iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116723

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01038134

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000007637.1	ENSTGUT00000007960.1	ENSTGUP00000007875.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-128	428.3	405	740

Active Site

Position(s)	Description	Evidence
709	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 405  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 492
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 493  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYVN 577
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 578  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 665
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 666  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 740
           ******************************99999**************************************76 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

VLCAKNLAKK DFFRLPDPFA KIVVDGSGQC HSTDTVKNTL DPKWNQHYDL YVGKTDSITI 60
SVWNHKKIHK KQGAGFLGCV RLLSNAISRL KDTGYQRLDL CKLNPTDTDA VRGQIVVSLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATTATGTG CCAAGAATCT CGCAAAGAAA GATTTCTTCA GTAAGTATGT CCTAATTGTG 60
TAGCTTTCTG CTCTGGATTA ATCAGATTTA TTTGGAGATG GTGCATTACT GTGGAGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	88.24	0.00e+00	1353.00
IUUC-Apl-004155	Anas platyrhynchos	95.56	0.00e+00	1430.00
IUUC-Aca-005238	Anolis carolinensis	92.60	0.00e+00	1385.00
IUUC-Ame-010901	Astyanax mexicanus	88.26	0.00e+00	1332.00
IUUC-Bta-013221	Bos taurus	86.86	0.00e+00	1300.00
IUUC-Cja-018985	Callithrix jacchus	93.40	0.00e+00	1404.00
IUUC-Cfa-020568	Canis familiaris	93.28	0.00e+00	1395.00
IUUC-Cpo-022531	Cavia porcellus	92.86	0.00e+00	1395.00
IUUC-Csa-024145	Chlorocebus sabaeus	92.72	0.00e+00	1385.00
IUUC-Cho-024963	Choloepus hoffmanni	75.32	0.00e+00	880.00
IUUC-Dre-028341	Danio rerio	87.85	0.00e+00	1326.00
IUUC-Dno-029705	Dasypus novemcinctus	92.99	0.00e+00	1389.00
IUUC-Dme-031740	Drosophila melanogaster	72.54	2.00e-175	609.00
IUUC-Eca-034125	Equus caballus	93.13	0.00e+00	1399.00
IUUC-Fca-035905	Felis catus	92.72	0.00e+00	1390.00
IUUC-Fal-037336	Ficedula albicollis	95.68	0.00e+00	1420.00
IUUC-Gmo-039486	Gadus morhua	76.76	0.00e+00	856.00
IUUC-Gga-040218	Gallus gallus	95.55	0.00e+00	1429.00
IUUC-Gac-041707	Gasterosteus aculeatus	82.33	0.00e+00	1229.00
IUUC-Ggo-045408	Gorilla gorilla	87.60	0.00e+00	1293.00
IUUC-Hsa-045878	Homo sapiens	93.53	0.00e+00	1404.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	93.67	0.00e+00	1399.00
IUUC-Loc-052628	Lepisosteus oculatus	83.19	0.00e+00	1316.00
IUUC-Laf-053644	Loxodonta africana	87.56	0.00e+00	1337.00
IUUC-Mcc-055479	Macaca mulatta	85.04	0.00e+00	1236.00
IUUC-Mga-059723	Meleagris gallopavo	91.36	0.00e+00	1383.00
IUUC-Mdo-063005	Monodelphis domestica	94.06	0.00e+00	1407.00
IUUC-Mmu-063634	Mus musculus	92.45	0.00e+00	1380.00
IUUC-Mpu-065898	Mustela putorius furo	92.86	0.00e+00	1393.00
IUUC-Mlu-067584	Myotis lucifugus	93.15	0.00e+00	1395.00
IUUC-Nle-069033	Nomascus leucogenys	93.53	0.00e+00	1403.00
IUUC-Ont-072265	Oreochromis niloticus	83.60	0.00e+00	1267.00
IUUC-Oan-073621	Ornithorhynchus anatinus	88.70	0.00e+00	1374.00
IUUC-Ocu-073960	Oryctolagus cuniculus	92.72	0.00e+00	1389.00
IUUC-Oga-088579	Otolemur garnettii	93.53	0.00e+00	1402.00
IUUC-Oar-090396	Ovis aries	91.78	0.00e+00	1334.00
IUUC-Ptr-091624	Pan troglodytes	93.53	0.00e+00	1404.00
IUUC-Pan-092479	Papio anubis	93.40	0.00e+00	1402.00
IUUC-Pfo-097203	Poecilia formosa	81.95	0.00e+00	1238.00
IUUC-Pab-097540	Pongo abelii	93.09	0.00e+00	1333.00
IUUC-Pca-100379	Procavia capensis	71.34	5.00e-177	614.00
IUUC-Rno-105396	Rattus norvegicus	92.45	0.00e+00	1383.00
IUUC-Sha-107216	Sarcophilus harrisii	93.33	0.00e+00	1410.00
IUUC-Ssc-116413	Sus scrofa	91.39	0.00e+00	1344.00
IUUC-Tru-117843	Takifugu rubripes	79.66	0.00e+00	1216.00
IUUC-Tsy-119455	Tarsius syrichta	92.81	0.00e+00	1325.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.04	0.00e+00	1192.00
IUUC-Tbe-127879	Tupaia belangeri	79.54	0.00e+00	1135.00
IUUC-Ttr-128423	Tursiops truncatus	92.31	0.00e+00	1343.00
IUUC-Xtr-132237	Xenopus tropicalis	88.53	0.00e+00	1340.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence