iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005014

Ensembl Protein ID

ENSACAP00000014121.2

UniProt Accession

H9GL05; H9GL05_ANOCA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000014413.2	ENSACAT00000014411.2	ENSACAP00000014121.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	2.00e-125	445.00	IUUC-Dme-031700
E3 activity/RING/RING	99.65	3.00e-169	591.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.29	3.00e-168	587.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Anolis carolinensis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

YILKKKILPK HYFLAEMSRQ TATALPTGTS KCTPSQRVPA LTGTTASNND LASLFECPVC 60
FDYVLPPILQ CQSGHLVCSN CRPKLTCCPT CRGPLGSIRN LAMEKVANSV LFPCKYASSG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATATCTTAA AAAAAAAGAT TCTACCTAAA CATTAGGAAG AACTTTCTGA TGGTAAGGGC 60
TGTTCATCAG TGGAATATGT TGTCTCGTAG TTTGGTGGAG TGTCCTTCTG TGAAAGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.36	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	100.00	2.00e-171	594.00
IUUC-Atr-002857	Amborella trichopoda	36.06	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	100.00	1.00e-170	591.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	1.00e-41	162.00
IUUC-Ath-007049	Arabidopsis thaliana	33.45	8.00e-42	163.00
IUUC-Ame-011196	Astyanax mexicanus	94.24	5.00e-169	586.00
IUUC-Bta-012887	Bos taurus	99.65	8.00e-171	592.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	4.00e-45	174.00
IUUC-Bol-015523	Brassica oleracea	36.36	6.00e-42	164.00
IUUC-Bra-016910	Brassica rapa	36.82	3.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	67.15	2.00e-114	405.00
IUUC-Cja-019796	Callithrix jacchus	99.65	2.00e-170	591.00
IUUC-Cfa-020642	Canis familiaris	100.00	2.00e-172	597.00
IUUC-Cpo-022348	Cavia porcellus	99.65	5.00e-170	589.00
IUUC-Csa-023974	Chlorocebus sabaeus	99.65	1.00e-170	591.00
IUUC-Cho-024933	Choloepus hoffmanni	84.92	1.00e-130	458.00
IUUC-Cin-025674	Ciona intestinalis	78.01	5.00e-135	473.00
IUUC-Csv-026233	Ciona savignyi	84.25	3.00e-132	463.00
IUUC-Dre-028041	Danio rerio	94.24	6.00e-169	586.00
IUUC-Dno-029764	Dasypus novemcinctus	100.00	2.00e-171	594.00
IUUC-Dor-030489	Dipodomys ordii	84.70	1.00e-94	338.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	5.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	99.63	1.00e-160	558.00
IUUC-Eca-033536	Equus caballus	100.00	1.00e-170	591.00
IUUC-Eeu-035314	Erinaceus europaeus	99.25	5.00e-161	560.00
IUUC-Fca-035362	Felis catus	100.00	1.00e-171	594.00
IUUC-Fal-037487	Ficedula albicollis	100.00	2.00e-171	593.00
IUUC-Gmo-039091	Gadus morhua	80.45	8.00e-129	452.00
IUUC-Gga-040269	Gallus gallus	100.00	1.00e-170	591.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.16	6.00e-167	579.00
IUUC-Gma-042926	Glycine max	34.44	1.00e-40	159.00
IUUC-Ggo-045444	Gorilla gorilla	99.65	1.00e-170	591.00
IUUC-Hsa-046357	Homo sapiens	99.65	1.00e-170	591.00
IUUC-Hvu-047574	Hordeum vulgare	37.00	3.00e-44	172.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	99.65	5.00e-170	589.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	3.00e-169	586.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	166.00
IUUC-Loc-052191	Lepisosteus oculatus	96.61	2.00e-171	594.00
IUUC-Laf-053668	Loxodonta africana	100.00	1.00e-170	591.00
IUUC-Mcc-054640	Macaca mulatta	99.65	1.00e-170	591.00
IUUC-Meu-055922	Macropus eugenii	83.33	1.00e-127	448.00
IUUC-Mtr-058747	Medicago truncatula	34.81	3.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	97.28	2.00e-172	597.00
IUUC-Mmr-060794	Microcebus murinus	99.65	5.00e-170	589.00
IUUC-Mdo-061971	Monodelphis domestica	84.92	2.00e-130	457.00
IUUC-Mmu-064129	Mus musculus	99.29	2.00e-169	587.00
IUUC-Mac-065014	Musa acuminata	36.64	6.00e-42	164.00
IUUC-Mpu-066488	Mustela putorius furo	100.00	2.00e-171	593.00
IUUC-Mlu-067207	Myotis lucifugus	99.30	5.00e-172	596.00
IUUC-Nle-069706	Nomascus leucogenys	99.65	1.00e-170	591.00
IUUC-Opr-070341	Ochotona princeps	55.56	3.00e-49	187.00
IUUC-Ont-071849	Oreochromis niloticus	96.50	2.00e-168	584.00
IUUC-Oan-073701	Ornithorhynchus anatinus	52.56	5.00e-49	187.00
IUUC-Ocu-074876	Oryctolagus cuniculus	99.65	2.00e-170	590.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Obr-076037	Oryza brachyantha	35.43	3.00e-40	158.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.83	2.00e-42	166.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	6.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.16	6.00e-167	579.00
IUUC-Oga-088399	Otolemur garnettii	99.65	5.00e-170	589.00
IUUC-Oar-089323	Ovis aries	99.65	1.00e-170	592.00
IUUC-Ptr-090692	Pan troglodytes	97.60	2.00e-173	600.00
IUUC-Pan-092012	Papio anubis	99.65	1.00e-170	591.00
IUUC-Psi-093687	Pelodiscus sinensis	100.00	9.00e-172	595.00
IUUC-Pma-094387	Petromyzon marinus	93.73	3.00e-162	563.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	6.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	97.16	6.00e-167	579.00
IUUC-Pab-097555	Pongo abelii	99.65	1.00e-170	591.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	171.00
IUUC-Pca-100328	Procavia capensis	83.33	9.00e-127	446.00
IUUC-Ppe-101760	Prunus persica	36.10	4.00e-44	171.00
IUUC-Pva-102368	Pteropus vampyrus	90.00	7.00e-57	213.00
IUUC-Rno-104866	Rattus norvegicus	99.29	2.00e-169	587.00
IUUC-Sha-106547	Sarcophilus harrisii	100.00	1.00e-171	594.00
IUUC-Smo-109412	Selaginella moellendorffii	33.68	3.00e-39	155.00
IUUC-Sit-110595	Setaria italica	37.45	2.00e-41	162.00
IUUC-Sly-111259	Solanum lycopersicum	36.76	2.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	36.76	2.00e-41	162.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	3.00e-42	165.00
IUUC-Ssc-116441	Sus scrofa	84.52	3.00e-130	457.00
IUUC-Tgu-116579	Taeniopygia guttata	100.00	1.00e-170	591.00
IUUC-Tru-118250	Takifugu rubripes	92.91	6.00e-159	552.00
IUUC-Tsy-119548	Tarsius syrichta	81.68	8.00e-60	223.00
IUUC-Tni-120488	Tetraodon nigroviridis	96.81	2.00e-163	567.00
IUUC-Tca-121228	Theobroma cacao	33.33	3.00e-41	162.00
IUUC-Tae-123647	Triticum aestivum	37.36	2.00e-44	172.00
IUUC-Tur-126049	Triticum urartu	35.04	7.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	2.00e-143	501.00
IUUC-Vpa-130799	Vicugna pacos	88.30	1.00e-91	328.00
IUUC-Vvi-131233	Vitis vinifera	34.15	6.00e-43	167.00
IUUC-Xtr-132553	Xenopus tropicalis	98.94	1.00e-169	588.00
IUUC-Xma-133670	Xiphophorus maculatus	97.16	6.00e-167	579.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence