00	2290.00
IUUC-Fca-035748	Felis catus	77.11	0.00e+00	2219.00
IUUC-Gac-041507	Gasterosteus aculeatus	34.99	0.00e+00	722.00
IUUC-Ggo-044551	Gorilla gorilla	74.82	0.00e+00	2289.00
IUUC-Hsa-046787	Homo sapiens	76.89	0.00e+00	2394.00
IUUC-Itr-048104	Ictidomys tridecemlineatus	61.91	0.00e+00	1748.00
IUUC-Lch-049578	Latimeria chalumnae	46.30	0.00e+00	1358.00
IUUC-Loc-052039	Lepisosteus oculatus	40.94	0.00e+00	1190.00
IUUC-Laf-054240	Loxodonta africana	77.33	0.00e+00	2480.00
IUUC-Mcc-054657	Macaca mulatta	70.25	0.00e+00	2041.00
IUUC-Meu-056591	Macropus eugenii	61.84	0.00e+00	1129.00
IUUC-Mmr-061577	Microcebus murinus	74.69	0.00e+00	2303.00
IUUC-Mdo-062895	Monodelphis domestica	58.43	0.00e+00	1671.00
IUUC-Mpu-066510	Mustela putorius furo	77.19	0.00e+00	2432.00
IUUC-Mlu-067855	Myotis lucifugus	77.19	0.00e+00	2346.00
IUUC-Nle-069557	Nomascus leucogenys	72.79	0.00e+00	2196.00
IUUC-Opr-071196	Ochotona princeps	62.41	7.00e-177	615.00
IUUC-Ont-072070	Oreochromis niloticus	34.91	0.00e+00	763.00
IUUC-Oan-073437	Ornithorhynchus anatinus	55.94	0.00e+00	1199.00
IUUC-Ocu-074941	Oryctolagus cuniculus	80.91	3.00e-51	194.00
IUUC-Ola-086624	Oryzias latipes	34.66	2.00e-127	450.00
IUUC-Oga-088313	Otolemur garnettii	78.21	0.00e+00	2208.00
IUUC-Oar-090123	Ovis aries	76.49	0.00e+00	2383.00
IUUC-Ptr-090552	Pan troglodytes	76.15	0.00e+00	1018.00
IUUC-Psi-093963	Pelodiscus sinensis	52.27	0.00e+00	1533.00
IUUC-Pfo-096197	Poecilia formosa	33.52	0.00e+00	769.00
IUUC-Pab-097755	Pongo abelii	75.31	0.00e+00	851.00
IUUC-Pca-100809	Procavia capensis	73.90	0.00e+00	1148.00
IUUC-Pva-102554	Pteropus vampyrus	74.30	0.00e+00	2050.00
IUUC-Rno-105174	Rattus norvegicus	84.78	0.00e+00	2476.00
IUUC-Sha-107304	Sarcophilus harrisii	58.89	0.00e+00	1878.00
IUUC-Sar-113168	Sorex araneus	63.02	0.00e+00	1312.00
IUUC-Tru-118251	Takifugu rubripes	36.08	0.00e+00	663.00
IUUC-Tsy-119276	Tarsius syrichta	73.48	7.00e-114	405.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence