iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	miRecords
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19898466

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.50e-06	28.2	12	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..................................kdgplvlpCgHvfhadCl..qkw...pglknssskefrCPlCr 46
           C++C+e++                                  ++ ++vlpC H+f++ Cl  +++    g    +  + rCP+C+
   Q: 12   CLLCKEMCgspaplssnssasssssqtstssggggggpgaaaRR-LHVLPCLHAFCRPCLeaHRLpaaGGGAAGEPLKLRCPVCD 95
           99998888888888888777777777777777777777777444.***************5555599988888999999*****5 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.

Protein Sequence
(Fasta)

MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSGGGGGGPG AAARRLHVLP 60
CLHAFCRPCL EAHRLPAAGG GAAGEPLKLR CPVCDQKVVL AEAAGMDALP SSAFLLSNLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCTCTCCT CCTCCTCCTC CTCTTCCTCT CTGGTCTCCT CCCTCCTCCG GGCTGGGTTG 60
CAAATGGCTT CGTTCCCCGA GACCGATTTC CAGATCTGCT TGCTGTGCAA GGAGATGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box

SMART

SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0030371--F:translation repressor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0017148--P:negative regulation of translation
GO:0001843--P:neural tube closure
GO:0021915--P:neural tube development
GO:2000637--P:positive regulation of gene silencing by miRNA
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0072089--P:stem cell proliferation

KEGG

hsa:131405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001234	Ailuropoda melanoleuca	95.68	0.00e+00	1183.00
IUUC-Apl-003905	Anas platyrhynchos	93.66	0.00e+00	1150.00
IUUC-Aca-004326	Anolis carolinensis	85.88	0.00e+00	1213.00
IUUC-Ani-009171	Aspergillus nidulans	27.27	4.60e-02	32.70
IUUC-Ame-011573	Astyanax mexicanus	70.14	0.00e+00	1192.00
IUUC-Bta-013395	Bos taurus	96.48	0.00e+00	1316.00
IUUC-Cel-018188	Caenorhabditis elegans	35.95	2.00e-107	384.00
IUUC-Cja-019863	Callithrix jacchus	99.61	0.00e+00	1360.00
IUUC-Cfa-020285	Canis familiaris	92.98	0.00e+00	1435.00
IUUC-Cpo-021879	Cavia porcellus	93.90	0.00e+00	1487.00
IUUC-Csa-024271	Chlorocebus sabaeus	99.85	0.00e+00	1323.00
IUUC-Cho-024376	Choloepus hoffmanni	98.63	0.00e+00	1184.00
IUUC-Cin-025406	Ciona intestinalis	49.34	0.00e+00	640.00
IUUC-Cne-027010	Cryptococcus neoformans	26.00	2.00e-02	31.60
IUUC-Dno-029022	Dasypus novemcinctus	97.78	0.00e+00	1181.00
IUUC-Dor-031072	Dipodomys ordii	97.12	0.00e+00	1469.00
IUUC-Dme-031997	Drosophila melanogaster	48.18	2.00e-70	260.00
IUUC-Ete-032228	Echinops telfairi	98.25	0.00e+00	822.00
IUUC-Eca-033373	Equus caballus	99.22	0.00e+00	1056.00
IUUC-Eeu-034463	Erinaceus europaeus	96.82	0.00e+00	1138.00
IUUC-Fca-036184	Felis catus	95.83	0.00e+00	1190.00
IUUC-Fal-036918	Ficedula albicollis	83.43	0.00e+00	1170.00
IUUC-Fox-038003	Fusarium oxysporum	32.20	2.00e-03	36.20
IUUC-Gmo-039415	Gadus morhua	71.19	0.00e+00	885.00
IUUC-Gga-040379	Gallus gallus	90.67	0.00e+00	1264.00
IUUC-Gac-042330	Gasterosteus aculeatus	65.59	0.00e+00	1042.00
IUUC-Gma-043819	Glycine max	23.05	4.00e-12	67.40
IUUC-Ggo-045208	Gorilla gorilla	99.85	0.00e+00	1319.00
IUUC-Itr-048371	Ictidomys tridecemlineatus	98.46	0.00e+00	1196.00
IUUC-Kpa-049184	Komagataella pastoris	24.69	7.20e-02	30.80
IUUC-Lch-050324	Latimeria chalumnae	85.97	0.00e+00	1199.00
IUUC-Laf-054272	Loxodonta africana	94.63	0.00e+00	1259.00
IUUC-Mcc-055125	Macaca mulatta	99.08	0.00e+00	1473.00
IUUC-Meu-055934	Macropus eugenii	84.63	0.00e+00	1132.00
IUUC-Mga-059930	Meleagris gallopavo	93.33	0.00e+00	1144.00
IUUC-Mmr-060662	Microcebus murinus	97.33	0.00e+00	1312.00
IUUC-Mdo-062918	Monodelphis domestica	89.44	0.00e+00	1267.00
IUUC-Mmu-064351	Mus musculus	94.55	0.00e+00	1289.00
IUUC-Mpu-066325	Mustela putorius furo	98.25	0.00e+00	1051.00
IUUC-Mlu-067171	Myotis lucifugus	89.58	0.00e+00	1403.00
IUUC-Nle-069692	Nomascus leucogenys	99.85	0.00e+00	1323.00
IUUC-Opr-070354	Ochotona princeps	95.38	0.00e+00	1160.00
IUUC-Ont-072125	Oreochromis niloticus	75.70	0.00e+00	1088.00
IUUC-Oan-073079	Ornithorhynchus anatinus	95.21	0.00e+00	1161.00
IUUC-Ocu-073910	Oryctolagus cuniculus	94.94	0.00e+00	1299.00
IUUC-Ola-087162	Oryzias latipes	76.51	0.00e+00	1090.00
IUUC-Oga-088523	Otolemur garnettii	96.68	0.00e+00	1195.00
IUUC-Oar-090009	Ovis aries	98.26	0.00e+00	692.00
IUUC-Ptr-091173	Pan troglodytes	100.00	0.00e+00	1325.00
IUUC-Pan-091750	Papio anubis	99.70	0.00e+00	1317.00
IUUC-Psi-093053	Pelodiscus sinensis	89.06	0.00e+00	1085.00
IUUC-Pma-094227	Petromyzon marinus	58.99	1.00e-175	610.00
IUUC-Pfo-096980	Poecilia formosa	72.65	0.00e+00	1054.00
IUUC-Pab-098189	Pongo abelii	99.08	0.00e+00	1462.00
IUUC-Pva-103126	Pteropus vampyrus	95.70	0.00e+00	1297.00
IUUC-Rno-105653	Rattus norvegicus	96.02	0.00e+00	1301.00
IUUC-Sce-106389	Saccharomyces cerevisiae	25.64	5.50e-02	32.00
IUUC-Sha-107178	Sarcophilus harrisii	94.34	0.00e+00	1155.00
IUUC-Sar-113613	Sorex araneus	86.04	0.00e+00	983.00
IUUC-Tgu-116963	Taeniopygia guttata	92.99	0.00e+00	1143.00
IUUC-Tsy-119075	Tarsius syrichta	90.07	0.00e+00	1063.00
IUUC-Tni-120704	Tetraodon nigroviridis	81.40	0.00e+00	1011.00
IUUC-Tre-122209	Trichoderma reesei	25.84	1.30e-02	33.50
IUUC-Tbe-128141	Tupaia belangeri	78.23	0.00e+00	815.00
IUUC-Ttr-128908	Tursiops truncatus	93.43	0.00e+00	719.00
IUUC-Xtr-132272	Xenopus tropicalis	84.18	0.00e+00	1164.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence