iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046230

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 17-like protein 5;Deubiquitinating enzyme 17-like protein 5;Ubiquitin thioesterase 17-like protein 5;Ubiquitin-specific-processing protease 17-like protein 5

Genbank Nucleotide ID

ENSP00000425955

Gene Name

USP17L5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000227140.3	ENST00000507227.1	ENSP00000425955.1

Annotation

Cancer Mutation
ICGC	COSMIC	CGAP
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	THPA	HPM
DNA & RNA Element
TRANSFAC	miRcode
Protein-protein Interaction
IID	HINT	InWeb_IM
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21239494

Classification

Family	E-value	Score	Start	End
DUB/USP	2.90e-80	271.7	81	374

Active Site

Position(s)	Description	Evidence
89	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
334	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           Gl+N+gNtCY+N+ LQcL+ +p+l++++l+ ++++++++     +kg++l+++q  ++  +++  ++++p++ l      a  f+  +q+Da
   Q: 81   GLQNMGNTCYVNASLQCLTYTPPLANYMLSrEHSQTCHR-----HKGCMLCTMQAHITRALHNPGHVIQPSQAL------AAGFHRGKQEDA 161
           9*****************************555555544.....689********9999999999999999755......456999****** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           +Efl+f +d++++++                  l+ +++ ++++k ++li+++F+g ++sqikcl+c+ +s +++p ld+ l+++  +    
   Q: 162  HEFLMFTVDAMKKAC------------------LPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQ---- 231
           ***************..................7888899************************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            s+q++Le+ +k+eel+gen+y+c  c ++  a+k+l+l++  +vLil LkRf  s      +ki k+v++p+ Ld++p++++p+++   + 
   Q: 232  -SVQQALEQLAKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRF--S--DVTGNKIAKNVQYPECLDMQPYMSQPNTG---PL 315
           .9***************************************************..3..35778********************9988...89 PP
   S: 277  kYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            Y L+av+vH G s+++GHY++yvk ++g+W+++dD +Vt+++ ++vl+   ++aYvlfY +
   Q: 316  VYVLYAVLVHAGwSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLS---QQAYVLFYIQ 374
           *************************************************...********86 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Protein Sequence
(Fasta)

MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR 60
QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY TPPLANYMLS REHSQTCHRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGACG ACTCACTCTA CTTGAGAGGT GAGTGGCAGT TCAACCACTT TTCAAAACTC 60
ACATCTTCTC GGCCCGATGC AGCTTTTGCT GAAATCCAGC GGACTTCTCT CCCTGAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006861--HABP4_PAIRBP1-bd
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF04774--HABP4_PAI-RBP1
PF00443--UCH

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006915--P:apoptotic process
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:728386

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence