iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000205189.11	ENST00000379091.8	ENSP00000368384.4
ENSG00000205189.11	ENST00000430430.5	ENSP00000387462.1
ENSG00000205189.11	ENST00000426744.5	ENSP00000416134.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	8.90e-10	40.5	364	431

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv +vv g+ f+ahk +L a S++F+ l   ++ e+ +++++++++    + f+++l+FlY+g l +
   Q: 364  CDVSIVVSGKIFKAHKNILVAGSRFFKTLYcFSNKESPNQNNTTHLDIAAVQGFSVILDFLYSGNLVL 431
           8****************************95333333333666666668999************9976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP APPALQPPNG 60
RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA GGPTSLGGGA GGPLLAERNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATGACTA CTGTCCGGGG CCCGAGGTGC TGCCTCGCAC AATGCATCAA AGGAGGTTGT 60
GTCCGTGGTC GTAACCTCTT CGCGTGAAAG GCACCGCCTG GTCCAGTCTT TGTGAAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:65986

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002417	Ailuropoda melanoleuca	94.29	0.00e+00	1174.00
IUUC-Aca-004469	Anolis carolinensis	74.56	1.00e-125	442.00
IUUC-Ame-011346	Astyanax mexicanus	44.56	4.00e-111	395.00
IUUC-Bta-012861	Bos taurus	92.52	0.00e+00	1291.00
IUUC-Bci-013642	Botrytis cinerea	26.72	4.00e-06	45.40
IUUC-Cja-018896	Callithrix jacchus	96.85	0.00e+00	1250.00
IUUC-Cfa-020922	Canis familiaris	97.12	0.00e+00	1220.00
IUUC-Cpo-021973	Cavia porcellus	84.62	0.00e+00	1077.00
IUUC-Csa-023345	Chlorocebus sabaeus	97.37	0.00e+00	1412.00
IUUC-Dre-027561	Danio rerio	51.23	7.00e-108	384.00
IUUC-Dno-029805	Dasypus novemcinctus	91.41	0.00e+00	1212.00
IUUC-Dor-030754	Dipodomys ordii	83.09	0.00e+00	1150.00
IUUC-Ete-032796	Echinops telfairi	78.21	0.00e+00	1050.00
IUUC-Eca-033295	Equus caballus	94.91	0.00e+00	1038.00
IUUC-Eeu-034476	Erinaceus europaeus	85.79	0.00e+00	893.00
IUUC-Fca-036066	Felis catus	96.03	0.00e+00	1324.00
IUUC-Fal-036670	Ficedula albicollis	74.96	0.00e+00	914.00
IUUC-Gmo-039562	Gadus morhua	49.70	1.00e-119	423.00
IUUC-Gga-041244	Gallus gallus	74.26	9.00e-176	610.00
IUUC-Gac-041659	Gasterosteus aculeatus	51.53	3.00e-128	452.00
IUUC-Ggo-044525	Gorilla gorilla	97.01	0.00e+00	1351.00
IUUC-Itr-048557	Ictidomys tridecemlineatus	96.04	0.00e+00	863.00
IUUC-Loc-051835	Lepisosteus oculatus	40.83	3.00e-106	379.00
IUUC-Laf-053719	Loxodonta africana	86.97	0.00e+00	1233.00
IUUC-Mcc-055157	Macaca mulatta	97.14	0.00e+00	1409.00
IUUC-Meu-056336	Macropus eugenii	81.89	3.00e-151	529.00
IUUC-Mga-059399	Meleagris gallopavo	80.69	0.00e+00	832.00
IUUC-Mmr-061276	Microcebus murinus	93.01	0.00e+00	1345.00
IUUC-Mdo-062695	Monodelphis domestica	83.29	0.00e+00	1121.00
IUUC-Mmu-064205	Mus musculus	86.21	0.00e+00	1238.00
IUUC-Mpu-066671	Mustela putorius furo	94.97	0.00e+00	1347.00
IUUC-Mlu-067854	Myotis lucifugus	90.37	0.00e+00	1121.00
IUUC-Nle-069963	Nomascus leucogenys	98.50	0.00e+00	1391.00
IUUC-Ont-071653	Oreochromis niloticus	51.10	1.00e-160	560.00
IUUC-Oan-073626	Ornithorhynchus anatinus	73.52	4.00e-142	498.00
IUUC-Ocu-073862	Oryctolagus cuniculus	92.34	0.00e+00	1316.00
IUUC-Oga-088074	Otolemur garnettii	94.62	0.00e+00	1364.00
IUUC-Oar-089340	Ovis aries	89.45	0.00e+00	1339.00
IUUC-Ptr-090468	Pan troglodytes	99.77	0.00e+00	1414.00
IUUC-Psi-093295	Pelodiscus sinensis	76.95	0.00e+00	919.00
IUUC-Pfo-096654	Poecilia formosa	46.92	5.00e-150	525.00
IUUC-Pab-098683	Pongo abelii	95.53	0.00e+00	1330.00
IUUC-Pca-100679	Procavia capensis	88.60	0.00e+00	1224.00
IUUC-Pva-103039	Pteropus vampyrus	81.90	0.00e+00	822.00
IUUC-Rno-105993	Rattus norvegicus	85.61	0.00e+00	1122.00
IUUC-Sha-107020	Sarcophilus harrisii	83.72	0.00e+00	1111.00
IUUC-Ssl-108403	Sclerotinia sclerotiorum	30.61	9.00e-06	44.30
IUUC-Sar-113658	Sorex araneus	74.91	0.00e+00	788.00
IUUC-Ssc-115948	Sus scrofa	91.32	0.00e+00	1326.00
IUUC-Tgu-116753	Taeniopygia guttata	76.40	0.00e+00	927.00
IUUC-Tru-118354	Takifugu rubripes	61.11	4.00e-91	327.00
IUUC-Tsy-119124	Tarsius syrichta	88.75	0.00e+00	964.00
IUUC-Tni-119956	Tetraodon nigroviridis	47.16	9.00e-96	344.00
IUUC-Tbe-127314	Tupaia belangeri	86.20	0.00e+00	931.00
IUUC-Ttr-128408	Tursiops truncatus	91.77	0.00e+00	963.00
IUUC-Xtr-132456	Xenopus tropicalis	62.71	0.00e+00	766.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence