iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035905

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02069799

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000015062.3	ENSFCAT00000015066.3	ENSFCAP00000013971.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-127	425.3	396	731

Active Site

Position(s)	Description	Evidence
700	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 396  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 483
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt++Nk+eYv+l+v+
   Q: 484  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEDNKKEYVRLYVN 568
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++idv+d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 569  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDVSDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 656
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 657  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 731
           ******************************99999**************************************76 PP

Organism

Felis catus

Protein Sequence
(Fasta)

LINPFLCVSD FKFKLKHFSV LCAKNLAKKD FFRLPDPFAK IVVDGSGQCH STDTVKNTLD 60
PKWNQHYDLY VGKTDSITIS VWNHKKIHKK QGAGFLGCAR LLSNAISRLK DTGYQRLDLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGATAAATC CATTTCTGTG TGTTTCAGAT TTCAAGTTTA AATTAAAACA TTTTAGGGGT 60
GCCTGGGTGG CTCAGTTAAG TGGCCGACTC TGGCTCAGGT CATGATCTCA TGGCTCATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	93.27	0.00e+00	1428.00
IUUC-Apl-004155	Anas platyrhynchos	92.82	0.00e+00	1433.00
IUUC-Aca-005238	Anolis carolinensis	94.71	0.00e+00	1418.00
IUUC-Ame-010901	Astyanax mexicanus	89.38	0.00e+00	1351.00
IUUC-Bta-013221	Bos taurus	92.07	0.00e+00	1352.00
IUUC-Cja-018985	Callithrix jacchus	94.53	0.00e+00	1464.00
IUUC-Cfa-020568	Canis familiaris	95.95	0.00e+00	1451.00
IUUC-Cpo-022531	Cavia porcellus	94.00	0.00e+00	1455.00
IUUC-Csa-024145	Chlorocebus sabaeus	97.24	0.00e+00	1464.00
IUUC-Cho-024963	Choloepus hoffmanni	77.15	0.00e+00	922.00
IUUC-Cin-025126	Ciona intestinalis	62.70	0.00e+00	925.00
IUUC-Csv-026339	Ciona savignyi	62.73	0.00e+00	935.00
IUUC-Dre-028341	Danio rerio	89.67	0.00e+00	1359.00
IUUC-Dno-029705	Dasypus novemcinctus	93.87	0.00e+00	1428.00
IUUC-Dor-030314	Dipodomys ordii	98.63	2.00e-129	456.00
IUUC-Dme-031740	Drosophila melanogaster	72.02	2.00e-174	606.00
IUUC-Ete-032715	Echinops telfairi	69.71	0.00e+00	1045.00
IUUC-Eca-034125	Equus caballus	95.67	0.00e+00	1463.00
IUUC-Eeu-034945	Erinaceus europaeus	71.67	0.00e+00	1028.00
IUUC-Fal-037336	Ficedula albicollis	95.19	0.00e+00	1418.00
IUUC-Gmo-039486	Gadus morhua	80.49	0.00e+00	873.00
IUUC-Gga-040218	Gallus gallus	94.70	0.00e+00	1439.00
IUUC-Gac-041707	Gasterosteus aculeatus	83.20	0.00e+00	1248.00
IUUC-Ggo-045408	Gorilla gorilla	88.68	0.00e+00	1354.00
IUUC-Hsa-045878	Homo sapiens	94.40	0.00e+00	1462.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	95.26	0.00e+00	1456.00
IUUC-Lch-050026	Latimeria chalumnae	73.15	0.00e+00	1120.00
IUUC-Loc-052628	Lepisosteus oculatus	84.38	0.00e+00	1336.00
IUUC-Laf-053644	Loxodonta africana	92.73	0.00e+00	1397.00
IUUC-Mcc-055479	Macaca mulatta	89.50	0.00e+00	1316.00
IUUC-Mga-059723	Meleagris gallopavo	92.43	0.00e+00	1397.00
IUUC-Mmr-060806	Microcebus murinus	74.03	0.00e+00	1129.00
IUUC-Mdo-063005	Monodelphis domestica	95.49	0.00e+00	1459.00
IUUC-Mmu-063634	Mus musculus	96.96	0.00e+00	1441.00
IUUC-Mpu-065898	Mustela putorius furo	99.02	0.00e+00	1463.00
IUUC-Mlu-067584	Myotis lucifugus	95.01	0.00e+00	1455.00
IUUC-Nle-069033	Nomascus leucogenys	95.40	0.00e+00	1460.00
IUUC-Opr-070591	Ochotona princeps	70.01	0.00e+00	1042.00
IUUC-Ont-072265	Oreochromis niloticus	81.96	0.00e+00	1261.00
IUUC-Oan-073621	Ornithorhynchus anatinus	91.77	0.00e+00	1425.00
IUUC-Ocu-073960	Oryctolagus cuniculus	94.06	0.00e+00	1425.00
IUUC-Ola-086597	Oryzias latipes	72.96	0.00e+00	1129.00
IUUC-Oga-088579	Otolemur garnettii	94.40	0.00e+00	1461.00
IUUC-Oar-090396	Ovis aries	92.90	0.00e+00	1360.00
IUUC-Ptr-091624	Pan troglodytes	94.40	0.00e+00	1462.00
IUUC-Pan-092479	Papio anubis	94.27	0.00e+00	1461.00
IUUC-Psi-093298	Pelodiscus sinensis	74.17	0.00e+00	1129.00
IUUC-Pma-094354	Petromyzon marinus	67.60	0.00e+00	982.00
IUUC-Pfo-097203	Poecilia formosa	83.36	0.00e+00	1260.00
IUUC-Pab-097540	Pongo abelii	94.00	0.00e+00	1389.00
IUUC-Pca-100379	Procavia capensis	72.94	0.00e+00	645.00
IUUC-Pva-102754	Pteropus vampyrus	72.79	0.00e+00	1092.00
IUUC-Rno-105396	Rattus norvegicus	97.10	0.00e+00	1442.00
IUUC-Sha-107216	Sarcophilus harrisii	93.06	0.00e+00	1446.00
IUUC-Sar-113122	Sorex araneus	63.81	0.00e+00	925.00
IUUC-Ssc-116413	Sus scrofa	97.34	0.00e+00	1424.00
IUUC-Tgu-116723	Taeniopygia guttata	92.86	0.00e+00	1406.00
IUUC-Tru-117843	Takifugu rubripes	81.38	0.00e+00	1244.00
IUUC-Tsy-119455	Tarsius syrichta	93.96	0.00e+00	1361.00
IUUC-Tni-120829	Tetraodon nigroviridis	78.76	0.00e+00	1189.00
IUUC-Tbe-127879	Tupaia belangeri	81.59	0.00e+00	1196.00
IUUC-Ttr-128423	Tursiops truncatus	93.90	0.00e+00	1377.00
IUUC-Vpa-130591	Vicugna pacos	68.15	0.00e+00	1008.00
IUUC-Xtr-132237	Xenopus tropicalis	87.70	0.00e+00	1353.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence