iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025674

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

EAAA01000694

Gene Name

LOC100176189

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000024656.1	ENSCINT00000033263.1	ENSCINP00000034692.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	34.88	1.00e-37	153.00	IUUC-Ath-007192
E3 activity/RING/RING	80.63	2.00e-123	438.00	IUUC-Dme-031700
E3 activity/RING/RING	78.01	2.00e-133	472.00	IUUC-Hsa-046357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ciona intestinalis

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSRQSSNIVS VAGNERQVEG MAAGLACASG NELDLASLFE CPVCFDYVLP PILQCQSGHL 60
VCTNCRPKLT CCPTCRGALG NIRNLGMEKV AMTVDFPCKY AASGCEVTLR YIQKPEHEET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCAACGTT AGGATGTAAA AAATAACGTT GCAAATGTAA AATGGACTTA AACTGTTCCT 60
GAGTCATTAA ATCAAAAACA TGAGCAGGCA ATCGTCAAAC ATTGTGAGTG TTGCTGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cin:100176189

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	35.98	5.00e-42	163.00
IUUC-Aml-001186	Ailuropoda melanoleuca	78.01	4.00e-135	472.00
IUUC-Atr-002857	Amborella trichopoda	37.70	1.00e-45	174.00
IUUC-Apl-003813	Anas platyrhynchos	78.01	3.00e-135	472.00
IUUC-Aca-005014	Anolis carolinensis	78.01	2.00e-135	473.00
IUUC-Aly-006522	Arabidopsis lyrata	35.27	2.00e-39	154.00
IUUC-Ath-007192	Arabidopsis thaliana	34.88	5.00e-39	153.00
IUUC-Ame-011196	Astyanax mexicanus	78.37	2.00e-135	473.00
IUUC-Bta-012887	Bos taurus	78.01	4.00e-135	472.00
IUUC-Bdi-014200	Brachypodium distachyon	35.98	7.00e-43	166.00
IUUC-Bol-016263	Brassica oleracea	34.15	8.00e-40	155.00
IUUC-Bra-017336	Brassica rapa	34.94	6.00e-41	159.00
IUUC-Cel-018320	Caenorhabditis elegans	66.28	1.00e-107	382.00
IUUC-Cja-019796	Callithrix jacchus	78.01	4.00e-135	472.00
IUUC-Cfa-020642	Canis familiaris	78.01	8.00e-136	474.00
IUUC-Cpo-022348	Cavia porcellus	78.01	6.00e-135	471.00
IUUC-Csa-023974	Chlorocebus sabaeus	78.01	4.00e-135	472.00
IUUC-Cho-024933	Choloepus hoffmanni	83.60	5.00e-128	448.00
IUUC-Csv-026233	Ciona savignyi	98.03	2.00e-152	530.00
IUUC-Dre-028041	Danio rerio	78.37	2.00e-135	473.00
IUUC-Dno-029764	Dasypus novemcinctus	78.01	3.00e-135	473.00
IUUC-Dor-030489	Dipodomys ordii	83.06	7.00e-95	337.00
IUUC-Dme-031700	Drosophila melanogaster	81.85	3.00e-118	416.00
IUUC-Ete-032946	Echinops telfairi	84.00	2.00e-128	449.00
IUUC-Eca-033536	Equus caballus	78.01	3.00e-135	472.00
IUUC-Eeu-035314	Erinaceus europaeus	77.44	1.00e-125	441.00
IUUC-Fca-035362	Felis catus	78.01	3.00e-135	473.00
IUUC-Fal-037487	Ficedula albicollis	78.01	4.00e-135	472.00
IUUC-Gmo-039091	Gadus morhua	78.35	2.00e-124	437.00
IUUC-Gga-040269	Gallus gallus	78.01	3.00e-135	472.00
IUUC-Gac-042282	Gasterosteus aculeatus	78.72	2.00e-135	473.00
IUUC-Gma-042926	Glycine max	32.50	2.00e-41	161.00
IUUC-Ggo-045444	Gorilla gorilla	78.01	4.00e-135	472.00
IUUC-Hsa-046357	Homo sapiens	78.01	4.00e-135	472.00
IUUC-Hvu-047574	Hordeum vulgare	35.98	3.00e-42	163.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	78.01	6.00e-135	471.00
IUUC-Lch-049504	Latimeria chalumnae	78.01	3.00e-135	472.00
IUUC-Lpe-050879	Leersia perrieri	36.14	1.00e-40	159.00
IUUC-Loc-052191	Lepisosteus oculatus	78.37	2.00e-135	473.00
IUUC-Laf-053668	Loxodonta africana	78.01	3.00e-135	472.00
IUUC-Mcc-054640	Macaca mulatta	78.01	4.00e-135	472.00
IUUC-Meu-055922	Macropus eugenii	82.00	6.00e-125	438.00
IUUC-Mtr-058747	Medicago truncatula	33.93	1.00e-43	168.00
IUUC-Mga-059503	Meleagris gallopavo	78.01	3.00e-135	473.00
IUUC-Mvi-060329	Microbotryum violaceum	37.50	2.10e-01	29.60
IUUC-Mmr-060794	Microcebus murinus	78.01	6.00e-135	471.00
IUUC-Mdo-061971	Monodelphis domestica	82.40	1.00e-126	444.00
IUUC-Mmu-063876	Mus musculus	78.72	6.00e-136	475.00
IUUC-Mac-065014	Musa acuminata	36.59	4.00e-41	160.00
IUUC-Mpu-066488	Mustela putorius furo	78.01	4.00e-135	472.00
IUUC-Mlu-067207	Myotis lucifugus	78.01	2.00e-135	473.00
IUUC-Nle-069706	Nomascus leucogenys	78.01	4.00e-135	472.00
IUUC-Opr-070341	Ochotona princeps	54.90	6.00e-49	186.00
IUUC-Ont-071849	Oreochromis niloticus	78.72	1.00e-135	473.00
IUUC-Oan-073701	Ornithorhynchus anatinus	53.85	5.00e-49	186.00
IUUC-Ocu-074876	Oryctolagus cuniculus	78.01	6.00e-135	471.00
IUUC-Oba-075789	Oryza barthii	35.66	6.00e-43	166.00
IUUC-Obr-076037	Oryza brachyantha	35.55	1.00e-42	165.00
IUUC-Ogl-077148	Oryza glaberrima	35.66	6.00e-43	166.00
IUUC-Ogu-078042	Oryza glumaepatula	35.66	5.00e-43	166.00
IUUC-Oin-079325	Oryza indica	35.66	5.00e-43	166.00
IUUC-Olo-080244	Oryza longistaminata	35.66	9.00e-43	166.00
IUUC-Ome-081318	Oryza meridionalis	36.00	6.00e-41	159.00
IUUC-Oni-082163	Oryza nivara	35.66	6.00e-43	166.00
IUUC-Opu-084065	Oryza punctata	36.40	3.00e-41	160.00
IUUC-Oru-084833	Oryza rufipogon	35.66	5.00e-43	166.00
IUUC-Osa-085316	Oryza sativa	35.66	5.00e-43	166.00
IUUC-Ola-086814	Oryzias latipes	78.72	2.00e-135	473.00
IUUC-Oga-088399	Otolemur garnettii	78.01	6.00e-135	471.00
IUUC-Oar-089323	Ovis aries	78.01	4.00e-135	472.00
IUUC-Ptr-090692	Pan troglodytes	78.01	3.00e-135	472.00
IUUC-Pan-092012	Papio anubis	78.01	4.00e-135	472.00
IUUC-Psi-093687	Pelodiscus sinensis	78.01	2.00e-135	473.00
IUUC-Pma-094387	Petromyzon marinus	76.68	4.00e-132	462.00
IUUC-Ppa-095212	Physcomitrella patens	35.37	3.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	78.72	2.00e-135	473.00
IUUC-Pab-097555	Pongo abelii	78.01	4.00e-135	472.00
IUUC-Pop-099563	Populus trichocarpa	35.20	7.00e-45	172.00
IUUC-Pca-100328	Procavia capensis	83.20	4.00e-125	439.00
IUUC-Ppe-101760	Prunus persica	33.56	9.00e-43	165.00
IUUC-Pva-102368	Pteropus vampyrus	89.09	3.00e-57	213.00
IUUC-Rno-104866	Rattus norvegicus	78.37	2.00e-135	473.00
IUUC-Sha-106547	Sarcophilus harrisii	78.01	2.00e-135	473.00
IUUC-Smo-109412	Selaginella moellendorffii	34.15	2.00e-39	154.00
IUUC-Sit-110245	Setaria italica	35.20	8.00e-42	162.00
IUUC-Sly-111117	Solanum lycopersicum	32.02	2.00e-40	158.00
IUUC-Stu-112474	Solanum tuberosum	34.94	9.00e-42	162.00
IUUC-Sbi-114035	Sorghum bicolor	35.20	4.00e-42	163.00
IUUC-Ssc-116441	Sus scrofa	84.00	3.00e-128	449.00
IUUC-Tgu-116579	Taeniopygia guttata	78.01	3.00e-135	472.00
IUUC-Tru-118250	Takifugu rubripes	84.11	1.00e-132	463.00
IUUC-Tsy-119548	Tarsius syrichta	81.82	1.00e-61	227.00
IUUC-Tni-120488	Tetraodon nigroviridis	78.01	1.00e-131	460.00
IUUC-Tca-121228	Theobroma cacao	35.74	8.00e-43	166.00
IUUC-Tae-123647	Triticum aestivum	35.98	5.00e-42	163.00
IUUC-Tur-126049	Triticum urartu	34.40	2.00e-40	157.00
IUUC-Ttr-129166	Tursiops truncatus	84.94	9.00e-122	428.00
IUUC-Vpa-130799	Vicugna pacos	88.82	5.00e-92	328.00
IUUC-Vvi-131451	Vitis vinifera	33.71	2.00e-41	161.00
IUUC-Xtr-132553	Xenopus tropicalis	78.37	2.00e-135	473.00
IUUC-Xma-133670	Xiphophorus maculatus	78.72	2.00e-135	473.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence