iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040218

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000130

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000004655.5	ENSGALT00000007417.4	ENSGALP00000007405.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-128	428.3	406	741

Active Site

Position(s)	Description	Evidence
710	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 406  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 493
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 494  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYVN 578
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 579  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 666
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 667  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 741
           ******************************99999**************************************76 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAACC CCGGGACGCG TCGGAACGGC TCCAGCATCA AGATCCGCCT CACAGGTAAT 60
AACGGGGCGG GAGGGGCCCT CGCGCGGCCC GGGGCCCTCC TTCGCGCAGA GGGGCCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	90.17	0.00e+00	1389.00
IUUC-Apl-004155	Anas platyrhynchos	96.67	0.00e+00	1503.00
IUUC-Aca-005238	Anolis carolinensis	94.89	0.00e+00	1449.00
IUUC-Ame-010901	Astyanax mexicanus	90.70	0.00e+00	1392.00
IUUC-Bta-013221	Bos taurus	88.01	0.00e+00	1333.00
IUUC-Cja-018985	Callithrix jacchus	95.26	0.00e+00	1487.00
IUUC-Cfa-020568	Canis familiaris	93.12	0.00e+00	1434.00
IUUC-Cpo-022531	Cavia porcellus	94.60	0.00e+00	1477.00
IUUC-Csa-024145	Chlorocebus sabaeus	95.83	0.00e+00	1470.00
IUUC-Cho-024963	Choloepus hoffmanni	82.44	0.00e+00	757.00
IUUC-Cin-025126	Ciona intestinalis	62.89	0.00e+00	922.00
IUUC-Csv-026339	Ciona savignyi	62.25	0.00e+00	943.00
IUUC-Dre-028341	Danio rerio	90.71	0.00e+00	1402.00
IUUC-Dno-029705	Dasypus novemcinctus	93.49	0.00e+00	1424.00
IUUC-Dme-031740	Drosophila melanogaster	70.54	4.00e-176	612.00
IUUC-Eca-034125	Equus caballus	94.87	0.00e+00	1446.00
IUUC-Fca-035905	Felis catus	94.57	0.00e+00	1424.00
IUUC-Fal-037336	Ficedula albicollis	96.97	0.00e+00	1449.00
IUUC-Gmo-039486	Gadus morhua	79.74	0.00e+00	868.00
IUUC-Gac-041707	Gasterosteus aculeatus	84.63	0.00e+00	1292.00
IUUC-Ggo-045408	Gorilla gorilla	89.07	0.00e+00	1339.00
IUUC-Hsa-045878	Homo sapiens	95.13	0.00e+00	1485.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	94.73	0.00e+00	1440.00
IUUC-Loc-052628	Lepisosteus oculatus	85.34	0.00e+00	1377.00
IUUC-Laf-053644	Loxodonta africana	90.20	0.00e+00	1369.00
IUUC-Mcc-055479	Macaca mulatta	88.16	0.00e+00	1319.00
IUUC-Mga-059723	Meleagris gallopavo	93.99	0.00e+00	1432.00
IUUC-Mdo-063005	Monodelphis domestica	97.17	0.00e+00	1494.00
IUUC-Mmu-063634	Mus musculus	95.69	0.00e+00	1449.00
IUUC-Mpu-065898	Mustela putorius furo	95.21	0.00e+00	1429.00
IUUC-Mlu-067584	Myotis lucifugus	93.98	0.00e+00	1443.00
IUUC-Nle-069033	Nomascus leucogenys	95.01	0.00e+00	1449.00
IUUC-Ont-072265	Oreochromis niloticus	84.25	0.00e+00	1319.00
IUUC-Oan-073621	Ornithorhynchus anatinus	90.43	0.00e+00	1432.00
IUUC-Ocu-073960	Oryctolagus cuniculus	93.94	0.00e+00	1419.00
IUUC-Oga-088579	Otolemur garnettii	95.13	0.00e+00	1485.00
IUUC-Oar-090396	Ovis aries	91.81	0.00e+00	1350.00
IUUC-Ptr-091624	Pan troglodytes	95.13	0.00e+00	1485.00
IUUC-Pan-092479	Papio anubis	94.74	0.00e+00	1446.00
IUUC-Psi-094074	Pelodiscus sinensis	96.65	0.00e+00	1139.00
IUUC-Pfo-097203	Poecilia formosa	84.38	0.00e+00	1300.00
IUUC-Pab-097540	Pongo abelii	94.77	0.00e+00	1414.00
IUUC-Pca-100379	Procavia capensis	72.20	0.00e+00	634.00
IUUC-Rno-105396	Rattus norvegicus	95.69	0.00e+00	1451.00
IUUC-Sha-107216	Sarcophilus harrisii	95.09	0.00e+00	1474.00
IUUC-Ssc-116413	Sus scrofa	93.52	0.00e+00	1398.00
IUUC-Tgu-116723	Taeniopygia guttata	95.55	0.00e+00	1450.00
IUUC-Tru-117843	Takifugu rubripes	82.03	0.00e+00	1279.00
IUUC-Tsy-119455	Tarsius syrichta	94.35	0.00e+00	1353.00
IUUC-Tni-120037	Tetraodon nigroviridis	82.03	0.00e+00	1235.00
IUUC-Tbe-127879	Tupaia belangeri	80.81	0.00e+00	1177.00
IUUC-Ttr-128423	Tursiops truncatus	93.65	0.00e+00	1369.00
IUUC-Xtr-132237	Xenopus tropicalis	89.02	0.00e+00	1402.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence