iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000215114.7	ENST00000399598.6	ENSP00000382507.2
ENSG00000215114.7	ENST00000520732.5	ENSP00000427759.1
ENSG00000215114.7	ENST00000523409.5	ENSP00000428314.1
ENSG00000215114.7	ENST00000521796.1	ENSP00000428241.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/UBX	4.30e-14	54.5	255	327

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/UBX

   S: 4    eqatlqiRlpdGkrlvrkFpssttleqiyqfve.yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsl 77
           +++++qiRl+dG+rl ++F+s++++ ++++f+   +  +    F Lv++fP+++l++e+   tl ea+++++  l
   Q: 255  PTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVqSRPEFAALDFILVTSFPNKELTDESL--TLLEADILNTVLL 327
           589******************************7788889999*****************..********99877 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.

Protein Sequence
(Fasta)

MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK ATVFKSPRTP 60
PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL NEATRASGDD KSKSFTGGGY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTCGGGTA GCGGGGACGC GCACGCACCT TGCGCGTCTT CGCCCCTCCT GCGGTTGCCA 60
GGCAACCGGC CCCGGAAGTT GCGGCAGGTG CGTCCGCAGC GGGCGCCGCT AGCCAGCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR012989--SEP_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS51399--SEP
PS50033--UBX

Pfam

PF08059--SEP
PF00789--UBX

SMART

SM00553--SEP
SM00166--UBX

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0043130--F:ubiquitin binding
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

hsa:137886

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001637	Ailuropoda melanoleuca	95.47	0.00e+00	640.00
IUUC-Apl-003738	Anas platyrhynchos	71.56	1.00e-121	429.00
IUUC-Aca-005097	Anolis carolinensis	72.67	5.00e-124	437.00
IUUC-Acl-008176	Aspergillus clavatus	39.66	3.00e-30	125.00
IUUC-Afl-008553	Aspergillus flavus	34.03	6.00e-25	108.00
IUUC-Aor-010016	Aspergillus oryzae	34.03	6.00e-25	108.00
IUUC-Bta-012629	Bos taurus	91.59	6.00e-160	556.00
IUUC-Cja-019732	Callithrix jacchus	85.50	9.00e-148	516.00
IUUC-Cfa-021132	Canis familiaris	95.47	0.00e+00	643.00
IUUC-Cpo-021389	Cavia porcellus	89.94	4.00e-168	583.00
IUUC-Csa-023362	Chlorocebus sabaeus	98.19	0.00e+00	640.00
IUUC-Cgl-026628	Colletotrichum gloeosporioides	32.78	8.00e-23	101.00
IUUC-Dno-029956	Dasypus novemcinctus	92.62	5.00e-169	587.00
IUUC-Dor-031124	Dipodomys ordii	83.12	1.00e-139	489.00
IUUC-Eca-034063	Equus caballus	92.45	0.00e+00	626.00
IUUC-Fca-035606	Felis catus	92.75	4.00e-180	623.00
IUUC-Fal-036923	Ficedula albicollis	72.89	9.00e-123	433.00
IUUC-Ggr-039971	Gaeumannomyces graminis	26.57	1.00e-14	74.30
IUUC-Gga-040906	Gallus gallus	71.12	4.00e-140	490.00
IUUC-Ggo-044801	Gorilla gorilla	100.00	0.00e+00	629.00
IUUC-Hvu-047203	Hordeum vulgare	31.89	2.00e-29	122.00
IUUC-Itr-047910	Ictidomys tridecemlineatus	94.27	6.00e-146	509.00
IUUC-Lpe-051122	Leersia perrieri	35.00	1.00e-32	134.00
IUUC-Lma-053319	Leptosphaeria maculans	33.83	1.00e-33	137.00
IUUC-Laf-053854	Loxodonta africana	89.56	8.00e-157	546.00
IUUC-Mcc-055607	Macaca mulatta	98.19	0.00e+00	627.00
IUUC-Mpo-057595	Magnaporthe poae	29.78	2.00e-19	90.10
IUUC-Mga-059714	Meleagris gallopavo	74.62	2.00e-132	465.00
IUUC-Mmr-061091	Microcebus murinus	96.10	6.00e-175	606.00
IUUC-Mdo-062985	Monodelphis domestica	79.45	1.00e-150	526.00
IUUC-Mmu-064382	Mus musculus	85.50	4.00e-157	547.00
IUUC-Mpu-066168	Mustela putorius furo	96.21	1.00e-180	625.00
IUUC-Mlu-067562	Myotis lucifugus	89.73	2.00e-166	578.00
IUUC-Nfi-068609	Neosartorya fischeri	37.99	2.00e-29	123.00
IUUC-Ncr-068786	Neurospora crassa	34.78	1.00e-24	107.00
IUUC-Nle-069639	Nomascus leucogenys	99.68	0.00e+00	626.00
IUUC-Oan-073007	Ornithorhynchus anatinus	84.87	6.00e-151	526.00
IUUC-Ocu-074507	Oryctolagus cuniculus	93.05	5.00e-176	610.00
IUUC-Oin-079640	Oryza indica	35.25	7.00e-34	138.00
IUUC-Olo-080962	Oryza longistaminata	34.80	2.00e-31	129.00
IUUC-Ome-081766	Oryza meridionalis	35.40	2.00e-31	131.00
IUUC-Opu-083365	Oryza punctata	34.53	4.00e-34	139.00
IUUC-Oga-088292	Otolemur garnettii	83.71	1.00e-147	516.00
IUUC-Oar-090236	Ovis aries	89.97	3.00e-155	540.00
IUUC-Ptr-090664	Pan troglodytes	100.00	0.00e+00	629.00
IUUC-Pan-092072	Papio anubis	98.36	5.00e-177	613.00
IUUC-Psi-093486	Pelodiscus sinensis	80.26	4.00e-133	467.00
IUUC-Pab-097813	Pongo abelii	100.00	0.00e+00	629.00
IUUC-Pca-100985	Procavia capensis	77.61	7.00e-108	383.00
IUUC-Ppe-101417	Prunus persica	34.30	1.00e-33	137.00
IUUC-Pva-102600	Pteropus vampyrus	93.83	1.00e-176	612.00
IUUC-Rno-105047	Rattus norvegicus	88.96	8.00e-162	562.00
IUUC-Sha-106777	Sarcophilus harrisii	83.13	6.00e-75	273.00
IUUC-Sbi-114513	Sorghum bicolor	33.82	2.00e-33	137.00
IUUC-Ssc-115936	Sus scrofa	93.53	8.00e-159	552.00
IUUC-Tgu-116752	Taeniopygia guttata	73.98	6.00e-129	453.00
IUUC-Tsy-119015	Tarsius syrichta	79.87	5.00e-140	490.00
IUUC-Ttr-128760	Tursiops truncatus	93.06	3.00e-165	574.00
IUUC-Vpa-130155	Vicugna pacos	92.41	1.00e-158	552.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence