iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107216

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01076593

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000008364.1	ENSSHAT00000009749.1	ENSSHAP00000009664.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-128	427.1	420	755

Active Site

Position(s)	Description	Evidence
724	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 420  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 507
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 508  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 593  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 680
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 681  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 755
           ******************************99999**************************************76 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

FAKKITRRNV SFYFFSLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCAAAGA AAATAACAAG AAGAAATGTT TCTTTTTATT TTTTTTCTCT TACAGAAAAG 60
TAGAATAAAA GTCTTAATGA AATCTCTTTC ACAAGTGCTA ACTCTTTTTT TTTCTTATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	88.39	0.00e+00	1394.00
IUUC-Apl-004155	Anas platyrhynchos	95.70	0.00e+00	1464.00
IUUC-Aca-005238	Anolis carolinensis	93.54	0.00e+00	1433.00
IUUC-Ame-010901	Astyanax mexicanus	87.50	0.00e+00	1361.00
IUUC-Bta-013221	Bos taurus	88.60	0.00e+00	1333.00
IUUC-Cja-018985	Callithrix jacchus	94.81	0.00e+00	1477.00
IUUC-Cfa-020568	Canis familiaris	93.74	0.00e+00	1449.00
IUUC-Cpo-022531	Cavia porcellus	94.28	0.00e+00	1469.00
IUUC-Csa-024145	Chlorocebus sabaeus	93.75	0.00e+00	1452.00
IUUC-Cho-024963	Choloepus hoffmanni	76.76	0.00e+00	923.00
IUUC-Cin-025126	Ciona intestinalis	61.36	0.00e+00	915.00
IUUC-Csv-026339	Ciona savignyi	61.09	0.00e+00	929.00
IUUC-Dre-028341	Danio rerio	87.92	0.00e+00	1373.00
IUUC-Dno-029705	Dasypus novemcinctus	93.13	0.00e+00	1439.00
IUUC-Dme-031740	Drosophila melanogaster	71.11	1.00e-175	610.00
IUUC-Eca-034125	Equus caballus	95.26	0.00e+00	1464.00
IUUC-Fca-035905	Felis catus	92.92	0.00e+00	1431.00
IUUC-Fal-037336	Ficedula albicollis	93.31	0.00e+00	1424.00
IUUC-Gmo-039486	Gadus morhua	77.26	0.00e+00	858.00
IUUC-Gga-040218	Gallus gallus	95.09	0.00e+00	1474.00
IUUC-Gac-041707	Gasterosteus aculeatus	81.42	0.00e+00	1258.00
IUUC-Ggo-045408	Gorilla gorilla	88.93	0.00e+00	1360.00
IUUC-Hsa-045878	Homo sapiens	94.95	0.00e+00	1478.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	95.13	0.00e+00	1457.00
IUUC-Loc-052628	Lepisosteus oculatus	82.55	0.00e+00	1345.00
IUUC-Laf-053644	Loxodonta africana	88.82	0.00e+00	1375.00
IUUC-Mcc-055479	Macaca mulatta	86.17	0.00e+00	1302.00
IUUC-Mga-059723	Meleagris gallopavo	90.61	0.00e+00	1404.00
IUUC-Mdo-063005	Monodelphis domestica	95.74	0.00e+00	1485.00
IUUC-Mmu-063634	Mus musculus	93.35	0.00e+00	1432.00
IUUC-Mpu-065898	Mustela putorius furo	93.94	0.00e+00	1433.00
IUUC-Mlu-067584	Myotis lucifugus	94.49	0.00e+00	1458.00
IUUC-Nle-069033	Nomascus leucogenys	95.67	0.00e+00	1468.00
IUUC-Ont-072265	Oreochromis niloticus	83.18	0.00e+00	1289.00
IUUC-Oan-073621	Ornithorhynchus anatinus	90.13	0.00e+00	1436.00
IUUC-Ocu-073960	Oryctolagus cuniculus	93.93	0.00e+00	1430.00
IUUC-Oga-088579	Otolemur garnettii	94.95	0.00e+00	1477.00
IUUC-Oar-090396	Ovis aries	92.49	0.00e+00	1362.00
IUUC-Ptr-091624	Pan troglodytes	94.95	0.00e+00	1478.00
IUUC-Pan-092479	Papio anubis	94.67	0.00e+00	1467.00
IUUC-Psi-094074	Pelodiscus sinensis	95.02	0.00e+00	1141.00
IUUC-Pfo-097203	Poecilia formosa	81.45	0.00e+00	1266.00
IUUC-Pab-097540	Pongo abelii	94.58	0.00e+00	1407.00
IUUC-Pca-100379	Procavia capensis	72.73	0.00e+00	644.00
IUUC-Rno-105396	Rattus norvegicus	93.35	0.00e+00	1434.00
IUUC-Ssc-116413	Sus scrofa	93.00	0.00e+00	1399.00
IUUC-Tgu-116723	Taeniopygia guttata	93.60	0.00e+00	1428.00
IUUC-Tru-117843	Takifugu rubripes	79.20	0.00e+00	1244.00
IUUC-Tsy-119455	Tarsius syrichta	94.62	0.00e+00	1368.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.07	0.00e+00	1218.00
IUUC-Tbe-127879	Tupaia belangeri	81.30	0.00e+00	1192.00
IUUC-Ttr-128423	Tursiops truncatus	93.77	0.00e+00	1383.00
IUUC-Xtr-132237	Xenopus tropicalis	87.58	0.00e+00	1377.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence