iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	HINT	InWeb_IM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-19	68.5	192	223

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlr 31
           gH+d+++++a+ sdt  vsGs+Dgt+ +W+++
   Q: 192  GHKDWIFAVAWlSDTVAVSGSRDGTVALWRMD 223
           8***********99***************975 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAQQQTGSRK RKAPAVEADA ESSPSQGLAA ADGEGPLLLK RQRRPATYRS MAHYLKVREV 60
GGWGPARLQG FDGELRGYAV QRLPELLTER QLELGTVNKV FASQWLNSRQ VVCGTKCNTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCGCCGCA CGCTGACTTT GCTCTCACTG CCCGGCCAGA CGCACTTCCC GCCTTCGCCT 60
AGGTCTGCAC CGCCACCGCC GCCCTCTCCC GCGCGTCCCT CACCCGGTCC GCCACTGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

KEGG

hsa:139170

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-024142	Chlorocebus sabaeus	95.03	0.00e+00	891.00
IUUC-Ggo-045082	Gorilla gorilla	97.78	0.00e+00	913.00
IUUC-Mcc-055164	Macaca mulatta	95.90	0.00e+00	922.00
IUUC-Nle-070092	Nomascus leucogenys	95.25	0.00e+00	918.00
IUUC-Pan-091736	Papio anubis	95.68	0.00e+00	919.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence