iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000213588.5	ENST00000395064.2	ENSP00000378503.2
ENSG00000213588.5	ENST00000612407.1	ENSP00000478118.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.00e-10	41.6	48	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv l v+g+e +ahk+vLaa+S++F++ +l     ++  ++ ++   +++++f+ ll+ +Y+g+l++
   Q: 48   CDVSLLVQGRELRAHKAVLAAASPYFHDKLLL----GD-APRLTLPSvIEADAFEGLLQLIYSGRLRL 110
           8**************************98854....34.77888887799***************986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

METPTPLPPV PASPTCNPAP RTIQIEFPQH SSSLLESLNR HRLEGKFCDV SLLVQGRELR 60
AHKAVLAAAS PYFHDKLLLG DAPRLTLPSV IEADAFEGLL QLIYSGRLRL PLDALPAHLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATATCCAC ATTTATCTCT TTTAAAAATT ACCTAGAAAT AAGGTTTCTT TAATTGCTGG 60
TTAAAATGCT CCCGTGCAGA AAACAGGAAA GAACCTGCCT GGTTCCTTAG CAAATCTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:221504

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002425	Ailuropoda melanoleuca	87.55	0.00e+00	674.00
IUUC-Aca-004666	Anolis carolinensis	75.41	7.00e-49	187.00
IUUC-Bta-013390	Bos taurus	80.38	0.00e+00	630.00
IUUC-Cja-019872	Callithrix jacchus	94.12	0.00e+00	706.00
IUUC-Cpo-022310	Cavia porcellus	84.93	0.00e+00	664.00
IUUC-Csa-023132	Chlorocebus sabaeus	97.39	0.00e+00	730.00
IUUC-Dno-029908	Dasypus novemcinctus	86.12	1.00e-177	616.00
IUUC-Dor-030600	Dipodomys ordii	82.37	8.00e-104	369.00
IUUC-Eca-033275	Equus caballus	78.06	6.00e-174	603.00
IUUC-Fca-035621	Felis catus	85.68	0.00e+00	669.00
IUUC-Ggo-044991	Gorilla gorilla	98.91	0.00e+00	723.00
IUUC-Itr-048033	Ictidomys tridecemlineatus	88.48	0.00e+00	661.00
IUUC-Lch-049951	Latimeria chalumnae	43.33	5.00e-93	334.00
IUUC-Laf-053823	Loxodonta africana	80.80	7.00e-172	596.00
IUUC-Mcc-055867	Macaca mulatta	97.39	0.00e+00	730.00
IUUC-Meu-056796	Macropus eugenii	71.01	4.00e-139	488.00
IUUC-Mmr-060591	Microcebus murinus	88.03	0.00e+00	664.00
IUUC-Mdo-062238	Monodelphis domestica	71.61	6.00e-132	464.00
IUUC-Mmu-063383	Mus musculus	75.60	4.00e-162	564.00
IUUC-Mpu-066239	Mustela putorius furo	86.62	0.00e+00	687.00
IUUC-Nle-069789	Nomascus leucogenys	99.13	0.00e+00	724.00
IUUC-Opr-070294	Ochotona princeps	86.00	2.00e-172	598.00
IUUC-Ocu-074043	Oryctolagus cuniculus	84.39	1.00e-166	579.00
IUUC-Oga-088860	Otolemur garnettii	85.12	0.00e+00	648.00
IUUC-Oar-089355	Ovis aries	81.65	0.00e+00	649.00
IUUC-Ptr-090877	Pan troglodytes	99.56	0.00e+00	727.00
IUUC-Pan-092556	Papio anubis	97.17	0.00e+00	728.00
IUUC-Psi-093706	Pelodiscus sinensis	46.08	1.00e-48	187.00
IUUC-Pab-098419	Pongo abelii	98.73	0.00e+00	761.00
IUUC-Rno-105191	Rattus norvegicus	75.06	7.00e-139	487.00
IUUC-Ssc-116264	Sus scrofa	85.02	0.00e+00	704.00
IUUC-Tsy-119049	Tarsius syrichta	89.05	0.00e+00	657.00
IUUC-Ttr-129023	Tursiops truncatus	85.05	0.00e+00	664.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence