iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073621

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01301399

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000007719.2	ENSOANT00000012298.1	ENSOANP00000012296.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-128	429.1	426	758

Active Site

Position(s)	Description	Evidence
727	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 426  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 513
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 514  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 598
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 599  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CTADSNIVKWFWQAVETFDEERRARLLQFV 686
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 687  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 758
           ***************************99999**************************************76 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

GRKRGEVQLK IAVLCAKNLA KKDFFRLPDP FAKIVVDGSG QCHSTDTVKN TLDPKWNQHY 60
DLYVGKTDSI TISVWNHKKI HKKQGAGFLG CVRLLSNAIS RLKDTGYQRL DLCKLNPTDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGAAAAA GAGGGGAAGT ACAGTTAATT TCTGAACCTC CGAAATGCTC TTCTGTGTGT 60
GTTCTTGAAG TCATCAGATA TATCTGAACT GTGAAAGTCC TGGTGGTGTC TTAATCGCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	92.18	0.00e+00	1427.00
IUUC-Apl-004155	Anas platyrhynchos	90.12	0.00e+00	1425.00
IUUC-Aca-005238	Anolis carolinensis	91.27	0.00e+00	1428.00
IUUC-Ame-010901	Astyanax mexicanus	85.56	0.00e+00	1347.00
IUUC-Bta-013221	Bos taurus	92.42	0.00e+00	1360.00
IUUC-Cja-018985	Callithrix jacchus	88.45	0.00e+00	1424.00
IUUC-Cfa-020568	Canis familiaris	88.20	0.00e+00	1401.00
IUUC-Cpo-022531	Cavia porcellus	87.94	0.00e+00	1416.00
IUUC-Csa-024145	Chlorocebus sabaeus	91.83	0.00e+00	1445.00
IUUC-Cho-024963	Choloepus hoffmanni	76.03	0.00e+00	750.00
IUUC-Dre-028341	Danio rerio	85.85	0.00e+00	1357.00
IUUC-Dno-029705	Dasypus novemcinctus	88.67	0.00e+00	1386.00
IUUC-Dme-031740	Drosophila melanogaster	70.85	1.00e-173	603.00
IUUC-Eca-034125	Equus caballus	89.32	0.00e+00	1414.00
IUUC-Fca-035905	Felis catus	91.63	0.00e+00	1410.00
IUUC-Fal-037336	Ficedula albicollis	92.41	0.00e+00	1417.00
IUUC-Gmo-039486	Gadus morhua	80.11	0.00e+00	868.00
IUUC-Gga-040218	Gallus gallus	90.43	0.00e+00	1432.00
IUUC-Gac-041707	Gasterosteus aculeatus	79.45	0.00e+00	1243.00
IUUC-Ggo-045408	Gorilla gorilla	84.17	0.00e+00	1312.00
IUUC-Hsa-045878	Homo sapiens	88.58	0.00e+00	1426.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	89.30	0.00e+00	1415.00
IUUC-Loc-052628	Lepisosteus oculatus	84.64	0.00e+00	1363.00
IUUC-Laf-053644	Loxodonta africana	92.38	0.00e+00	1394.00
IUUC-Mcc-055479	Macaca mulatta	83.60	0.00e+00	1278.00
IUUC-Mga-059723	Meleagris gallopavo	92.55	0.00e+00	1419.00
IUUC-Mdo-063005	Monodelphis domestica	92.51	0.00e+00	1453.00
IUUC-Mmu-063634	Mus musculus	90.81	0.00e+00	1407.00
IUUC-Mpu-065898	Mustela putorius furo	91.16	0.00e+00	1414.00
IUUC-Mlu-067584	Myotis lucifugus	89.19	0.00e+00	1412.00
IUUC-Nle-069033	Nomascus leucogenys	89.70	0.00e+00	1419.00
IUUC-Ont-072265	Oreochromis niloticus	78.26	0.00e+00	1257.00
IUUC-Ocu-073960	Oryctolagus cuniculus	88.06	0.00e+00	1382.00
IUUC-Oga-088579	Otolemur garnettii	88.58	0.00e+00	1425.00
IUUC-Oar-090396	Ovis aries	87.29	0.00e+00	1319.00
IUUC-Ptr-091624	Pan troglodytes	88.58	0.00e+00	1426.00
IUUC-Pan-092479	Papio anubis	89.58	0.00e+00	1419.00
IUUC-Pfo-097203	Poecilia formosa	80.05	0.00e+00	1271.00
IUUC-Pab-097540	Pongo abelii	87.95	0.00e+00	1354.00
IUUC-Pca-100379	Procavia capensis	72.08	0.00e+00	632.00
IUUC-Rno-105396	Rattus norvegicus	90.81	0.00e+00	1409.00
IUUC-Sha-107216	Sarcophilus harrisii	90.13	0.00e+00	1436.00
IUUC-Ssc-116413	Sus scrofa	90.55	0.00e+00	1387.00
IUUC-Tgu-116723	Taeniopygia guttata	88.96	0.00e+00	1393.00
IUUC-Tru-117843	Takifugu rubripes	80.76	0.00e+00	1272.00
IUUC-Tsy-119455	Tarsius syrichta	88.44	0.00e+00	1321.00
IUUC-Tni-120829	Tetraodon nigroviridis	79.55	0.00e+00	1205.00
IUUC-Tbe-127879	Tupaia belangeri	76.60	0.00e+00	1156.00
IUUC-Ttr-128423	Tursiops truncatus	87.89	0.00e+00	1335.00
IUUC-Xtr-132237	Xenopus tropicalis	82.95	0.00e+00	1343.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence