iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000017368.2	ENSPPYT00000033479.1	ENSPPYP00000024217.1
ENSPPYG00000017368.2	ENSPPYT00000020227.1	ENSPPYP00000019458.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-110	367.6	535	838

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 535  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 622
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 623  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 707
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 708  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 795
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnT 303
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++T
   Q: 796  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHT 838
           ******************************99999*******9 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

RRQRRKRRGR RASGSEVVEV VEVVEAAAAA AAARDWARLG GARVRAPQQA PISRLDHPPA 60
ARTPGPRSLC PGSDPGAQPG AVTLRRRRRR RRGRAGPGRG AAALDPRLPD RWREMSNPGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGGCAGC GGCGGAAGCG GCGAGGGCGG CGGGCGTCCG GCTCTGAGGT GGTGGAGGTG 60
GTGGAGGTGG TGGAGGCGGC GGCGGCGGCG GCGGCGGCAG CAGCAGCGGC GGCGGCAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	89.25	0.00e+00	1336.00
IUUC-Apl-004155	Anas platyrhynchos	93.10	0.00e+00	1384.00
IUUC-Aca-005238	Anolis carolinensis	92.16	0.00e+00	1360.00
IUUC-Ame-010901	Astyanax mexicanus	87.59	0.00e+00	1308.00
IUUC-Bta-013221	Bos taurus	87.34	0.00e+00	1274.00
IUUC-Cja-018985	Callithrix jacchus	99.45	0.00e+00	1504.00
IUUC-Cfa-020568	Canis familiaris	95.98	0.00e+00	1423.00
IUUC-Cpo-022531	Cavia porcellus	98.62	0.00e+00	1491.00
IUUC-Csa-024145	Chlorocebus sabaeus	95.72	0.00e+00	1425.00
IUUC-Cho-024963	Choloepus hoffmanni	88.39	0.00e+00	834.00
IUUC-Dre-028341	Danio rerio	88.29	0.00e+00	1321.00
IUUC-Dno-029705	Dasypus novemcinctus	97.21	0.00e+00	1430.00
IUUC-Dor-030314	Dipodomys ordii	98.17	4.00e-129	455.00
IUUC-Eca-034125	Equus caballus	98.73	0.00e+00	1457.00
IUUC-Fca-035905	Felis catus	94.00	0.00e+00	1373.00
IUUC-Fal-037336	Ficedula albicollis	92.82	0.00e+00	1337.00
IUUC-Gmo-039486	Gadus morhua	75.62	0.00e+00	790.00
IUUC-Gga-040218	Gallus gallus	94.77	0.00e+00	1414.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.69	0.00e+00	1207.00
IUUC-Ggo-045408	Gorilla gorilla	93.34	0.00e+00	1357.00
IUUC-Hsa-045878	Homo sapiens	99.86	0.00e+00	1509.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	97.88	0.00e+00	1437.00
IUUC-Loc-052628	Lepisosteus oculatus	82.71	0.00e+00	1296.00
IUUC-Laf-053644	Loxodonta africana	89.40	0.00e+00	1319.00
IUUC-Mcc-055479	Macaca mulatta	87.85	0.00e+00	1274.00
IUUC-Mga-059723	Meleagris gallopavo	89.22	0.00e+00	1320.00
IUUC-Mdo-063005	Monodelphis domestica	94.61	0.00e+00	1414.00
IUUC-Mmu-063634	Mus musculus	95.03	0.00e+00	1399.00
IUUC-Mpu-065898	Mustela putorius furo	94.51	0.00e+00	1376.00
IUUC-Mlu-067584	Myotis lucifugus	97.76	0.00e+00	1452.00
IUUC-Nle-069033	Nomascus leucogenys	99.86	0.00e+00	1473.00
IUUC-Ont-072265	Oreochromis niloticus	84.34	0.00e+00	1259.00
IUUC-Oan-073621	Ornithorhynchus anatinus	87.95	0.00e+00	1354.00
IUUC-Ocu-073960	Oryctolagus cuniculus	97.18	0.00e+00	1422.00
IUUC-Oga-088579	Otolemur garnettii	99.31	0.00e+00	1501.00
IUUC-Oar-090396	Ovis aries	95.21	0.00e+00	1336.00
IUUC-Ptr-091624	Pan troglodytes	99.86	0.00e+00	1509.00
IUUC-Pan-092479	Papio anubis	99.29	0.00e+00	1470.00
IUUC-Pfo-097203	Poecilia formosa	81.58	0.00e+00	1217.00
IUUC-Pca-100379	Procavia capensis	71.79	2.00e-167	582.00
IUUC-Rno-105396	Rattus norvegicus	95.17	0.00e+00	1401.00
IUUC-Sha-107216	Sarcophilus harrisii	94.58	0.00e+00	1407.00
IUUC-Sar-113250	Sorex araneus	96.58	0.00e+00	763.00
IUUC-Ssc-116413	Sus scrofa	92.38	0.00e+00	1343.00
IUUC-Tgu-116723	Taeniopygia guttata	93.37	0.00e+00	1352.00
IUUC-Tru-117843	Takifugu rubripes	79.65	0.00e+00	1202.00
IUUC-Tsy-119455	Tarsius syrichta	98.73	0.00e+00	1431.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.47	0.00e+00	1163.00
IUUC-Tbe-127879	Tupaia belangeri	84.11	0.00e+00	1184.00
IUUC-Ttr-128423	Tursiops truncatus	96.88	0.00e+00	1366.00
IUUC-Xtr-132237	Xenopus tropicalis	87.59	0.00e+00	1325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence