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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046760
Ensembl Protein ID ENSP00000352185.4
UniProt Accession O75151; Q4VXG0; Q8N3K2; Q9Y6N4; PHF2_HUMAN
Genbank Protein ID AAD21791.1; BAA31637.2; CAI96110.1; CAI96110.1; CAI96111.1; CAI96111.1; EAW62867.1; CAD38938.1
Protein Name Lysine-specific demethylase PHF2; GRC5; PHD finger protein 2
Genbank Nucleotide ID AF043725; AB014562; AL353629; AL359181; AL359181; AL353629; CH471089; AL834263
Gene Name PHF2; CENP-35; KIAA0662
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000197724.10 ENST00000359246.8 ENSP00000352185.4
ENSG00000197724.10 ENST00000610682.1 ENSP00000479936.1
ENSG00000197724.10 ENST00000375376.8 ENSP00000364525.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.40e-09 39.6 6 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C vC+ +++ ++ ++eC+ C++wfH  C++ + eee p+ + + Cp+C++
   Q: 6    VYC-VCRLPYDVTRFMIECDACKDWFHGSCVGVE-EEEAPDIDIYHCPNCEK 55
           69*.******************************.*******99******86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
 Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Protein Sequence
(Fasta)
MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 60
TLKKKRTWHK HGPGQAPDVK PVQNGSQLFI KELRSRTFPS AEDVVARVPG SQLTLGYMEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046760|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCCGCTCGG CGGCCGGGGG TCCCTTCGGT GGGGCCGCGG CTCCCCGCCC GCCGCCCCCG 60
CGCGTCCATT CCCTTTTGTG TCCCGCGCGC GGCCCGTCCC CCGCGCACAC TAGCGCCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046760|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0995--Kinetochore
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
SMART

SM00558--JmjC
SM00249--PHD
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0032452--F:histone demethylase activity
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0001889--P:liver development
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0006482--P:protein demethylation
GO:0006351--P:transcription, DNA-templated
KEGG hsa:5253
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002986 Amborella trichopoda 37.18 6.00e-12 64.30
IUUC-Aca-005043 Anolis carolinensis 89.78 0.00e+00 889.00
IUUC-Aly-005443 Arabidopsis lyrata 35.82 2.00e-11 62.40
IUUC-Bdi-014153 Brachypodium distachyon 43.64 1.00e-12 66.20
IUUC-Bol-015887 Brassica oleracea 48.00 4.00e-12 64.70
IUUC-Dre-028285 Danio rerio 79.96 0.00e+00 768.00
IUUC-Fal-037017 Ficedula albicollis 89.13 0.00e+00 922.00
IUUC-Gga-040290 Gallus gallus 89.13 0.00e+00 922.00
IUUC-Gma-042998 Glycine max 36.76 1.00e-11 62.80
IUUC-Hvu-047723 Hordeum vulgare 32.84 4.00e-10 58.20
IUUC-Lpe-051400 Leersia perrieri 45.45 2.00e-12 65.90
IUUC-Loc-051927 Lepisosteus oculatus 83.81 0.00e+00 848.00
IUUC-Mtr-057710 Medicago truncatula 38.46 2.00e-11 62.80
IUUC-Mmr-061132 Microcebus murinus 95.86 0.00e+00 1668.00
IUUC-Mmu-063458 Mus musculus 93.52 0.00e+00 1652.00
IUUC-Mac-065355 Musa acuminata 45.10 1.00e-11 63.20
IUUC-Ont-071935 Oreochromis niloticus 77.26 0.00e+00 742.00
IUUC-Oba-075188 Oryza barthii 45.45 6.00e-12 64.30
IUUC-Obr-076844 Oryza brachyantha 45.45 5.00e-12 64.30
IUUC-Ogl-077260 Oryza glaberrima 45.45 5.00e-12 64.30
IUUC-Ogu-078663 Oryza glumaepatula 45.45 2.00e-12 65.90
IUUC-Oin-079894 Oryza indica 45.45 2.00e-12 65.90
IUUC-Olo-080411 Oryza longistaminata 45.45 2.00e-12 65.50
IUUC-Ome-081623 Oryza meridionalis 45.45 3.00e-12 65.10
IUUC-Oni-082587 Oryza nivara 45.45 2.00e-12 65.90
IUUC-Opu-083591 Oryza punctata 43.64 4.00e-12 64.70
IUUC-Oru-084597 Oryza rufipogon 45.45 2.00e-12 65.90
IUUC-Osa-086057 Oryza sativa 45.45 2.00e-12 65.90
IUUC-Ola-087236 Oryzias latipes 78.27 0.00e+00 766.00
IUUC-Ptr-091328 Pan troglodytes 90.78 0.00e+00 1152.00
IUUC-Pfo-096227 Poecilia formosa 77.05 0.00e+00 766.00
IUUC-Pop-098853 Populus trichocarpa 44.00 2.00e-11 62.40
IUUC-Ppe-101818 Prunus persica 37.66 5.00e-12 64.30
IUUC-Spo-108120 Schizosaccharomyces pombe 35.57 1.00e-49 191.00
IUUC-Sit-110411 Setaria italica 47.46 7.00e-14 70.50
IUUC-Sly-110932 Solanum lycopersicum 35.06 3.00e-12 65.50
IUUC-Stu-112357 Solanum tuberosum 40.68 2.00e-11 62.80
IUUC-Sbi-114098 Sorghum bicolor 49.09 2.00e-13 69.30
IUUC-Tgu-117091 Taeniopygia guttata 88.70 0.00e+00 916.00
IUUC-Tru-118118 Takifugu rubripes 63.22 0.00e+00 1128.00
IUUC-Tni-120632 Tetraodon nigroviridis 75.88 0.00e+00 798.00
IUUC-Tca-121518 Theobroma cacao 48.00 5.00e-12 64.30
IUUC-Tae-125802 Triticum aestivum 43.64 1.00e-12 67.00
IUUC-Tur-126461 Triticum urartu 43.64 1.00e-12 66.20
IUUC-Ttr-128194 Tursiops truncatus 93.08 0.00e+00 1620.00
IUUC-Vvi-131614 Vitis vinifera 48.00 6.00e-12 64.30
IUUC-Xma-134037 Xiphophorus maculatus 77.05 0.00e+00 766.00
Created Date 25-Jun-2017

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