iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046536

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 17-like protein 1; Deubiquitinating enzyme 17-like protein 1; Ubiquitin thioesterase 17-like protein 1; Ubiquitin-specific-processing protease 17-like protein 1

Genbank Nucleotide ID

AF228730

Gene Name

USP17L1; USP17L; USP17L1P

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000230549.3	ENST00000529559.1	ENSP00000485364.1

Annotation

Cancer Mutation
ICGC	CGAP
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	THPA	HPM
DNA & RNA Element
TRANSFAC	miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-72	246.0	81	374

Active Site

Position(s)	Description	Evidence
89	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10093}
334	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           Gl+N+gNtCY N+ LQcL+ + +l++++l+ +++++++      pk ++l+++q  ++  ++s  ++++p++       +a  f+  +q+D+
   Q: 81   GLQNMGNTCYENASLQCLTYTLPLANYMLSrEHSQTCQ-----RPKCCMLCTMQAHITWALHSPGHVIQPSQA------LAAGFHRGKQEDV 161
           9*****************************44444443.....5899*******9998887888888888865......4567999****** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           +Efl+f +d++++++                  l+ +++ +++ k ++li+++F+g ++sqikcl+c+ +s +++p ld+ l+++  +    
   Q: 162  HEFLMFTVDAMKKAC------------------LPGHKQVDHHCKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQ---- 231
           ***************..................78888999***********************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            s++++Le+ +k+eel+gen+y+c  c ++  a+ +l+l++  +vLil LkRf    +    +k+ k+v++p+ Ld++p++++++++   + 
   Q: 232  -SVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRF----SDVAGNKLAKNVQYPECLDMQPYMSQQNTG---PL 315
           .9***************************************************....335678********************8876...89 PP
   S: 277  kYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            Y L+av+vH G s++ GHY++yvk ++ +W+++dD +Vt+++  +vl+   ++aYvlfY +
   Q: 316  VYVLYAVLVHAGwSCHDGHYFSYVKAQEVQWYKMDDAEVTVCSIISVLS---QQAYVLFYIQ 374
           *************************************************...********86 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.

Protein Sequence
(Fasta)

MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR 60
QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TLPLANYMLS REHSQTCQRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGACG ACTCACTCTA CTTGGGAGGT GAGTGGCAGT TCAACCACTT TTCAAAACTC 60
ACATCTTCTC GGCCAGATGC AGCTTTTGCT GAAATCCAGC GGACTTCTCT CCCTGAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006915--P:apoptotic process
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:401447

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence