iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037907.16	ENSMUST00000145934.7	ENSMUSP00000119633.1
ENSMUSG00000037907.16	ENSMUST00000037593.13	ENSMUSP00000073584.6
ENSMUSG00000037907.16	ENSMUST00000127291.1	ENSMUSP00000118247.1
ENSMUSG00000037907.16	ENSMUST00000092892.9	ENSMUSP00000090568.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UIM	96.99	0.00e+00	1089.00	IUUC-Hsa-046090

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity).

Protein Sequence
(Fasta)

MIPANASARK GPEGKYPLHY LVWHNRHREL EKEVRAGQVD IEQLDPRGRT PLHLATTLGH 60
LECARVLLAH GADVGRENRS GWTVLQEAVS TRDLELVQLV LRYRDYQRVV KRLAGIPMLL 120

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Nucleotide Sequence
(Fasta)

ACATGCCCGA GCCGCAGCCC CGCGAGCAGA CAGCTCCGGC CGTCCGCCCC GCGGCCCCGG 60
GCCCGGGCTC CCGCGCCGTC CCTCCCCGCG GGCCGGGCGC CGCGGCCCCG GCATGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR021832--ANKRD13
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR003903--UIM_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM

Pfam

PF12796--Ank_2
PF11904--GPCR_chapero_1

SMART

SM00248--ANK
SM00726--UIM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005769--C:early endosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005886--C:plasma membrane

