iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000196998.17	ENST00000376358.4	ENSP00000365536.3
ENSG00000196998.17	ENST00000376372.8	ENSP00000365551.3
ENSG00000196998.17	ENST00000475977.2	ENSP00000417754.2
ENSG00000196998.17	ENST00000635003.1	ENSP00000489080.1
ENSG00000196998.17	ENST00000634838.1	ENSP00000489268.1
ENSG00000196998.17	ENST00000486337.6	ENSP00000419453.2
ENSG00000196998.17	ENST00000634559.1	ENSP00000488986.1
ENSG00000196998.17	ENST00000322995.13	ENSP00000365543.5
ENSG00000196998.17	ENST00000356463.7	ENSP00000348848.3
ENSG00000196998.17	ENST00000485908.6	ENSP00000419897.1
ENSG00000196998.17	ENST00000367375.8	ENSP00000356345.4
ENSG00000196998.17	ENST00000473974.5	ENSP00000417211.1
ENSG00000196998.17	ENST00000396681.9	ENSP00000379913.5
ENSG00000196998.17	ENST00000634736.1	ENSP00000489561.1
ENSG00000196998.17	ENST00000635666.1	ENSP00000489128.1
ENSG00000196998.17	ENST00000475880.6	ENSP00000418919.2
ENSG00000196998.17	ENST00000635344.1	ENSP00000489553.1
ENSG00000196998.17	ENST00000419567.7	ENSP00000393640.3
ENSG00000196998.17	ENST00000634522.1	ENSP00000489330.1
ENSG00000196998.17	ENST00000474053.6	ENSP00000420728.1
ENSG00000196998.17	ENST00000423215.3	ENSP00000397657.3
ENSG00000196998.17	ENST00000476728.5	ENSP00000419324.1
ENSG00000196998.17	ENST00000634849.1	ENSP00000489150.1
ENSG00000196998.17	ENST00000634671.1	ENSP00000489040.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Disease-associated Variation
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-09	38.0	202	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlr 31
           H++++ c+++  ++t ++s+s  gt i+++D+ 
   Q: 202  HQSDIACVSLnqPGTVVASASQKGTlIRLFDTQ 234
           9*********9877*****************76 PP

Organism

Homo sapiens

Functional Description
(View)

Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.

Protein Sequence
(Fasta)

MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS 60
NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT FTKPVLSVRM RHDKIVIVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAGTGCCT GGGCTCCGGG AAAGTCGTGC TTTTACGGTT CCGGGTACTG GCTCCCACAC 60
CACTGCCTCG TGTGGGGTTG TTCGCCCGTG AAGGGGCAGG ACAGGGTGCG CGCTGGTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0523--Neurodegeneration
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032910--WIPI4

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0006914--P:autophagy

KEGG

hsa:11152

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001633	Ailuropoda melanoleuca	95.69	0.00e+00	734.00
IUUC-Aca-005110	Anolis carolinensis	90.84	0.00e+00	699.00
IUUC-Bta-013273	Bos taurus	96.23	0.00e+00	736.00
IUUC-Cja-018761	Callithrix jacchus	98.92	0.00e+00	761.00
IUUC-Cfa-020565	Canis familiaris	95.15	0.00e+00	727.00
IUUC-Cpo-021801	Cavia porcellus	95.42	0.00e+00	730.00
IUUC-Csa-023657	Chlorocebus sabaeus	97.04	0.00e+00	739.00
IUUC-Cin-025682	Ciona intestinalis	57.85	6.00e-122	430.00
IUUC-Dre-027718	Danio rerio	87.33	0.00e+00	674.00
IUUC-Dno-029199	Dasypus novemcinctus	95.15	0.00e+00	725.00
IUUC-Dor-030931	Dipodomys ordii	95.38	0.00e+00	708.00
IUUC-Ete-032303	Echinops telfairi	97.86	0.00e+00	660.00
IUUC-Eca-034053	Equus caballus	95.42	0.00e+00	731.00
IUUC-Fca-036502	Felis catus	95.70	0.00e+00	730.00
IUUC-Gmo-038583	Gadus morhua	87.06	0.00e+00	672.00
IUUC-Gac-042546	Gasterosteus aculeatus	87.15	0.00e+00	645.00
IUUC-Ggo-045610	Gorilla gorilla	100.00	0.00e+00	772.00
IUUC-Itr-048533	Ictidomys tridecemlineatus	95.69	0.00e+00	733.00
IUUC-Lch-050439	Latimeria chalumnae	85.91	0.00e+00	663.00
IUUC-Loc-052269	Lepisosteus oculatus	88.14	0.00e+00	679.00
IUUC-Laf-054475	Loxodonta africana	95.42	0.00e+00	730.00
IUUC-Mcc-055829	Macaca mulatta	97.04	0.00e+00	739.00
IUUC-Mmr-061021	Microcebus murinus	95.76	0.00e+00	745.00
IUUC-Mmu-063935	Mus musculus	94.88	0.00e+00	727.00
IUUC-Mpu-066555	Mustela putorius furo	95.96	0.00e+00	736.00
IUUC-Mlu-067797	Myotis lucifugus	94.07	0.00e+00	716.00
IUUC-Ont-071532	Oreochromis niloticus	87.60	0.00e+00	677.00
IUUC-Ola-086343	Oryzias latipes	86.25	0.00e+00	667.00
IUUC-Oga-088001	Otolemur garnettii	95.96	0.00e+00	734.00
IUUC-Oar-090011	Ovis aries	97.57	0.00e+00	743.00
IUUC-Pan-092470	Papio anubis	97.04	0.00e+00	739.00
IUUC-Pma-094403	Petromyzon marinus	78.12	8.00e-168	583.00
IUUC-Pfo-096982	Poecilia formosa	86.79	0.00e+00	671.00
IUUC-Pca-100176	Procavia capensis	87.60	0.00e+00	656.00
IUUC-Pva-102156	Pteropus vampyrus	97.04	0.00e+00	744.00
IUUC-Rno-105782	Rattus norvegicus	95.42	0.00e+00	731.00
IUUC-Ssc-116318	Sus scrofa	96.23	0.00e+00	736.00
IUUC-Tru-118633	Takifugu rubripes	87.33	0.00e+00	673.00
IUUC-Tsy-119533	Tarsius syrichta	99.03	2.00e-120	424.00
IUUC-Tni-119984	Tetraodon nigroviridis	88.49	0.00e+00	675.00
IUUC-Ttr-128703	Tursiops truncatus	97.76	9.00e-128	449.00
IUUC-Xtr-131754	Xenopus tropicalis	84.91	2.00e-180	624.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence