iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091624

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AC146030

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000019444.3	ENSPTRT00000035984.3	ENSPTRP00000047812.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-127	425.3	421	756

Active Site

Position(s)	Description	Evidence
725	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 421  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 508
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 509  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 593
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 594  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 681
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 682  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756
           ******************************99999**************************************76 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGGAG GCGGAGGCGG CGGCGGAGGC GGCGGCGGCG GCGGCTCGGG ACTGGGCTCG 60
GCTGGAAGCA GCGAGGGTCA GAGCGCCGCA GCAAGCGCCG ATCTCCCGGC TCGACCATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	89.83	0.00e+00	1406.00
IUUC-Apl-004155	Anas platyrhynchos	93.54	0.00e+00	1456.00
IUUC-Aca-005238	Anolis carolinensis	92.50	0.00e+00	1430.00
IUUC-Ame-010901	Astyanax mexicanus	87.99	0.00e+00	1378.00
IUUC-Bta-013221	Bos taurus	88.10	0.00e+00	1345.00
IUUC-Cja-018985	Callithrix jacchus	99.60	0.00e+00	1572.00
IUUC-Cfa-020568	Canis familiaris	96.29	0.00e+00	1494.00
IUUC-Cpo-022531	Cavia porcellus	98.68	0.00e+00	1558.00
IUUC-Csa-024145	Chlorocebus sabaeus	96.04	0.00e+00	1497.00
IUUC-Cho-024963	Choloepus hoffmanni	80.85	0.00e+00	982.00
IUUC-Dre-028341	Danio rerio	88.67	0.00e+00	1392.00
IUUC-Dno-029705	Dasypus novemcinctus	97.47	0.00e+00	1501.00
IUUC-Dme-031740	Drosophila melanogaster	71.11	2.00e-175	609.00
IUUC-Eca-034125	Equus caballus	98.92	0.00e+00	1524.00
IUUC-Fca-035905	Felis catus	94.40	0.00e+00	1446.00
IUUC-Fal-037336	Ficedula albicollis	93.27	0.00e+00	1408.00
IUUC-Gmo-039486	Gadus morhua	76.71	0.00e+00	858.00
IUUC-Gga-040218	Gallus gallus	95.13	0.00e+00	1485.00
IUUC-Gac-041707	Gasterosteus aculeatus	82.22	0.00e+00	1277.00
IUUC-Ggo-045408	Gorilla gorilla	93.78	0.00e+00	1428.00
IUUC-Hsa-045878	Homo sapiens	100.00	0.00e+00	1578.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	98.11	0.00e+00	1510.00
IUUC-Loc-052628	Lepisosteus oculatus	83.17	0.00e+00	1365.00
IUUC-Laf-053644	Loxodonta africana	89.99	0.00e+00	1389.00
IUUC-Mcc-055479	Macaca mulatta	88.51	0.00e+00	1348.00
IUUC-Mga-059723	Meleagris gallopavo	89.82	0.00e+00	1391.00
IUUC-Mdo-063005	Monodelphis domestica	94.98	0.00e+00	1486.00
IUUC-Mmu-063634	Mus musculus	95.24	0.00e+00	1469.00
IUUC-Mpu-065898	Mustela putorius furo	94.89	0.00e+00	1447.00
IUUC-Mlu-067584	Myotis lucifugus	97.72	0.00e+00	1519.00
IUUC-Nle-069033	Nomascus leucogenys	100.00	0.00e+00	1540.00
IUUC-Ont-072265	Oreochromis niloticus	84.89	0.00e+00	1330.00
IUUC-Oan-073621	Ornithorhynchus anatinus	88.58	0.00e+00	1426.00
IUUC-Ocu-073960	Oryctolagus cuniculus	97.44	0.00e+00	1494.00
IUUC-Oga-088579	Otolemur garnettii	99.47	0.00e+00	1568.00
IUUC-Oar-090396	Ovis aries	95.56	0.00e+00	1409.00
IUUC-Pan-092479	Papio anubis	99.73	0.00e+00	1539.00
IUUC-Pfo-097203	Poecilia formosa	82.25	0.00e+00	1288.00
IUUC-Pab-097540	Pongo abelii	99.86	0.00e+00	1504.00
IUUC-Pca-100379	Procavia capensis	73.81	0.00e+00	651.00
IUUC-Rno-105396	Rattus norvegicus	95.38	0.00e+00	1471.00
IUUC-Sha-107216	Sarcophilus harrisii	94.95	0.00e+00	1478.00
IUUC-Sar-113250	Sorex araneus	96.85	0.00e+00	833.00
IUUC-Ssc-116413	Sus scrofa	92.85	0.00e+00	1416.00
IUUC-Tgu-116723	Taeniopygia guttata	93.80	0.00e+00	1422.00
IUUC-Tru-117843	Takifugu rubripes	80.25	0.00e+00	1271.00
IUUC-Tsy-119455	Tarsius syrichta	98.87	0.00e+00	1434.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.88	0.00e+00	1230.00
IUUC-Tbe-127879	Tupaia belangeri	84.96	0.00e+00	1256.00
IUUC-Ttr-128423	Tursiops truncatus	97.15	0.00e+00	1440.00
IUUC-Xtr-132237	Xenopus tropicalis	88.13	0.00e+00	1392.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence