iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058747

Ensembl Protein ID

AET02270

UniProt Accession

G7LFA2; G7LFA2_MEDTR

Genbank Protein ID

AET02270.2

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

CM001224

Gene Name

MTR_8g038370

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_8g038370	AET02270	AET02270

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	34.81	1.00e-40	165.00	IUUC-Hsa-046357
E3 activity/RING/RING	35.19	3.00e-41	166.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Medicago truncatula

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MDDDEIFPSV CHLSWSGDVI PDYLCYINSI TKVNKNNSID FNSNVFSPLT GPLGISLASM 60
ALSNPLFDDI RSNIDVDPPQ KEESTDVGIL VNDPAQTALK PTGTVLSSVR ELLECPVCLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACG ATGAAATATT TCCCAGTGTT TGTCATTTAA GCTGGTCAGG GGATGTAATA 60
CCTGACTACT TATGCTATAT TAACAGTATA ACGAAAGTAA ACAAGAATAA CTCTATTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mtr:MTR_8g038370

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001186	Ailuropoda melanoleuca	34.81	2.00e-42	165.00
IUUC-Apl-003813	Anas platyrhynchos	34.81	2.00e-42	165.00
IUUC-Aca-005014	Anolis carolinensis	34.81	2.00e-42	165.00
IUUC-Ame-011196	Astyanax mexicanus	34.81	2.00e-42	165.00
IUUC-Bta-012887	Bos taurus	34.81	2.00e-42	165.00
IUUC-Cel-018320	Caenorhabditis elegans	32.55	3.00e-37	149.00
IUUC-Cja-019796	Callithrix jacchus	34.81	2.00e-42	165.00
IUUC-Cfa-020642	Canis familiaris	34.81	2.00e-42	165.00
IUUC-Cpo-022348	Cavia porcellus	34.81	2.00e-42	165.00
IUUC-Csa-023974	Chlorocebus sabaeus	34.81	2.00e-42	165.00
IUUC-Cho-024933	Choloepus hoffmanni	34.92	7.00e-38	150.00
IUUC-Cin-025674	Ciona intestinalis	33.93	2.00e-43	168.00
IUUC-Csv-026233	Ciona savignyi	36.55	1.00e-43	169.00
IUUC-Dre-028041	Danio rerio	33.92	2.00e-42	166.00
IUUC-Dno-029764	Dasypus novemcinctus	34.81	2.00e-42	165.00
IUUC-Dor-030489	Dipodomys ordii	29.73	2.00e-18	85.10
IUUC-Ete-032423	Echinops telfairi	35.07	6.00e-42	164.00
IUUC-Eca-033536	Equus caballus	34.81	2.00e-42	165.00
IUUC-Eeu-035314	Erinaceus europaeus	35.07	6.00e-42	164.00
IUUC-Fca-035362	Felis catus	34.81	2.00e-42	165.00
IUUC-Fal-037487	Ficedula albicollis	34.81	2.00e-42	165.00
IUUC-Gmo-039091	Gadus morhua	34.25	2.00e-36	145.00
IUUC-Gga-040269	Gallus gallus	34.81	2.00e-42	165.00
IUUC-Gac-042282	Gasterosteus aculeatus	34.81	1.00e-42	165.00
IUUC-Ggo-045444	Gorilla gorilla	34.81	2.00e-42	165.00
IUUC-Hsa-046357	Homo sapiens	34.81	2.00e-42	165.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	34.81	2.00e-42	165.00
IUUC-Lch-049504	Latimeria chalumnae	34.81	2.00e-42	165.00
IUUC-Loc-052191	Lepisosteus oculatus	35.19	1.00e-42	166.00
IUUC-Laf-053668	Loxodonta africana	34.81	2.00e-42	165.00
IUUC-Mcc-054640	Macaca mulatta	34.81	2.00e-42	165.00
IUUC-Meu-055922	Macropus eugenii	34.92	4.00e-37	147.00
IUUC-Mga-059503	Meleagris gallopavo	34.81	2.00e-42	165.00
IUUC-Mmr-060794	Microcebus murinus	34.81	2.00e-42	165.00
IUUC-Mdo-061971	Monodelphis domestica	34.52	2.00e-37	148.00
IUUC-Mmu-064129	Mus musculus	35.19	7.00e-43	166.00
IUUC-Mpu-066488	Mustela putorius furo	34.81	2.00e-42	165.00
IUUC-Mlu-067207	Myotis lucifugus	34.81	1.00e-42	165.00
IUUC-Nle-069706	Nomascus leucogenys	34.81	2.00e-42	165.00
IUUC-Ont-071849	Oreochromis niloticus	34.81	1.00e-42	166.00
IUUC-Ocu-074876	Oryctolagus cuniculus	34.81	2.00e-42	165.00
IUUC-Ola-086814	Oryzias latipes	34.81	1.00e-42	165.00
IUUC-Oga-088399	Otolemur garnettii	34.81	2.00e-42	165.00
IUUC-Oar-089323	Ovis aries	34.81	2.00e-42	165.00
IUUC-Ptr-090692	Pan troglodytes	34.81	2.00e-42	165.00
IUUC-Pan-092012	Papio anubis	34.81	2.00e-42	165.00
IUUC-Psi-093687	Pelodiscus sinensis	34.81	2.00e-42	165.00
IUUC-Pma-094387	Petromyzon marinus	36.12	1.00e-43	169.00
IUUC-Pfo-097134	Poecilia formosa	34.81	1.00e-42	165.00
IUUC-Pab-097555	Pongo abelii	34.81	2.00e-42	165.00
IUUC-Pca-100328	Procavia capensis	34.52	3.00e-35	141.00
IUUC-Rno-104866	Rattus norvegicus	35.19	7.00e-43	166.00
IUUC-Sha-106547	Sarcophilus harrisii	34.81	2.00e-42	165.00
IUUC-Ssc-116441	Sus scrofa	35.32	4.00e-38	150.00
IUUC-Tgu-116579	Taeniopygia guttata	34.81	2.00e-42	165.00
IUUC-Tni-120488	Tetraodon nigroviridis	34.80	3.00e-40	157.00
IUUC-Ttr-129166	Tursiops truncatus	36.18	1.00e-39	156.00
IUUC-Vpa-130799	Vicugna pacos	30.99	4.00e-19	86.70
IUUC-Xtr-132553	Xenopus tropicalis	34.81	2.00e-42	165.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence