iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198554.11	ENST00000360586.7	ENSP00000353793.3
ENSG00000198554.11	ENST00000567693.1	ENSP00000456806.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-13	52.5	134	170

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtl.lvsGsdDgtikvWDlrtgvl 35
           gH ++v +l+f + ++ l+s+s Dg+++vW ++++++
   Q: 134  GHDAPVLSLSFdPKDIfLASASCDGSVRVWQISDQTC 170
           8**********7444447************9998887 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.

Protein Sequence
(Fasta)

MPATRKPMRY GHTEGHTEVC FDDSGSFIVT CGSDGDVRIW EDLDDDDPKF INVGEKAYSC 60
ALKSGKLVTA VSNNTIQVHT FPEGVPDGIL TRFTTNANHV VFNGDGTKIA AGSSDFLVKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGCAGTG TGGTGAGCGA GCCGAAGCGC GGGAAGCAGC TCTTGTGGAT CCTCAGTGGC 60
GGAGGCTCGG TCACCCGGGT GAGTCCCCAC TCCGGCTGCC CGCGTCCACC AAGGAGATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR009071--HMG_box_dom
IPR022100--Mcl1_mid
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50118--HMG_BOX_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF12341--Mcl1_mid
PF00400--WD40

SMART

SM00398--HMG
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding

KEGG

hsa:11169

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000357	Aegilops tauschii	29.07	9.00e-72	265.00
IUUC-Aml-001369	Ailuropoda melanoleuca	89.29	0.00e+00	1956.00
IUUC-Atr-002987	Amborella trichopoda	28.61	3.00e-78	286.00
IUUC-Apl-003331	Anas platyrhynchos	69.10	0.00e+00	1517.00
IUUC-Aca-004285	Anolis carolinensis	65.24	0.00e+00	1459.00
IUUC-Aly-005907	Arabidopsis lyrata	29.88	1.00e-67	251.00
IUUC-Ath-007037	Arabidopsis thaliana	29.02	7.00e-66	246.00
IUUC-Acl-008185	Aspergillus clavatus	25.29	4.00e-30	127.00
IUUC-Afl-008630	Aspergillus flavus	22.43	4.00e-55	209.00
IUUC-Afu-008921	Aspergillus fumigatus	23.58	2.00e-54	207.00
IUUC-Ani-009243	Aspergillus nidulans	22.05	4.00e-52	199.00
IUUC-Ang-009860	Aspergillus niger	25.54	2.00e-31	130.00
IUUC-Aor-010029	Aspergillus oryzae	22.43	4.00e-55	209.00
IUUC-Ate-010570	Aspergillus terreus	25.67	5.00e-33	136.00
IUUC-Bgr-012205	Blumeria graminis	25.65	3.00e-31	130.00
IUUC-Bta-012495	Bos taurus	87.18	0.00e+00	1933.00
IUUC-Bci-013848	Botrytis cinerea	23.33	2.00e-24	108.00
IUUC-Bdi-014162	Brachypodium distachyon	27.56	6.00e-73	269.00
IUUC-Bol-015828	Brassica oleracea	27.51	9.00e-64	238.00
IUUC-Bra-016792	Brassica rapa	29.31	1.00e-60	228.00
IUUC-Cja-018995	Callithrix jacchus	94.96	0.00e+00	2119.00
IUUC-Cfa-020713	Canis familiaris	89.58	0.00e+00	1797.00
IUUC-Cpo-021596	Cavia porcellus	76.41	0.00e+00	1630.00
IUUC-Cre-022785	Chlamydomonas reinhardtii	27.61	2.00e-19	92.00
IUUC-Csa-024080	Chlorocebus sabaeus	97.20	0.00e+00	2058.00
IUUC-Cho-024295	Choloepus hoffmanni	82.14	0.00e+00	709.00
IUUC-Cin-025123	Ciona intestinalis	48.56	3.00e-116	412.00
IUUC-Csv-025859	Ciona savignyi	46.94	2.00e-114	407.00
IUUC-Cgl-026546	Colletotrichum gloeosporioides	24.65	1.00e-26	115.00
IUUC-Cne-026873	Cryptococcus neoformans	28.57	4.00e-42	167.00
IUUC-Dre-028752	Danio rerio	57.71	0.00e+00	1216.00
IUUC-Dno-029844	Dasypus novemcinctus	80.41	0.00e+00	1722.00
IUUC-Dse-031515	Dothistroma septosporum	23.63	4.00e-54	206.00
IUUC-Dme-031614	Drosophila melanogaster	33.25	2.00e-56	214.00
IUUC-Ete-032291	Echinops telfairi	84.77	4.00e-154	539.00
IUUC-Eca-033665	Equus caballus	88.43	0.00e+00	1978.00
IUUC-Eeu-035036	Erinaceus europaeus	75.35	0.00e+00	823.00
IUUC-Fca-036209	Felis catus	89.12	0.00e+00	1969.00
IUUC-Fal-037229	Ficedula albicollis	67.28	0.00e+00	1486.00
IUUC-Fox-037686	Fusarium oxysporum	25.66	3.00e-28	119.00
IUUC-Fso-038120	Fusarium solani	26.51	1.00e-28	122.00
IUUC-Gmo-039627	Gadus morhua	60.16	5.00e-174	605.00
IUUC-Ggr-040058	Gaeumannomyces graminis	28.80	7.00e-25	109.00
IUUC-Gga-040825	Gallus gallus	69.61	0.00e+00	1501.00
IUUC-Gac-042000	Gasterosteus aculeatus	49.09	0.00e+00	979.00
IUUC-Gma-042961	Glycine max	29.95	5.00e-38	153.00
IUUC-Ggo-044531	Gorilla gorilla	99.20	0.00e+00	2223.00
IUUC-Hvu-047719	Hordeum vulgare	28.95	6.00e-72	266.00
IUUC-Itr-048089	Ictidomys tridecemlineatus	89.26	0.00e+00	811.00
IUUC-Lch-050106	Latimeria chalumnae	62.32	0.00e+00	1341.00
IUUC-Lpe-050996	Leersia perrieri	27.52	8.00e-71	262.00
IUUC-Loc-051766	Lepisosteus oculatus	58.76	0.00e+00	1304.00
IUUC-Lma-053144	Leptosphaeria maculans	23.13	5.00e-19	90.10
IUUC-Laf-054285	Loxodonta africana	86.72	0.00e+00	1868.00
IUUC-Mcc-054702	Macaca mulatta	97.79	0.00e+00	2121.00
IUUC-Meu-056634	Macropus eugenii	67.65	0.00e+00	688.00
IUUC-Mor-057040	Magnaporthe oryzae	23.16	1.00e-50	195.00
IUUC-Mpo-057395	Magnaporthe poae	27.83	2.00e-24	108.00
IUUC-Mtr-057830	Medicago truncatula	26.71	7.00e-71	262.00
IUUC-Mla-059152	Melampsora laricipopulina	23.90	3.00e-25	111.00
IUUC-Mga-059492	Meleagris gallopavo	69.55	0.00e+00	1528.00
IUUC-Mvi-060303	Microbotryum violaceum	27.74	2.00e-38	155.00
IUUC-Mmr-061066	Microcebus murinus	90.64	0.00e+00	2008.00
IUUC-Mdo-062039	Monodelphis domestica	74.43	0.00e+00	1618.00
IUUC-Mmu-063620	Mus musculus	83.27	0.00e+00	1828.00
IUUC-Mac-065638	Musa acuminata	27.38	3.00e-74	273.00
IUUC-Mpu-066212	Mustela putorius furo	84.01	0.00e+00	1867.00
IUUC-Mlu-068167	Myotis lucifugus	88.15	0.00e+00	1891.00
IUUC-Nfi-068338	Neosartorya fischeri	23.95	2.00e-53	204.00
IUUC-Ncr-068798	Neurospora crassa	23.45	9.00e-22	99.40
IUUC-Nle-069987	Nomascus leucogenys	97.70	0.00e+00	2148.00
IUUC-Opr-070369	Ochotona princeps	83.14	2.00e-127	450.00
IUUC-Ont-072317	Oreochromis niloticus	59.12	0.00e+00	1253.00
IUUC-Oan-073516	Ornithorhynchus anatinus	83.52	3.00e-140	491.00
IUUC-Ocu-074529	Oryctolagus cuniculus	87.10	0.00e+00	1954.00
IUUC-Oba-075044	Oryza barthii	28.02	5.00e-66	246.00
IUUC-Obr-076499	Oryza brachyantha	28.77	4.00e-64	240.00
IUUC-Ogl-077757	Oryza glaberrima	27.51	6.00e-66	246.00
IUUC-Ogu-078878	Oryza glumaepatula	28.28	1.00e-66	248.00
IUUC-Oin-079900	Oryza indica	28.77	1.00e-66	248.00
IUUC-Olo-080741	Oryza longistaminata	28.75	3.00e-66	247.00
IUUC-Ome-081734	Oryza meridionalis	28.41	2.00e-66	248.00
IUUC-Oni-082656	Oryza nivara	29.28	2.00e-66	247.00
IUUC-Opu-083312	Oryza punctata	27.30	8.00e-65	242.00
IUUC-Oru-084507	Oryza rufipogon	27.74	2.00e-66	247.00
IUUC-Osa-085329	Oryza sativa	27.36	1.00e-58	221.00
IUUC-Ola-086433	Oryzias latipes	64.68	0.00e+00	1083.00
IUUC-Olu-087690	Ostreococcus lucimarinus	27.18	3.00e-35	143.00
IUUC-Oga-088410	Otolemur garnettii	83.82	0.00e+00	1792.00
IUUC-Oar-089993	Ovis aries	86.47	0.00e+00	1903.00
IUUC-Ptr-091145	Pan troglodytes	99.47	0.00e+00	2196.00
IUUC-Pan-092500	Papio anubis	97.61	0.00e+00	2118.00
IUUC-Psi-093984	Pelodiscus sinensis	72.94	0.00e+00	1604.00
IUUC-Pma-094567	Petromyzon marinus	50.43	0.00e+00	669.00
IUUC-Pno-095002	Phaeosphaeria nodorum	25.34	6.00e-19	89.70
IUUC-Pfo-097387	Poecilia formosa	55.61	0.00e+00	1009.00
IUUC-Pab-097803	Pongo abelii	98.67	0.00e+00	2145.00
IUUC-Pop-099165	Populus trichocarpa	28.04	2.00e-68	254.00
IUUC-Pca-100989	Procavia capensis	68.75	2.00e-167	583.00
IUUC-Ppe-102022	Prunus persica	28.18	8.00e-70	259.00
IUUC-Pva-102389	Pteropus vampyrus	83.20	0.00e+00	1835.00
IUUC-Pgr-103635	Puccinia graminis	25.84	9.00e-31	129.00
IUUC-Ptt-103730	Puccinia triticina	27.35	1.00e-29	125.00
IUUC-Pte-104320	Pyrenophora teres	24.51	2.00e-39	157.00
IUUC-Pyt-104622	Pyrenophora triticirepentis	23.57	9.00e-36	145.00
IUUC-Rno-105689	Rattus norvegicus	81.50	0.00e+00	1803.00
IUUC-Sha-107448	Sarcophilus harrisii	75.50	0.00e+00	1598.00
IUUC-Sja-107702	Schizosaccharomyces japonicus	25.43	2.00e-49	191.00
IUUC-Spo-108360	Schizosaccharomyces pombe	25.83	2.00e-53	204.00
IUUC-Ssl-108529	Sclerotinia sclerotiorum	22.90	3.00e-43	170.00
IUUC-Smo-109337	Selaginella moellendorffii	27.25	1.00e-64	241.00
IUUC-Sit-110790	Setaria italica	29.03	2.00e-36	147.00
IUUC-Sly-111470	Solanum lycopersicum	27.31	4.00e-68	253.00
IUUC-Stu-111945	Solanum tuberosum	26.99	4.00e-70	259.00
IUUC-Sar-113075	Sorex araneus	74.82	0.00e+00	1368.00
IUUC-Sbi-114822	Sorghum bicolor	29.33	5.00e-63	236.00
IUUC-Sre-114913	Sporisorium reilianum	23.58	1.00e-36	149.00
IUUC-Ssc-116073	Sus scrofa	85.59	0.00e+00	1675.00
IUUC-Tgu-117253	Taeniopygia guttata	73.49	0.00e+00	1260.00
IUUC-Tru-117741	Takifugu rubripes	57.76	0.00e+00	1173.00
IUUC-Tsy-118834	Tarsius syrichta	93.51	0.00e+00	764.00
IUUC-Tni-120726	Tetraodon nigroviridis	56.66	0.00e+00	1192.00
IUUC-Tca-121655	Theobroma cacao	27.20	6.00e-74	272.00
IUUC-Tre-121921	Trichoderma reesei	24.01	6.00e-27	116.00
IUUC-Tvi-122540	Trichoderma virens	23.60	2.00e-25	111.00
IUUC-Tae-123225	Triticum aestivum	28.52	5.00e-72	266.00
IUUC-Tur-126398	Triticum urartu	28.81	6.00e-70	259.00
IUUC-Tme-127075	Tuber melanosporum	23.97	3.00e-57	216.00
IUUC-Tbe-128002	Tupaia belangeri	85.67	2.00e-162	566.00
IUUC-Ttr-129101	Tursiops truncatus	84.19	0.00e+00	1793.00
IUUC-Uma-129374	Ustilago maydis	23.87	2.00e-24	108.00
IUUC-Vda-129719	Verticillium dahliae	25.08	3.00e-24	107.00
IUUC-Vpa-130039	Vicugna pacos	87.36	0.00e+00	1917.00
IUUC-Vvi-131442	Vitis vinifera	27.91	4.00e-58	220.00
IUUC-Xtr-132599	Xenopus tropicalis	63.68	0.00e+00	1419.00
IUUC-Xma-132991	Xiphophorus maculatus	58.43	0.00e+00	1226.00
IUUC-Zma-135846	Zea mays	28.33	1.00e-69	258.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence