iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046169

UUCD1 version

UUC-HoS-00452

Ensembl Protein ID

ENSP00000351250.2

UniProt Accession

Q9UPN9; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; TRI33_HUMAN

Genbank Protein ID

AAD17259.1; AAG53509.1; AAG53510.1; BAA83065.1; CAI13548.1; CAI13548.1; CAI13550.1; CAI13550.1; CAI13551.1; CAI13551.1; CAI21895.1; CAI21895.1; CAI21896.1; CAI21896.1; CAI21897.1; CAI21897.1; CAB55313.1

Protein Name

E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; RET-fused gene 7 protein; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; Tripartite motif-containing protein 33

Genbank Nucleotide ID

AF119043; AF220136; AF220137; AB029036; AL390241; AL035410; AL390241; AL035410; AL390241; AL035410; AL035410; AL390241; AL035410; AL390241; AL035410; AL390241; AJ132948

Gene Name

TRIM33; KIAA1113; RFG7; TIF1G

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197323.11	ENST00000358465.6	ENSP00000351250.2
ENSG00000197323.11	ENST00000448034.5	ENSP00000402333.1
ENSG00000197323.11	ENST00000369543.6	ENSP00000358556.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15820681; 17189380; 20447379; 21726812; 24881051
E3 activity/RING/PHD	PHD	15820681; 17189380; 21726812; 24881051

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	1.00e-08	36.9	888	933
E3 activity/RING/RING	1.10e-05	27.5	125	185

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C+vC++gg+    l++CekC ++fH +C+ ++   ++p+ + wiC+ Cr+
   Q: 888  DWCAVCQNGGD----LLCCEKCPKVFHLTCHVPT-LLSFPSGD-WICTFCRD 933
           79*********....*******************.*******7.******85 PP

E3 activity/RING/RING

   S: 1    CaiCledf....kdgplvlpCgHvfhadCl...qkw........pglknssskefrCPlCr 46
           Ca+C++++    + +p++lpC H f++ Cl   ++          +   ++ + +rCP+Cr
   Q: 125  CAVCQQSLqsrrEAEPKLLPCLHSFCLRCLpepERQlsvpipggSNGDIQQVGVIRCPVCR 185
           ******999888556***************88844468888666555556667779****8 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Protein Sequence
(Fasta)

MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLTA VLVEEEEEEG GRAGAEGGAA 60
GPDDGGVAAA SSGSAQAASS PAASVGTGVA GGAVSTPAPA PASAPAPGPS AGPPPGPPAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCGGCTGG GGCTGGGGGC GGCGGCGGCG GCGACGCGGG CGGCGGGCGG CGCGGGGCGG 60
TCCGGCGGGT TCAAAGAGGA AAACATGGCG GAAAACAAAG GCGGCGGCGA GGCTGAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR00503--BROMODOMAIN

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070410--F:co-SMAD binding
GO:0003677--F:DNA binding
GO:0070412--F:R-SMAD binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016567--P:protein ubiquitination
GO:0017015--P:regulation of transforming growth factor beta receptor signaling pathway
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:51592

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002364	Ailuropoda melanoleuca	98.22	0.00e+00	1746.00
IUUC-Apl-003894	Anas platyrhynchos	91.46	0.00e+00	1602.00
IUUC-Aca-004658	Anolis carolinensis	90.25	0.00e+00	1563.00
IUUC-Ame-011619	Astyanax mexicanus	60.34	0.00e+00	1060.00
IUUC-Bta-013341	Bos taurus	96.23	0.00e+00	1702.00
IUUC-Cja-018733	Callithrix jacchus	99.30	0.00e+00	1775.00
IUUC-Cfa-020725	Canis familiaris	99.10	0.00e+00	1720.00
IUUC-Cpo-021833	Cavia porcellus	98.41	0.00e+00	1742.00
IUUC-Csa-023040	Chlorocebus sabaeus	99.80	0.00e+00	1721.00
IUUC-Cho-024934	Choloepus hoffmanni	95.79	0.00e+00	1626.00
IUUC-Cin-025200	Ciona intestinalis	31.97	2.00e-45	178.00
IUUC-Csv-026278	Ciona savignyi	47.25	5.00e-20	91.30
IUUC-Dre-027797	Danio rerio	73.18	2.00e-172	600.00
IUUC-Dno-028955	Dasypus novemcinctus	98.11	0.00e+00	1805.00
IUUC-Dme-032143	Drosophila melanogaster	31.98	4.00e-45	177.00
IUUC-Ete-032728	Echinops telfairi	95.87	0.00e+00	926.00
IUUC-Eca-033573	Equus caballus	98.02	0.00e+00	1723.00
IUUC-Eeu-035138	Erinaceus europaeus	86.42	0.00e+00	828.00
IUUC-Fca-035776	Felis catus	98.95	0.00e+00	1632.00
IUUC-Fal-037583	Ficedula albicollis	91.53	0.00e+00	1632.00
IUUC-Gmo-039353	Gadus morhua	61.97	0.00e+00	663.00
IUUC-Gga-040874	Gallus gallus	92.06	0.00e+00	1707.00
IUUC-Gac-041689	Gasterosteus aculeatus	55.93	0.00e+00	1103.00
IUUC-Ggo-045151	Gorilla gorilla	99.16	0.00e+00	1335.00
IUUC-Itr-048377	Ictidomys tridecemlineatus	97.95	0.00e+00	751.00
IUUC-Lch-050411	Latimeria chalumnae	81.69	0.00e+00	1381.00
IUUC-Loc-051992	Lepisosteus oculatus	71.98	0.00e+00	1295.00
IUUC-Laf-054552	Loxodonta africana	98.32	0.00e+00	1653.00
IUUC-Mcc-055744	Macaca mulatta	99.70	0.00e+00	1716.00
IUUC-Meu-056647	Macropus eugenii	99.15	0.00e+00	707.00
IUUC-Mga-059589	Meleagris gallopavo	92.49	0.00e+00	959.00
IUUC-Mmr-060727	Microcebus murinus	99.60	0.00e+00	1751.00
IUUC-Mdo-063029	Monodelphis domestica	96.43	0.00e+00	1751.00
IUUC-Mmu-064033	Mus musculus	96.92	0.00e+00	1762.00
IUUC-Mpu-066679	Mustela putorius furo	98.61	0.00e+00	1736.00
IUUC-Mlu-067286	Myotis lucifugus	97.79	0.00e+00	1633.00
IUUC-Nle-069156	Nomascus leucogenys	99.50	0.00e+00	1714.00
IUUC-Opr-070309	Ochotona princeps	87.85	0.00e+00	1279.00
IUUC-Ont-071586	Oreochromis niloticus	54.27	0.00e+00	1048.00
IUUC-Oan-073205	Ornithorhynchus anatinus	94.85	0.00e+00	1460.00
IUUC-Ocu-074667	Oryctolagus cuniculus	96.03	0.00e+00	1622.00
IUUC-Ola-086481	Oryzias latipes	67.23	3.00e-165	576.00
IUUC-Oga-089101	Otolemur garnettii	98.41	0.00e+00	1732.00
IUUC-Oar-090167	Ovis aries	98.21	0.00e+00	1748.00
IUUC-Ptr-090901	Pan troglodytes	99.90	0.00e+00	1724.00
IUUC-Pan-092448	Papio anubis	97.62	0.00e+00	1717.00
IUUC-Psi-093657	Pelodiscus sinensis	91.76	0.00e+00	1483.00
IUUC-Pma-094506	Petromyzon marinus	65.91	1.00e-50	191.00
IUUC-Pfo-097104	Poecilia formosa	69.15	7.00e-160	558.00
IUUC-Pab-097704	Pongo abelii	99.80	0.00e+00	1758.00
IUUC-Pca-101001	Procavia capensis	88.16	0.00e+00	652.00
IUUC-Pva-102733	Pteropus vampyrus	94.18	0.00e+00	1566.00
IUUC-Rno-105512	Rattus norvegicus	97.91	0.00e+00	1757.00
IUUC-Sha-107423	Sarcophilus harrisii	95.41	0.00e+00	1625.00
IUUC-Sar-113181	Sorex araneus	89.25	9.00e-146	511.00
IUUC-Ssc-116330	Sus scrofa	93.28	0.00e+00	1525.00
IUUC-Tgu-117388	Taeniopygia guttata	75.97	0.00e+00	1267.00
IUUC-Tru-118728	Takifugu rubripes	57.48	0.00e+00	978.00
IUUC-Tsy-119053	Tarsius syrichta	98.73	0.00e+00	1052.00
IUUC-Tni-120279	Tetraodon nigroviridis	47.81	3.00e-162	565.00
IUUC-Tbe-127573	Tupaia belangeri	90.04	0.00e+00	840.00
IUUC-Ttr-128594	Tursiops truncatus	98.31	0.00e+00	1743.00
IUUC-Vpa-130619	Vicugna pacos	92.32	0.00e+00	1097.00
IUUC-Xtr-132837	Xenopus tropicalis	85.02	0.00e+00	1499.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence