iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046560

Ensembl Protein ID

ENSP00000371859.2

UniProt Accession

Q9NRL2; Q9NZ15; Q9P065; Q9UIG1; Q9Y3V3; BAZ1A_HUMAN

Genbank Protein ID

AAF70601.1; AAF32366.1; BAA89209.1; EAW65900.1; AAF28995.1; CAB43261.1

Protein Name

Bromodomain adjacent to zinc finger domain protein 1A; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; CHRAC subunit ACF1; Williams syndrome transcription factor-related chromatin-remodeling factor 180; hWALp1

Genbank Nucleotide ID

AF213467; AF221130; AB032252; AL121603; AF161435; AL050089

Gene Name

BAZ1A; ACF1; WCRF180; HSPC317

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198604.10	ENST00000358716.8	ENSP00000351555.4
ENSG00000198604.10	ENST00000382422.6	ENSP00000371859.2
ENSG00000198604.10	ENST00000555331.1	ENSP00000450902.1
ENSG00000198604.10	ENST00000554865.1	ENSP00000450923.1
ENSG00000198604.10	ENST00000556314.2	ENSP00000480380.1
ENSG00000198604.10	ENST00000553573.1	ENSP00000451896.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRecords	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.00e-08	36.9	1149	1197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           + C++C+++g+ e ++v C+ C++  H  C+ ++  +++p+ + w+Cp+Cr 
   Q: 1149 ARCKICRKKGDAE-NMVLCDGCDRGHHTYCVRPK-LKTVPEGD-WFCPECRP 1197
           57*********98.6*******************.*******7.******96 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the ACF chromatin remodeling complex that includes BAZ1A and SMARCA5. Additional this complex can form, together with CHRAC1 and POLE1, the histone-fold protein complex, CHRAC. Interacts with NCOR1 (via its RD1 domain); the interaction corepresses a number of NCOR1-regulated genes.

Protein Sequence
(Fasta)

MPLLHRKPFV RQKPPADLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL VWSCAVTGRP 60
GLTYQEALES EKKARQNLQS FPEPLIIPVL YLTSLTHRSR LHEICDDIFA YVKDRYFVEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTCCCAT CGTGTAGTCA AGAGTCTGTG CCAGACTTGA AGGCTTTACT TTGTTAGCCA 60
TGTGTTTATG AACCCCCAGC GCTTTCCCTA GATCTTTTGG CTGATAATCT CAAACATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR032675--L_dom-like
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR013136--WSTF_Acf1_Cbp146
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS51136--WAC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00439--Bromodomain
PF02791--DDT
PF00628--PHD
PF10537--WAC_Acf1_DNA_bd
PF15612--WHIM1
PF15613--WSD

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD

Gene Ontology

GO:0016590--C:ACF complex
GO:0008623--C:CHRAC
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0006261--P:DNA-dependent DNA replication
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:11177

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002389	Ailuropoda melanoleuca	93.76	0.00e+00	1914.00
IUUC-Apl-004078	Anas platyrhynchos	73.46	0.00e+00	1984.00
IUUC-Aca-004951	Anolis carolinensis	72.37	0.00e+00	1405.00
IUUC-Bta-012850	Bos taurus	94.93	0.00e+00	1412.00
IUUC-Cel-018523	Caenorhabditis elegans	46.38	4.00e-16	81.30
IUUC-Cja-018999	Callithrix jacchus	94.73	0.00e+00	1925.00
IUUC-Cfa-020916	Canis familiaris	96.29	0.00e+00	1418.00
IUUC-Cpo-022146	Cavia porcellus	82.60	0.00e+00	2197.00
IUUC-Csa-024039	Chlorocebus sabaeus	97.95	0.00e+00	2634.00
IUUC-Cho-024914	Choloepus hoffmanni	83.61	0.00e+00	1322.00
IUUC-Cin-025450	Ciona intestinalis	42.92	6.00e-41	161.00
IUUC-Csv-026068	Ciona savignyi	54.55	5.00e-39	153.00
IUUC-Dre-027413	Danio rerio	57.93	0.00e+00	727.00
IUUC-Dno-029438	Dasypus novemcinctus	93.51	0.00e+00	1848.00
IUUC-Dor-030774	Dipodomys ordii	80.15	2.00e-163	570.00
IUUC-Dme-031772	Drosophila melanogaster	30.18	6.00e-35	144.00
IUUC-Ete-033052	Echinops telfairi	84.63	0.00e+00	1627.00
IUUC-Eca-034262	Equus caballus	94.02	0.00e+00	1835.00
IUUC-Eeu-034704	Erinaceus europaeus	72.56	0.00e+00	689.00
IUUC-Fca-036207	Felis catus	94.25	0.00e+00	926.00
IUUC-Fal-036702	Ficedula albicollis	74.76	0.00e+00	1658.00
IUUC-Gmo-039218	Gadus morhua	47.57	4.00e-93	337.00
IUUC-Gga-040776	Gallus gallus	77.96	0.00e+00	1428.00
IUUC-Gac-042358	Gasterosteus aculeatus	53.56	0.00e+00	703.00
IUUC-Itr-048135	Ictidomys tridecemlineatus	95.19	0.00e+00	1362.00
IUUC-Laf-054049	Loxodonta africana	92.91	0.00e+00	1915.00
IUUC-Mga-059382	Meleagris gallopavo	77.65	0.00e+00	1904.00
IUUC-Mmr-061301	Microcebus murinus	94.68	0.00e+00	1398.00
IUUC-Mdo-062889	Monodelphis domestica	81.19	0.00e+00	1569.00
IUUC-Mmu-064057	Mus musculus	87.16	0.00e+00	2273.00
IUUC-Mpu-066668	Mustela putorius furo	93.08	0.00e+00	1912.00
IUUC-Mlu-068089	Myotis lucifugus	95.17	0.00e+00	1382.00
IUUC-Nle-069936	Nomascus leucogenys	98.29	0.00e+00	2560.00
IUUC-Oan-073582	Ornithorhynchus anatinus	82.89	0.00e+00	1613.00
IUUC-Ocu-074115	Oryctolagus cuniculus	88.24	0.00e+00	2477.00
IUUC-Ogu-078790	Oryza glumaepatula	46.43	2.00e-13	70.10
IUUC-Ome-081195	Oryza meridionalis	50.98	2.00e-13	70.10
IUUC-Oru-084688	Oryza rufipogon	42.86	2.00e-13	70.50
IUUC-Ola-086709	Oryzias latipes	53.16	0.00e+00	949.00
IUUC-Oga-088100	Otolemur garnettii	90.47	0.00e+00	1301.00
IUUC-Oar-089208	Ovis aries	94.07	0.00e+00	1894.00
IUUC-Ptr-090630	Pan troglodytes	99.58	0.00e+00	2103.00
IUUC-Pan-092146	Papio anubis	95.27	0.00e+00	1438.00
IUUC-Psi-092932	Pelodiscus sinensis	77.71	0.00e+00	1475.00
IUUC-Pfo-096572	Poecilia formosa	55.39	0.00e+00	736.00
IUUC-Pva-102893	Pteropus vampyrus	95.25	0.00e+00	1939.00
IUUC-Rno-105098	Rattus norvegicus	86.95	0.00e+00	2204.00
IUUC-Sha-106513	Sarcophilus harrisii	80.58	0.00e+00	1567.00
IUUC-Sar-113192	Sorex araneus	98.47	3.00e-109	390.00
IUUC-Ssc-116407	Sus scrofa	95.76	0.00e+00	1375.00
IUUC-Tgu-117403	Taeniopygia guttata	76.90	0.00e+00	1963.00
IUUC-Tru-118124	Takifugu rubripes	54.08	0.00e+00	694.00
IUUC-Tsy-119386	Tarsius syrichta	92.72	0.00e+00	1389.00
IUUC-Vpa-130046	Vicugna pacos	91.50	0.00e+00	2255.00
IUUC-Xtr-132132	Xenopus tropicalis	61.50	0.00e+00	1091.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence