iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-17	64.3	195	230

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           H++sv+ ++f   +t+l+s++dD  + vWD+ ++++
   Q: 195  HAGSVSTIHFnqRGTRLASSGDDLRVIVWDWVRQKP 230
           99********8655****************988775 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSHQEGSTGG LPDLVTESLF SSPEEQSGVA AVTAASSDIE MAATEPSTGD GGDTRDGGFL 60
NDASTENQNT DSESSSEDVE LESMGEGLFG YPLVGEETER EEEEEEMEEE GEEEEQPRMC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTACCTAC TGCCTTCTCC GACCGTCCGT CCTCGGGGCA GGCGTGCTCT CTTCCCTGAG 60
CTTTTAGGGG TTGGCTTTTC CAGTTCCAGA TCAGCTACAG CAAACATCGT TCGAGATGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

KEGG

hsa:139425

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019603	Callithrix jacchus	73.47	0.00e+00	769.00
IUUC-Ggo-045294	Gorilla gorilla	94.19	0.00e+00	1080.00
IUUC-Mcc-055417	Macaca mulatta	88.56	0.00e+00	984.00
IUUC-Nle-069431	Nomascus leucogenys	89.88	0.00e+00	966.00
IUUC-Pan-092353	Papio anubis	85.88	0.00e+00	983.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence