iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068541

Ensembl Protein ID

CADNFIAP00004818

UniProt Accession

A1DLM0; NACA_NEOFI

Genbank Protein ID

EAW15691.1

Protein Name

Nascent polypeptide-associated complex subunit alpha; Alpha-NAC

Genbank Nucleotide ID

DS027698

Gene Name

NFIA_050340; egd2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00004946	CADNFIAT00004946	CADNFIAP00004818

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	53.12	3.00e-16	79.70	IUUC-Sce-106371
UBD/Alpha-Helix/UBA	58.93	4.00e-14	72.40	IUUC-Spo-108121

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Neosartorya fischeri

Functional Description
(View)

Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Egd2 may also be involved in transcription regulation (By similarity).

Protein Sequence
(Fasta)

MADPRVEELP DEEVPKANVE DAGSDSESEA GEESSIPAGA AVTIHSRNEK KARKAIGKLG 60
LKHVPGITRV TLRRPKNILF VINQPDVYRS PSSNTWIIFG EAKIEDLNSQ AQASAAQQLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGATC CCCGTGTTGA AGAGCTCCCT GACGAGGAGG TTCCCAAGGC CAACGTCGAG 60
GACGCTGGCA GCGACTCTGA GTCCGAGGCT GGTGAGGAGT CCAGCATCCC CGCTGGCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom

PROSITE

PS51151--NAC_AB

Pfam

PF01849--NAC

SMART

SM01407--NAC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0015031--P:protein transport

KEGG

nfi:NFIA_050340

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001167	Aegilops tauschii	61.54	1.00e-17	81.30
IUUC-Aml-001719	Ailuropoda melanoleuca	70.31	2.00e-24	107.00
IUUC-Atr-002586	Amborella trichopoda	44.12	3.00e-11	60.10
IUUC-Apl-003190	Anas platyrhynchos	62.12	1.00e-21	93.60
IUUC-Aca-005265	Anolis carolinensis	70.31	4.00e-25	105.00
IUUC-Aly-006397	Arabidopsis lyrata	66.67	2.00e-08	50.10
IUUC-Ath-007378	Arabidopsis thaliana	61.54	1.00e-16	77.80
IUUC-Ago-007936	Ashbya gossypii	48.61	4.00e-18	82.40
IUUC-Acl-008036	Aspergillus clavatus	97.14	3.00e-46	176.00
IUUC-Afl-008462	Aspergillus flavus	91.67	8.00e-48	181.00
IUUC-Afu-008832	Aspergillus fumigatus	100.00	4.00e-43	165.00
IUUC-Ani-009246	Aspergillus nidulans	92.59	9.00e-48	181.00
IUUC-Ang-009808	Aspergillus niger	94.29	3.00e-46	176.00
IUUC-Aor-009972	Aspergillus oryzae	91.67	8.00e-48	181.00
IUUC-Ame-011674	Astyanax mexicanus	70.31	3.00e-25	106.00
IUUC-Bgr-012162	Blumeria graminis	62.73	3.00e-31	126.00
IUUC-Bta-012508	Bos taurus	70.31	3.00e-25	106.00
IUUC-Bci-013643	Botrytis cinerea	65.79	2.00e-33	134.00
IUUC-Bdi-014874	Brachypodium distachyon	61.54	1.00e-17	80.90
IUUC-Bol-015681	Brassica oleracea	59.26	1.00e-17	80.90
IUUC-Bra-017630	Brassica rapa	59.26	2.00e-17	80.90
IUUC-Cel-018111	Caenorhabditis elegans	47.83	1.00e-33	134.00
IUUC-Cja-019846	Callithrix jacchus	48.12	7.00e-30	125.00
IUUC-Cfa-020429	Canis familiaris	70.31	2.00e-25	107.00
IUUC-Cpo-022542	Cavia porcellus	70.31	4.00e-25	105.00
IUUC-Cre-022679	Chlamydomonas reinhardtii	64.29	2.00e-10	57.00
IUUC-Csa-023260	Chlorocebus sabaeus	48.12	3.00e-28	119.00
IUUC-Cho-024869	Choloepus hoffmanni	72.97	2.00e-10	57.40
IUUC-Cin-025166	Ciona intestinalis	49.38	1.00e-31	127.00
IUUC-Csv-026284	Ciona savignyi	69.81	6.00e-20	87.80
IUUC-Cgl-026520	Colletotrichum gloeosporioides	63.96	4.00e-33	132.00
IUUC-Cne-026920	Cryptococcus neoformans	63.01	1.00e-24	103.00
IUUC-Cme-027301	Cyanidioschyzon merolae	58.33	2.00e-19	87.40
IUUC-Dre-028709	Danio rerio	70.31	1.00e-24	107.00
IUUC-Dno-029786	Dasypus novemcinctus	70.31	4.00e-24	106.00
IUUC-Dor-030962	Dipodomys ordii	70.31	4.00e-25	105.00
IUUC-Dme-032061	Drosophila melanogaster	67.19	1.00e-22	98.20
IUUC-Ete-032965	Echinops telfairi	70.27	4.00e-10	56.20
IUUC-Eca-034049	Equus caballus	68.75	2.00e-24	103.00
IUUC-Eeu-034673	Erinaceus europaeus	70.31	3.00e-25	106.00
IUUC-Fca-036369	Felis catus	70.31	3.00e-24	106.00
IUUC-Fal-037006	Ficedula albicollis	70.31	4.00e-25	106.00
IUUC-Fox-037704	Fusarium oxysporum	65.18	2.00e-33	133.00
IUUC-Fso-038247	Fusarium solani	63.96	5.00e-33	132.00
IUUC-Gmo-039002	Gadus morhua	65.62	5.00e-22	95.90
IUUC-Ggr-039888	Gaeumannomyces graminis	62.14	2.00e-46	176.00
IUUC-Gga-040237	Gallus gallus	70.31	4.00e-25	106.00
IUUC-Gac-041800	Gasterosteus aculeatus	70.31	1.00e-24	105.00
IUUC-Gma-043275	Glycine max	64.06	1.00e-22	97.40
IUUC-Ggo-045163	Gorilla gorilla	62.50	1.00e-22	98.20
IUUC-Hsa-045795	Homo sapiens	70.31	4.00e-24	106.00
IUUC-Hvu-047376	Hordeum vulgare	61.54	2.00e-17	80.90
IUUC-Itr-048152	Ictidomys tridecemlineatus	70.31	3.00e-25	106.00
IUUC-Kpa-049166	Komagataella pastoris	56.16	3.00e-19	86.30
IUUC-Lch-050076	Latimeria chalumnae	70.31	2.00e-25	106.00
IUUC-Lpe-051258	Leersia perrieri	61.11	6.00e-19	85.50
IUUC-Loc-052292	Lepisosteus oculatus	70.31	2.00e-24	103.00
IUUC-Lma-053293	Leptosphaeria maculans	72.07	3.00e-38	149.00
IUUC-Laf-054393	Loxodonta africana	62.50	3.00e-23	99.80
IUUC-Mcc-054632	Macaca mulatta	70.31	6.00e-24	105.00
IUUC-Meu-056242	Macropus eugenii	70.31	2.00e-25	107.00
IUUC-Mor-057099	Magnaporthe oryzae	70.00	4.00e-34	135.00
IUUC-Mpo-057543	Magnaporthe poae	62.86	6.00e-27	111.00
IUUC-Mtr-058112	Medicago truncatula	47.17	1.00e-27	114.00
IUUC-Mla-059166	Melampsora laricipopulina	49.23	5.00e-14	68.90
IUUC-Mga-059406	Meleagris gallopavo	70.31	1.00e-24	104.00
IUUC-Mvi-060390	Microbotryum violaceum	38.71	8.00e-22	94.40
IUUC-Mmr-061569	Microcebus murinus	70.31	2.00e-25	106.00
IUUC-Mdo-062077	Monodelphis domestica	70.31	2.00e-24	105.00
IUUC-Mmu-063984	Mus musculus	70.31	2.00e-24	107.00
IUUC-Mac-065175	Musa acuminata	62.96	3.00e-19	86.30
IUUC-Mpu-065793	Mustela putorius furo	60.94	2.00e-18	87.80
IUUC-Mlu-068234	Myotis lucifugus	70.31	3.00e-25	106.00
IUUC-Ncr-068830	Neurospora crassa	72.07	8.00e-37	144.00
IUUC-Nle-069126	Nomascus leucogenys	70.31	4.00e-25	105.00
IUUC-Opr-070742	Ochotona princeps	70.31	3.00e-25	106.00
IUUC-Ont-071828	Oreochromis niloticus	70.31	9.00e-25	105.00
IUUC-Oan-073462	Ornithorhynchus anatinus	70.31	5.00e-24	105.00
IUUC-Ocu-074890	Oryctolagus cuniculus	47.50	2.00e-27	117.00
IUUC-Oba-075995	Oryza barthii	47.65	4.00e-27	112.00
IUUC-Obr-076073	Oryza brachyantha	47.65	1.00e-27	114.00
IUUC-Ogl-077445	Oryza glaberrima	47.65	4.00e-27	112.00
IUUC-Ogu-078606	Oryza glumaepatula	47.65	4.00e-27	112.00
IUUC-Oin-079287	Oryza indica	47.65	4.00e-27	112.00
IUUC-Olo-080686	Oryza longistaminata	45.21	7.00e-15	72.00
IUUC-Ome-081567	Oryza meridionalis	37.66	6.00e-22	94.70
IUUC-Oni-082873	Oryza nivara	47.65	4.00e-27	112.00
IUUC-Opu-083488	Oryza punctata	61.11	8.00e-19	85.10
IUUC-Oru-085045	Oryza rufipogon	37.66	6.00e-22	94.70
IUUC-Osa-086102	Oryza sativa	47.65	4.00e-27	112.00
IUUC-Ola-087531	Oryzias latipes	72.97	1.00e-10	58.20
IUUC-Olu-087895	Ostreococcus lucimarinus	56.00	1.00e-14	69.70
IUUC-Oga-088239	Otolemur garnettii	70.31	3.00e-25	106.00
IUUC-Oar-089723	Ovis aries	70.31	2.00e-24	107.00
IUUC-Ptr-090481	Pan troglodytes	51.25	7.00e-27	115.00
IUUC-Pan-092223	Papio anubis	70.31	4.00e-24	105.00
IUUC-Psi-093588	Pelodiscus sinensis	70.31	3.00e-25	106.00
IUUC-Pma-094702	Petromyzon marinus	70.31	4.00e-25	105.00
IUUC-Pno-094927	Phaeosphaeria nodorum	73.87	2.00e-39	153.00
IUUC-Ppa-095389	Physcomitrella patens	67.74	5.00e-22	95.90
IUUC-Pfo-096744	Poecilia formosa	70.31	4.00e-25	106.00
IUUC-Pab-098044	Pongo abelii	70.31	3.00e-25	106.00
IUUC-Pop-099938	Populus trichocarpa	62.96	1.00e-19	87.80
IUUC-Pca-100355	Procavia capensis	47.20	1.00e-27	117.00
IUUC-Ppe-101786	Prunus persica	47.65	2.00e-27	114.00
IUUC-Pva-102494	Pteropus vampyrus	70.31	3.00e-25	106.00
IUUC-Pgr-103303	Puccinia graminis	60.00	2.00e-19	87.00
IUUC-Ptt-103748	Puccinia triticina	59.09	3.00e-11	59.70
IUUC-Pte-104368	Pyrenophora teres	72.97	1.00e-38	150.00
IUUC-Pyt-104542	Pyrenophora triticirepentis	72.07	3.00e-38	149.00
IUUC-Rno-105387	Rattus norvegicus	70.31	2.00e-24	107.00
IUUC-Sce-106371	Saccharomyces cerevisiae	51.39	7.00e-19	84.70
IUUC-Sha-107189	Sarcophilus harrisii	70.31	3.00e-25	106.00
IUUC-Sja-107942	Schizosaccharomyces japonicus	50.00	2.00e-16	76.60
IUUC-Spo-108121	Schizosaccharomyces pombe	47.34	4.00e-30	122.00
IUUC-Ssl-108595	Sclerotinia sclerotiorum	62.28	2.00e-35	140.00
IUUC-Smo-108783	Selaginella moellendorffii	47.65	1.00e-26	111.00
IUUC-Sit-109728	Setaria italica	61.11	4.00e-18	82.80
IUUC-Sly-110957	Solanum lycopersicum	63.46	5.00e-18	82.40
IUUC-Stu-112873	Solanum tuberosum	61.54	3.00e-17	79.70
IUUC-Sar-113668	Sorex araneus	72.97	2.00e-10	57.40
IUUC-Sbi-114223	Sorghum bicolor	61.54	7.00e-18	82.00
IUUC-Sre-115220	Sporisorium reilianum	56.72	5.00e-19	85.50
IUUC-Ssc-116119	Sus scrofa	70.31	3.00e-25	106.00
IUUC-Tgu-116528	Taeniopygia guttata	70.31	3.00e-25	105.00
IUUC-Tru-117538	Takifugu rubripes	70.31	3.00e-25	106.00
IUUC-Tsy-118855	Tarsius syrichta	72.97	2.00e-10	57.00
IUUC-Tni-120134	Tetraodon nigroviridis	70.31	3.00e-25	106.00
IUUC-Tca-121524	Theobroma cacao	46.98	2.00e-27	113.00
IUUC-Tre-121915	Trichoderma reesei	62.28	4.00e-31	126.00
IUUC-Tvi-122411	Trichoderma virens	60.55	2.00e-27	114.00
IUUC-Tae-124851	Triticum aestivum	61.54	1.00e-17	81.30
IUUC-Tur-126821	Triticum urartu	61.54	2.00e-17	80.10
IUUC-Tme-126875	Tuber melanosporum	71.82	1.00e-34	137.00
IUUC-Tbe-127759	Tupaia belangeri	67.57	5.00e-09	52.40
IUUC-Ttr-129124	Tursiops truncatus	53.21	6.00e-28	118.00
IUUC-Uma-129551	Ustilago maydis	55.07	1.00e-19	87.40
IUUC-Vda-129992	Verticillium dahliae	65.37	3.00e-47	179.00
IUUC-Vpa-130096	Vicugna pacos	67.19	4.00e-22	96.30
IUUC-Vvi-130940	Vitis vinifera	63.46	1.00e-16	77.80
IUUC-Xtr-132454	Xenopus tropicalis	70.31	9.00e-25	105.00
IUUC-Xma-133842	Xiphophorus maculatus	70.31	6.00e-25	105.00
IUUC-Yli-134485	Yarrowia lipolytica	34.91	2.00e-15	73.90
IUUC-Zma-135748	Zea mays	61.11	4.00e-18	82.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence