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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045795
Ensembl Protein ID ENSP00000403817.1
UniProt Accession E9PAV3; NACAM_HUMAN
Genbank Protein ID ENSP00000403817
Protein Name Nascent polypeptide-associated complex subunit alpha, muscle-specific form; Alpha-NAC, muscle-specific form
Genbank Nucleotide ID AK096699
Gene Name NACA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196531.10 ENST00000550920.5 ENSP00000448039.1
ENSG00000196531.10 ENST00000550952.5 ENSP00000448035.1
ENSG00000196531.10 ENST00000356769.7 ENSP00000349212.3
ENSG00000196531.10 ENST00000547914.5 ENSP00000446745.1
ENSG00000196531.10 ENST00000552055.5 ENSP00000450383.1
ENSG00000196531.10 ENST00000548084.1 ENSP00000447207.1
ENSG00000196531.10 ENST00000454682.5 ENSP00000403817.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
HPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 47.33 2.00e-24 110.00 IUUC-Spo-108121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).
 Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres (By similarity).
Protein Sequence
(Fasta)
MPGEATETVP ATEQELPQPQ AETAVLPMSS ALSVTAALGQ PGPTLPPPCS PAPQQCPLSA 60
ANQASPFPSP STIASTPLEV PFPQSSSGTA LPLGTAPEAP TFLPNLIGPP ISPAALALAS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045795|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACTATATAT GTGTCTTAAA CCTCAAAGTA AATTTTCCTT GAGAAATAAT TTATGTTGAA 60
AAGATTTCCT GGCCAAGTGC AGTGGCTCAC ACCCGTAATC CCAGCACTTT GGGAGGCCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045795|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom
PROSITE

PS51151--NAC_AB
Pfam

PF01849--NAC
SMART

SM01407--NAC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001167 Aegilops tauschii 59.03 3.00e-35 141.00
IUUC-Aml-001719 Ailuropoda melanoleuca 60.50 0.00e+00 695.00
IUUC-Atr-002586 Amborella trichopoda 50.00 1.00e-26 113.00
IUUC-Apl-003190 Anas platyrhynchos 73.25 2.00e-47 181.00
IUUC-Aca-005265 Anolis carolinensis 97.40 1.00e-88 318.00
IUUC-Aly-006397 Arabidopsis lyrata 62.50 2.00e-36 144.00
IUUC-Ath-007378 Arabidopsis thaliana 59.42 2.00e-29 121.00
IUUC-Ago-007936 Ashbya gossypii 40.65 9.00e-21 92.80
IUUC-Acl-008036 Aspergillus clavatus 70.49 6.00e-23 100.00
IUUC-Afl-008462 Aspergillus flavus 70.31 5.00e-25 107.00
IUUC-Afu-008832 Aspergillus fumigatus 51.25 1.00e-26 112.00
IUUC-Ani-009246 Aspergillus nidulans 70.31 1.00e-24 106.00
IUUC-Ang-009808 Aspergillus niger 70.49 4.00e-23 100.00
IUUC-Aor-009972 Aspergillus oryzae 70.31 5.00e-25 107.00
IUUC-Ame-011674 Astyanax mexicanus 88.94 7.00e-79 286.00
IUUC-Bgr-012162 Blumeria graminis 70.59 2.00e-25 108.00
IUUC-Bta-012508 Bos taurus 100.00 1.00e-87 315.00
IUUC-Bci-013643 Botrytis cinerea 73.02 6.00e-24 103.00
IUUC-Bdi-014874 Brachypodium distachyon 58.70 2.00e-32 132.00
IUUC-Bol-015681 Brassica oleracea 58.82 1.00e-34 139.00
IUUC-Bra-017540 Brassica rapa 59.42 2.00e-34 138.00
IUUC-Cel-018111 Caenorhabditis elegans 66.01 2.00e-49 188.00
IUUC-Cja-019846 Callithrix jacchus 62.25 4.00e-59 224.00
IUUC-Cfa-020429 Canis familiaris 93.78 1.00e-88 318.00
IUUC-Cpo-022542 Cavia porcellus 99.47 4.00e-76 277.00
IUUC-Cre-022679 Chlamydomonas reinhardtii 66.00 2.00e-49 187.00
IUUC-Csa-023260 Chlorocebus sabaeus 66.33 1.00e-60 229.00
IUUC-Cho-024869 Choloepus hoffmanni 100.00 7.00e-33 133.00
IUUC-Cin-025166 Ciona intestinalis 71.33 3.00e-54 204.00
IUUC-Csv-026284 Ciona savignyi 68.28 7.00e-45 172.00
IUUC-Cgl-026520 Colletotrichum gloeosporioides 71.88 3.00e-24 105.00
IUUC-Cne-026920 Cryptococcus neoformans 61.29 3.00e-21 94.70
IUUC-Cme-027301 Cyanidioschyzon merolae 49.41 1.00e-27 116.00
IUUC-Dre-028709 Danio rerio 92.31 2.00e-86 314.00
IUUC-Dno-029786 Dasypus novemcinctus 56.48 2.00e-166 580.00
IUUC-Dor-030962 Dipodomys ordii 93.75 5.00e-83 300.00
IUUC-Dme-032061 Drosophila melanogaster 81.58 3.00e-34 138.00
IUUC-Ete-032965 Echinops telfairi 92.71 2.00e-82 297.00
IUUC-Eca-034049 Equus caballus 99.48 9.00e-87 312.00
IUUC-Eeu-034673 Erinaceus europaeus 100.00 9.00e-88 315.00
IUUC-Fca-036369 Felis catus 61.82 0.00e+00 693.00
IUUC-Fal-037006 Ficedula albicollis 98.98 9.00e-89 319.00
IUUC-Fox-037704 Fusarium oxysporum 52.41 2.00e-27 115.00
IUUC-Fso-038247 Fusarium solani 67.19 8.00e-23 100.00
IUUC-Gmo-039002 Gadus morhua 69.23 8.00e-48 183.00
IUUC-Ggr-039888 Gaeumannomyces graminis 51.88 6.00e-29 120.00
IUUC-Gga-040237 Gallus gallus 99.48 5.00e-87 313.00
IUUC-Gac-041800 Gasterosteus aculeatus 96.88 2.00e-72 266.00
IUUC-Gma-043275 Glycine max 61.59 9.00e-43 166.00
IUUC-Ggo-045163 Gorilla gorilla 67.36 1.00e-61 229.00
IUUC-Hvu-047376 Hordeum vulgare 58.33 2.00e-34 139.00
IUUC-Itr-048152 Ictidomys tridecemlineatus 100.00 9.00e-88 315.00
IUUC-Kpa-049166 Komagataella pastoris 38.79 8.00e-23 100.00
IUUC-Lch-050076 Latimeria chalumnae 89.86 1.00e-87 315.00
IUUC-Lpe-051016 Leersia perrieri 56.85 3.00e-39 154.00
IUUC-Loc-052292 Lepisosteus oculatus 97.87 2.00e-74 272.00
IUUC-Lma-053293 Leptosphaeria maculans 49.70 7.00e-31 126.00
IUUC-Laf-054393 Loxodonta africana 63.86 2.00e-60 225.00
IUUC-Mcc-054632 Macaca mulatta 87.27 0.00e+00 1031.00
IUUC-Meu-056242 Macropus eugenii 100.00 8.00e-73 266.00
IUUC-Mor-057099 Magnaporthe oryzae 54.19 9.00e-28 116.00
IUUC-Mpo-057543 Magnaporthe poae 67.24 1.00e-17 82.80
IUUC-Mtr-058769 Medicago truncatula 59.42 7.00e-28 117.00
IUUC-Mla-059166 Melampsora laricipopulina 41.03 2.00e-24 105.00
IUUC-Mga-059406 Meleagris gallopavo 99.48 3.00e-87 314.00
IUUC-Mvi-060390 Microbotryum violaceum 39.62 2.00e-22 98.20
IUUC-Mmr-061569 Microcebus murinus 100.00 2.00e-87 315.00
IUUC-Mdo-062474 Monodelphis domestica 69.54 2.00e-62 235.00
IUUC-Mmu-063984 Mus musculus 74.94 2.00e-113 405.00
IUUC-Mac-065175 Musa acuminata 56.25 2.00e-37 148.00
IUUC-Mpu-065793 Mustela putorius furo 57.75 0.00e+00 680.00
IUUC-Mlu-068234 Myotis lucifugus 100.00 9.00e-88 315.00
IUUC-Nfi-068541 Neosartorya fischeri 51.25 1.00e-26 112.00
IUUC-Ncr-068830 Neurospora crassa 56.21 3.00e-28 118.00
IUUC-Nle-069126 Nomascus leucogenys 100.00 4.00e-87 314.00
IUUC-Opr-070742 Ochotona princeps 100.00 2.00e-77 281.00
IUUC-Ont-071828 Oreochromis niloticus 94.90 1.00e-76 279.00
IUUC-Oan-073462 Ornithorhynchus anatinus 97.92 4.00e-83 303.00
IUUC-Ocu-074890 Oryctolagus cuniculus 63.32 4.00e-60 227.00
IUUC-Oba-075995 Oryza barthii 59.72 5.00e-40 157.00
IUUC-Obr-076073 Oryza brachyantha 58.33 4.00e-40 157.00
IUUC-Ogl-077445 Oryza glaberrima 59.72 5.00e-40 157.00
IUUC-Ogu-078606 Oryza glumaepatula 59.72 5.00e-40 157.00
IUUC-Oin-079287 Oryza indica 59.72 5.00e-40 157.00
IUUC-Olo-080686 Oryza longistaminata 49.70 7.00e-35 140.00
IUUC-Ome-081567 Oryza meridionalis 56.16 6.00e-39 153.00
IUUC-Oni-082873 Oryza nivara 59.72 5.00e-40 157.00
IUUC-Opu-083488 Oryza punctata 58.70 3.00e-36 144.00
IUUC-Oru-084592 Oryza rufipogon 59.72 5.00e-40 157.00
IUUC-Osa-086102 Oryza sativa 59.72 5.00e-40 157.00
IUUC-Ola-087531 Oryzias latipes 98.69 8.00e-77 279.00
IUUC-Olu-087895 Ostreococcus lucimarinus 53.28 3.00e-31 126.00
IUUC-Oga-088239 Otolemur garnettii 100.00 9.00e-88 315.00
IUUC-Oar-089723 Ovis aries 67.11 3.00e-149 523.00
IUUC-Ptr-090481 Pan troglodytes 67.68 1.00e-58 222.00
IUUC-Pan-092223 Papio anubis 92.01 0.00e+00 684.00
IUUC-Psi-093588 Pelodiscus sinensis 98.96 9.00e-88 315.00
IUUC-Pma-094702 Petromyzon marinus 85.62 6.00e-63 233.00
IUUC-Pno-094927 Phaeosphaeria nodorum 48.52 2.00e-29 122.00
IUUC-Ppa-095389 Physcomitrella patens 67.11 2.00e-38 152.00
IUUC-Pfo-096744 Poecilia formosa 96.73 5.00e-71 260.00
IUUC-Pab-098044 Pongo abelii 100.00 9.00e-88 315.00
IUUC-Pop-099938 Populus trichocarpa 62.50 9.00e-38 149.00
IUUC-Pca-100355 Procavia capensis 67.84 1.00e-58 221.00
IUUC-Ppe-101786 Prunus persica 62.50 4.00e-38 150.00
IUUC-Pva-102494 Pteropus vampyrus 97.92 7.00e-86 309.00
IUUC-Pgr-103303 Puccinia graminis 40.88 6.00e-23 100.00
IUUC-Ptt-103748 Puccinia triticina 59.52 1.00e-10 60.10
IUUC-Pte-104368 Pyrenophora teres 69.12 3.00e-26 111.00
IUUC-Pyt-104542 Pyrenophora triticirepentis 69.12 3.00e-26 111.00
IUUC-Rno-105387 Rattus norvegicus 77.85 5.00e-139 490.00
IUUC-Sce-106371 Saccharomyces cerevisiae 38.89 9.00e-20 89.70
IUUC-Sha-107189 Sarcophilus harrisii 100.00 9.00e-88 315.00
IUUC-Sja-107942 Schizosaccharomyces japonicus 45.40 2.00e-23 102.00
IUUC-Spo-108121 Schizosaccharomyces pombe 46.54 2.00e-28 118.00
IUUC-Ssl-108595 Sclerotinia sclerotiorum 71.88 6.00e-24 103.00
IUUC-Smo-108783 Selaginella moellendorffii 66.18 7.00e-38 150.00
IUUC-Sit-109728 Setaria italica 63.77 1.00e-37 149.00
IUUC-Sly-110957 Solanum lycopersicum 63.24 2.00e-32 132.00
IUUC-Stu-112873 Solanum tuberosum 63.24 3.00e-33 134.00
IUUC-Sar-113668 Sorex araneus 100.00 3.00e-32 131.00
IUUC-Sbi-114223 Sorghum bicolor 57.64 1.00e-35 142.00
IUUC-Sre-115220 Sporisorium reilianum 44.00 2.00e-24 105.00
IUUC-Ssc-116119 Sus scrofa 100.00 9.00e-88 315.00
IUUC-Tgu-116528 Taeniopygia guttata 99.47 5.00e-84 303.00
IUUC-Tru-117538 Takifugu rubripes 96.35 1.00e-77 282.00
IUUC-Tsy-118855 Tarsius syrichta 62.30 5.00e-29 120.00
IUUC-Tni-120134 Tetraodon nigroviridis 98.04 7.00e-76 276.00
IUUC-Tca-121524 Theobroma cacao 56.94 3.00e-37 148.00
IUUC-Tre-121915 Trichoderma reesei 67.69 2.00e-20 92.80
IUUC-Tvi-122411 Trichoderma virens 68.85 2.00e-18 85.90
IUUC-Tae-124851 Triticum aestivum 59.03 2.00e-35 142.00
IUUC-Tur-126821 Triticum urartu 58.33 3.00e-35 141.00
IUUC-Tme-126875 Tuber melanosporum 69.70 6.00e-21 93.60
IUUC-Tbe-127759 Tupaia belangeri 89.50 2.00e-65 241.00
IUUC-Ttr-129124 Tursiops truncatus 68.00 2.00e-60 228.00
IUUC-Uma-129551 Ustilago maydis 45.03 1.00e-26 112.00
IUUC-Vda-129992 Verticillium dahliae 70.31 6.00e-24 103.00
IUUC-Vpa-130096 Vicugna pacos 97.40 5.00e-73 266.00
IUUC-Vvi-130940 Vitis vinifera 57.97 1.00e-29 122.00
IUUC-Xtr-132454 Xenopus tropicalis 89.73 2.00e-88 318.00
IUUC-Xma-133842 Xiphophorus maculatus 90.38 2.00e-78 285.00
IUUC-Yli-134485 Yarrowia lipolytica 34.57 2.00e-21 95.50
IUUC-Zma-135748 Zea mays 57.64 4.00e-38 150.00
Created Date 25-Jun-2017

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