KEGG

mmu:268445

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000665	Aegilops tauschii	29.59	5.00e-14	72.40
IUUC-Aml-002227	Ailuropoda melanoleuca	96.92	0.00e+00	992.00
IUUC-Atr-002910	Amborella trichopoda	32.43	1.00e-30	128.00
IUUC-Aca-004536	Anolis carolinensis	74.15	0.00e+00	819.00
IUUC-Aly-006347	Arabidopsis lyrata	27.81	9.00e-34	138.00
IUUC-Ath-007312	Arabidopsis thaliana	27.96	5.00e-37	149.00
IUUC-Ame-011280	Astyanax mexicanus	70.66	0.00e+00	790.00
IUUC-Bta-012633	Bos taurus	95.64	0.00e+00	1093.00
IUUC-Bdi-015044	Brachypodium distachyon	33.21	4.00e-27	116.00
IUUC-Bol-016226	Brassica oleracea	28.06	1.00e-34	141.00
IUUC-Bra-017598	Brassica rapa	29.76	3.00e-38	153.00
IUUC-Cja-019421	Callithrix jacchus	96.10	0.00e+00	818.00
IUUC-Cfa-020114	Canis familiaris	94.64	0.00e+00	1069.00
IUUC-Cpo-022470	Cavia porcellus	96.59	0.00e+00	1030.00
IUUC-Csa-023354	Chlorocebus sabaeus	96.97	0.00e+00	1082.00
IUUC-Dre-027443	Danio rerio	69.72	0.00e+00	791.00
IUUC-Dno-029392	Dasypus novemcinctus	93.48	0.00e+00	957.00
IUUC-Dor-030806	Dipodomys ordii	91.46	0.00e+00	773.00
IUUC-Eca-033903	Equus caballus	96.36	0.00e+00	983.00
IUUC-Eeu-034577	Erinaceus europaeus	95.76	0.00e+00	878.00
IUUC-Fca-035836	Felis catus	94.64	0.00e+00	1078.00
IUUC-Fal-037542	Ficedula albicollis	84.34	0.00e+00	982.00
IUUC-Gmo-039247	Gadus morhua	68.35	0.00e+00	790.00
IUUC-Gga-040451	Gallus gallus	88.69	0.00e+00	969.00
IUUC-Gac-041465	Gasterosteus aculeatus	68.17	0.00e+00	771.00
IUUC-Gma-043893	Glycine max	32.40	8.00e-38	151.00
IUUC-Ggo-044843	Gorilla gorilla	96.95	0.00e+00	1005.00
IUUC-Hsa-046090	Homo sapiens	96.97	0.00e+00	1083.00
IUUC-Hvu-047841	Hordeum vulgare	31.43	1.00e-30	128.00
IUUC-Itr-048446	Ictidomys tridecemlineatus	96.92	0.00e+00	1048.00
IUUC-Lch-049984	Latimeria chalumnae	81.56	0.00e+00	855.00
IUUC-Lpe-051217	Leersia perrieri	33.33	5.00e-27	116.00
IUUC-Laf-054198	Loxodonta africana	91.26	0.00e+00	1031.00
IUUC-Mcc-055437	Macaca mulatta	97.14	0.00e+00	1082.00
IUUC-Meu-056403	Macropus eugenii	87.50	0.00e+00	925.00
IUUC-Mtr-058522	Medicago truncatula	28.37	1.00e-32	134.00
IUUC-Mga-059949	Meleagris gallopavo	84.14	0.00e+00	833.00
IUUC-Mmr-061704	Microcebus murinus	96.63	0.00e+00	1082.00
IUUC-Mdo-062800	Monodelphis domestica	89.39	0.00e+00	1031.00
IUUC-Mac-065460	Musa acuminata	29.58	2.00e-38	153.00
IUUC-Mpu-065892	Mustela putorius furo	95.91	0.00e+00	1004.00
IUUC-Mlu-067964	Myotis lucifugus	81.21	0.00e+00	808.00
IUUC-Nle-069652	Nomascus leucogenys	90.66	0.00e+00	890.00
IUUC-Opr-071009	Ochotona princeps	89.45	0.00e+00	887.00
IUUC-Ont-072518	Oreochromis niloticus	71.53	0.00e+00	764.00
IUUC-Oan-072815	Ornithorhynchus anatinus	85.94	0.00e+00	810.00
IUUC-Ocu-074278	Oryctolagus cuniculus	98.44	0.00e+00	919.00
IUUC-Oba-075972	Oryza barthii	30.17	5.00e-26	112.00
IUUC-Obr-076237	Oryza brachyantha	30.62	6.00e-26	112.00
IUUC-Ogl-077611	Oryza glaberrima	31.55	1.00e-31	131.00
IUUC-Ogu-078651	Oryza glumaepatula	31.55	1.00e-31	131.00
IUUC-Oin-079479	Oryza indica	31.55	1.00e-31	131.00
IUUC-Olo-080761	Oryza longistaminata	30.17	5.00e-26	112.00
IUUC-Ome-081427	Oryza meridionalis	31.55	2.00e-31	130.00
IUUC-Oni-082794	Oryza nivara	31.55	1.00e-31	131.00
IUUC-Opu-084158	Oryza punctata	31.23	4.00e-31	129.00
IUUC-Oru-084489	Oryza rufipogon	31.55	1.00e-31	131.00
IUUC-Osa-085430	Oryza sativa	31.55	1.00e-31	131.00
IUUC-Ola-087114	Oryzias latipes	69.03	0.00e+00	791.00
IUUC-Oga-089031	Otolemur garnettii	96.63	0.00e+00	1093.00
IUUC-Oar-089561	Ovis aries	92.64	0.00e+00	1047.00
IUUC-Ptr-091401	Pan troglodytes	96.80	0.00e+00	1075.00
IUUC-Pan-092615	Papio anubis	96.98	0.00e+00	1085.00
IUUC-Ppa-096001	Physcomitrella patens	34.36	1.00e-28	121.00
IUUC-Pfo-096300	Poecilia formosa	65.94	0.00e+00	763.00
IUUC-Pab-098006	Pongo abelii	96.40	0.00e+00	997.00
IUUC-Pop-099831	Populus trichocarpa	28.71	7.00e-32	132.00
IUUC-Pca-101055	Procavia capensis	91.12	0.00e+00	1032.00
IUUC-Ppe-101713	Prunus persica	34.70	5.00e-34	139.00
IUUC-Pva-102501	Pteropus vampyrus	98.21	0.00e+00	914.00
IUUC-Rno-104986	Rattus norvegicus	98.48	0.00e+00	1093.00
IUUC-Smo-109402	Selaginella moellendorffii	35.06	8.00e-34	138.00
IUUC-Sit-110746	Setaria italica	34.17	3.00e-28	120.00
IUUC-Sly-111817	Solanum lycopersicum	30.22	3.00e-35	143.00
IUUC-Stu-112735	Solanum tuberosum	34.10	2.00e-30	127.00
IUUC-Sar-113707	Sorex araneus	93.53	0.00e+00	994.00
IUUC-Sbi-114285	Sorghum bicolor	31.33	3.00e-31	130.00
IUUC-Ssc-116209	Sus scrofa	95.17	0.00e+00	1015.00
IUUC-Tgu-117342	Taeniopygia guttata	85.23	0.00e+00	912.00
IUUC-Tru-117882	Takifugu rubripes	64.15	0.00e+00	760.00
IUUC-Tni-119972	Tetraodon nigroviridis	66.18	0.00e+00	691.00
IUUC-Tca-121256	Theobroma cacao	33.73	6.00e-34	139.00
IUUC-Tae-123916	Triticum aestivum	37.04	4.00e-19	90.10
IUUC-Tur-126871	Triticum urartu	31.22	2.00e-24	107.00
IUUC-Tbe-127904	Tupaia belangeri	95.27	0.00e+00	779.00
IUUC-Ttr-128724	Tursiops truncatus	97.27	0.00e+00	1056.00
IUUC-Vvi-131403	Vitis vinifera	29.29	3.00e-30	127.00
IUUC-Xtr-132340	Xenopus tropicalis	74.11	0.00e+00	771.00
IUUC-Xma-133401	Xiphophorus maculatus	69.95	0.00e+00	752.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence