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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047016
UUCD1 version UUC-HoS-00575
Ensembl Protein ID ENSP00000373846.2
UniProt Accession O94822; A6NL41; A7E2D0; B2RTS0; C9J7U3; J3KPL4; Q05C47; Q9H8M4; Q9NUY5; Q9P0E9; LTN1_HUMAN
Genbank Protein ID BAA34434.2; CAB90429.3; CAB90430.1; AAH29371.1; AAI40791.1; AAI50285.1; BAA91976.1; BAB14589.1; AAF28910.1; ENSP00000354977
Protein Name E3 ubiquitin-protein ligase listerin; RING finger protein 160; RING-type E3 ubiquitin transferase listerin; Zinc finger protein 294
Genbank Nucleotide ID AB018257; AF129075; AL163249; BC029371; BC140790; BC150284; AK001915; AK023499; AF161350; DB452437
Gene Name LTN1; C21orf10; C21orf98; KIAA0714; RNF160; ZNF294; HSPC087
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198862.13 ENST00000389194.6 ENSP00000373846.2
ENSG00000198862.13 ENST00000389195.6 ENSP00000373847.2
ENSG00000198862.13 ENST00000483326.1 ENSP00000474690.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19196968
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0052 18.9 1761 1808
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf........kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +        k+  +   C+  fh  Cl+kw      ss++ +CPlCr
   Q: 1761 CMICFSVIhgfnyslpKK-AC-RTCKKKFHSACLYKW----FTSSNKSTCPLCR 1808
           99**99776655555444.44.45*************....99**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
 E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
Protein Sequence
(Fasta)
MDRVGGGKGP GGSYYRVSSS AARSRKLCPG RVNRGLSAQS TAATATMGGK NKQRTKGNLR 60
PSNSGRAAEL LAKEQGTVPG FIGFGTSQSD LGYVPAIQGA EEIDSLVDSD FRMVLRKLSK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047016|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGGGGCAG CAAATGGACA GGGTGGGTGG CGGAAAAGGG CCCGGGGGAA GTTATTACAG 60
GGTGTCCTCT TCCGCCGCCA GAAGCCGGAA GTTGTGTCCC GGACGTGTCA ACCGGGGTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047016|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00744--RINGv
Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0051865--P:protein autoubiquitination
KEGG hsa:26046
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000717 Aegilops tauschii 39.65 8.00e-48 186.00
IUUC-Aml-002311 Ailuropoda melanoleuca 91.51 0.00e+00 3076.00
IUUC-Atr-002905 Amborella trichopoda 40.95 1.00e-48 190.00
IUUC-Apl-003323 Anas platyrhynchos 67.40 0.00e+00 2158.00
IUUC-Aca-004616 Anolis carolinensis 65.11 0.00e+00 2152.00
IUUC-Aly-006145 Arabidopsis lyrata 40.30 2.00e-44 175.00
IUUC-Ath-006844 Arabidopsis thaliana 41.79 6.00e-47 184.00
IUUC-Ago-007750 Ashbya gossypii 32.33 7.00e-44 173.00
IUUC-Acl-008369 Aspergillus clavatus 29.24 8.00e-40 160.00
IUUC-Afl-008540 Aspergillus flavus 33.11 5.00e-40 160.00
IUUC-Afu-009089 Aspergillus fumigatus 29.32 1.00e-41 166.00
IUUC-Ani-009292 Aspergillus nidulans 31.44 1.00e-37 152.00
IUUC-Ang-009715 Aspergillus niger 29.52 3.00e-36 148.00
IUUC-Aor-009887 Aspergillus oryzae 33.11 4.00e-40 160.00
IUUC-Ate-010308 Aspergillus terreus 28.33 4.00e-30 128.00
IUUC-Ame-011345 Astyanax mexicanus 53.02 0.00e+00 1699.00
IUUC-Bgr-012196 Blumeria graminis 26.17 6.00e-18 87.40
IUUC-Bta-012535 Bos taurus 89.52 0.00e+00 3058.00
IUUC-Bci-013630 Botrytis cinerea 32.00 1.00e-40 163.00
IUUC-Bdi-014142 Brachypodium distachyon 41.70 3.00e-50 195.00
IUUC-Bol-015333 Brassica oleracea 40.49 4.00e-46 181.00
IUUC-Cel-018254 Caenorhabditis elegans 41.43 1.00e-44 175.00
IUUC-Cja-019469 Callithrix jacchus 95.40 0.00e+00 3321.00
IUUC-Cfa-020640 Canis familiaris 90.34 0.00e+00 3070.00
IUUC-Cpo-021322 Cavia porcellus 85.94 0.00e+00 2558.00
IUUC-Cre-022677 Chlamydomonas reinhardtii 37.22 5.00e-35 143.00
IUUC-Csa-024234 Chlorocebus sabaeus 97.62 0.00e+00 3257.00
IUUC-Cho-024709 Choloepus hoffmanni 79.91 0.00e+00 2052.00
IUUC-Csv-026100 Ciona savignyi 33.63 3.00e-66 248.00
IUUC-Cgl-026482 Colletotrichum gloeosporioides 25.44 4.00e-13 71.20
IUUC-Cne-026789 Cryptococcus neoformans 32.48 1.00e-36 149.00
IUUC-Cme-027135 Cyanidioschyzon merolae 33.78 3.00e-12 68.90
IUUC-Dre-027405 Danio rerio 52.13 0.00e+00 1657.00
IUUC-Dno-029874 Dasypus novemcinctus 87.72 0.00e+00 2407.00
IUUC-Dor-030589 Dipodomys ordii 92.29 0.00e+00 1362.00
IUUC-Dse-031427 Dothistroma septosporum 29.87 2.00e-39 159.00
IUUC-Dme-031827 Drosophila melanogaster 30.48 3.00e-70 261.00
IUUC-Ete-032459 Echinops telfairi 65.82 0.00e+00 1075.00
IUUC-Eca-033218 Equus caballus 91.63 0.00e+00 3094.00
IUUC-Eeu-035299 Erinaceus europaeus 75.25 0.00e+00 1945.00
IUUC-Fca-036081 Felis catus 90.93 0.00e+00 3072.00
IUUC-Fal-037561 Ficedula albicollis 66.72 0.00e+00 2160.00
IUUC-Fox-037930 Fusarium oxysporum 28.90 2.00e-38 155.00
IUUC-Fso-038413 Fusarium solani 25.53 6.00e-36 147.00
IUUC-Gmo-039359 Gadus morhua 48.78 0.00e+00 1559.00
IUUC-Ggr-039744 Gaeumannomyces graminis 30.13 6.00e-37 150.00
IUUC-Gga-041175 Gallus gallus 67.27 0.00e+00 2229.00
IUUC-Gac-041943 Gasterosteus aculeatus 49.00 0.00e+00 1566.00
IUUC-Gma-043888 Glycine max 40.10 6.00e-48 187.00
IUUC-Ggo-044912 Gorilla gorilla 98.80 0.00e+00 2094.00
IUUC-Hvu-047059 Hordeum vulgare 40.53 4.00e-49 191.00
IUUC-Itr-048789 Ictidomys tridecemlineatus 93.68 0.00e+00 1463.00
IUUC-Kpa-049133 Komagataella pastoris 30.92 2.00e-39 159.00
IUUC-Lch-049879 Latimeria chalumnae 53.02 0.00e+00 1561.00
IUUC-Lpe-051455 Leersia perrieri 42.58 1.00e-49 193.00
IUUC-Loc-052799 Lepisosteus oculatus 56.31 0.00e+00 1887.00
IUUC-Lma-052972 Leptosphaeria maculans 28.31 1.00e-37 153.00
IUUC-Laf-053479 Loxodonta africana 84.49 0.00e+00 2872.00
IUUC-Mcc-055120 Macaca mulatta 97.79 0.00e+00 3323.00
IUUC-Meu-055932 Macropus eugenii 72.55 0.00e+00 757.00
IUUC-Mor-057209 Magnaporthe oryzae 33.33 1.00e-40 162.00
IUUC-Mpo-057581 Magnaporthe poae 28.81 6.00e-33 137.00
IUUC-Mtr-058499 Medicago truncatula 41.55 4.00e-49 191.00
IUUC-Mla-059169 Melampsora laricipopulina 47.73 6.00e-37 145.00
IUUC-Mga-059800 Meleagris gallopavo 67.19 0.00e+00 2202.00
IUUC-Mvi-060350 Microbotryum violaceum 36.16 3.00e-53 204.00
IUUC-Mmr-061548 Microcebus murinus 92.25 0.00e+00 3202.00
IUUC-Mdo-062405 Monodelphis domestica 71.02 0.00e+00 2336.00
IUUC-Mmu-064389 Mus musculus 85.35 0.00e+00 2877.00
IUUC-Mac-064596 Musa acuminata 32.15 2.00e-50 196.00
IUUC-Mpu-065687 Mustela putorius furo 91.28 0.00e+00 3086.00
IUUC-Mlu-067591 Myotis lucifugus 84.16 0.00e+00 2802.00
IUUC-Nfi-068298 Neosartorya fischeri 28.95 3.00e-41 165.00
IUUC-Ncr-068876 Neurospora crassa 30.58 2.00e-40 162.00
IUUC-Nle-069799 Nomascus leucogenys 98.07 0.00e+00 3371.00
IUUC-Opr-071155 Ochotona princeps 74.36 0.00e+00 1212.00
IUUC-Ont-071290 Oreochromis niloticus 49.92 0.00e+00 1628.00
IUUC-Ocu-074947 Oryctolagus cuniculus 90.67 0.00e+00 3080.00
IUUC-Oba-075986 Oryza barthii 42.58 6.00e-50 194.00
IUUC-Obr-076304 Oryza brachyantha 43.63 2.00e-49 192.00
IUUC-Ogl-077600 Oryza glaberrima 42.58 6.00e-50 194.00
IUUC-Ogu-078079 Oryza glumaepatula 42.58 6.00e-50 194.00
IUUC-Oin-079935 Oryza indica 42.58 6.00e-50 193.00
IUUC-Olo-080897 Oryza longistaminata 42.58 7.00e-50 193.00
IUUC-Ome-081777 Oryza meridionalis 42.58 6.00e-50 193.00
IUUC-Oni-082298 Oryza nivara 42.58 5.00e-50 194.00
IUUC-Opu-083156 Oryza punctata 42.58 9.00e-50 193.00
IUUC-Oru-085243 Oryza rufipogon 42.58 5.00e-50 194.00
IUUC-Osa-086219 Oryza sativa 42.58 6.00e-50 194.00
IUUC-Ola-087202 Oryzias latipes 48.35 0.00e+00 1568.00
IUUC-Olu-087800 Ostreococcus lucimarinus 34.47 1.00e-42 169.00
IUUC-Oga-088962 Otolemur garnettii 92.35 0.00e+00 3277.00
IUUC-Oar-089858 Ovis aries 89.29 0.00e+00 3069.00
IUUC-Ptr-090958 Pan troglodytes 99.34 0.00e+00 3424.00
IUUC-Pan-092712 Papio anubis 97.61 0.00e+00 3389.00
IUUC-Psi-093557 Pelodiscus sinensis 68.63 0.00e+00 2365.00
IUUC-Pma-094131 Petromyzon marinus 55.68 2.00e-129 455.00
IUUC-Pno-094947 Phaeosphaeria nodorum 28.42 2.00e-37 152.00
IUUC-Ppa-095258 Physcomitrella patens 43.63 2.00e-52 201.00
IUUC-Pfo-097035 Poecilia formosa 49.33 0.00e+00 1548.00
IUUC-Pab-097897 Pongo abelii 98.41 0.00e+00 3193.00
IUUC-Pop-099487 Populus trichocarpa 40.48 2.00e-47 185.00
IUUC-Pca-100688 Procavia capensis 68.45 0.00e+00 1400.00
IUUC-Ppe-101821 Prunus persica 40.00 2.00e-48 188.00
IUUC-Pva-102632 Pteropus vampyrus 89.10 0.00e+00 2046.00
IUUC-Pgr-103311 Puccinia graminis 36.61 2.00e-51 199.00
IUUC-Ptt-103825 Puccinia triticina 34.42 2.00e-43 172.00
IUUC-Pte-104036 Pyrenophora teres 29.63 1.00e-37 152.00
IUUC-Pyt-104460 Pyrenophora triticirepentis 29.97 2.00e-38 155.00
IUUC-Rno-104852 Rattus norvegicus 85.50 0.00e+00 2973.00
IUUC-Sce-106305 Saccharomyces cerevisiae 31.86 6.00e-46 180.00
IUUC-Sja-107896 Schizosaccharomyces japonicus 39.23 2.00e-43 172.00
IUUC-Spo-108267 Schizosaccharomyces pombe 35.93 3.00e-45 178.00
IUUC-Smo-109180 Selaginella moellendorffii 27.33 9.00e-49 190.00
IUUC-Sit-110615 Setaria italica 39.32 4.00e-49 191.00
IUUC-Sly-111861 Solanum lycopersicum 41.90 9.00e-50 193.00
IUUC-Stu-112373 Solanum tuberosum 41.90 5.00e-50 193.00
IUUC-Sar-113666 Sorex araneus 81.80 0.00e+00 2232.00
IUUC-Sbi-114597 Sorghum bicolor 41.70 2.00e-50 196.00
IUUC-Sre-114965 Sporisorium reilianum 31.88 2.00e-45 178.00
IUUC-Ssc-115866 Sus scrofa 90.83 0.00e+00 3105.00
IUUC-Tgu-117521 Taeniopygia guttata 66.72 0.00e+00 2218.00
IUUC-Tru-117803 Takifugu rubripes 47.14 0.00e+00 1514.00
IUUC-Tsy-119135 Tarsius syrichta 88.64 0.00e+00 2377.00
IUUC-Tni-119807 Tetraodon nigroviridis 47.29 0.00e+00 1471.00
IUUC-Tca-121036 Theobroma cacao 40.95 9.00e-49 190.00
IUUC-Tre-121942 Trichoderma reesei 28.76 2.00e-37 152.00
IUUC-Tvi-122453 Trichoderma virens 27.67 7.00e-36 147.00
IUUC-Tae-123061 Triticum aestivum 39.65 9.00e-48 186.00
IUUC-Tur-126021 Triticum urartu 39.65 7.00e-48 187.00
IUUC-Tme-126889 Tuber melanosporum 33.25 3.00e-46 181.00
IUUC-Tbe-127297 Tupaia belangeri 80.92 0.00e+00 1249.00
IUUC-Ttr-128745 Tursiops truncatus 90.57 0.00e+00 3127.00
IUUC-Uma-129552 Ustilago maydis 32.54 5.00e-46 181.00
IUUC-Vda-129838 Verticillium dahliae 30.00 2.00e-39 159.00
IUUC-Vpa-130567 Vicugna pacos 89.23 0.00e+00 1601.00
IUUC-Vvi-131418 Vitis vinifera 41.43 4.00e-51 197.00
IUUC-Xtr-132926 Xenopus tropicalis 60.30 0.00e+00 2045.00
IUUC-Xma-134278 Xiphophorus maculatus 49.22 0.00e+00 1542.00
IUUC-Yli-134476 Yarrowia lipolytica 36.18 3.00e-49 191.00
IUUC-Zma-135611 Zea mays 41.26 7.00e-50 193.00
Created Date 25-Jun-2017

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