iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000241685.8	ENST00000441989.6	ENSP00000412879.1
ENSG00000241685.8	ENST00000262942.9	ENSP00000262942.5
ENSG00000241685.8	ENST00000432786.5	ENSP00000408711.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.10e-14	53.2	51	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           H++ +t++++ +  +++v+++ D + +vW+ ++gv
   Q: 51   HNGHITGIDWaPKsDRIVTCGADRNAYVWSQKDGV 85
           9999*******6669**************988776 PP

Organism

Homo sapiens

Functional Description
(View)

Belongs to the WD repeat ARPC1 family.

Protein Sequence
(Fasta)

MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW 60
APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTGGGCTT CCGTCCTCCG CCCGCGCCCG ACGGAGCCTG TTCGCGTCGA CTGCCCAGAG 60
TCCGCGAATC CTCCGCTCCG AGCCCGTCCG GACTCCCCCG ATCCCAGGTA ACGGCCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR030140--ARC1A
IPR017383--ARPC1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005885--C:Arp2/3 protein complex
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0003779--F:actin binding
GO:0051015--F:actin filament binding
GO:0030036--P:actin cytoskeleton organization
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0061024--P:membrane organization

KEGG

hsa:10552

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002044	Ailuropoda melanoleuca	100.00	0.00e+00	741.00
IUUC-Atr-002844	Amborella trichopoda	51.89	3.00e-55	208.00
IUUC-Apl-003325	Anas platyrhynchos	95.14	0.00e+00	743.00
IUUC-Aca-004736	Anolis carolinensis	95.14	0.00e+00	741.00
IUUC-Ago-007966	Ashbya gossypii	38.99	1.00e-65	243.00
IUUC-Acl-008334	Aspergillus clavatus	46.67	5.00e-92	331.00
IUUC-Afl-008485	Aspergillus flavus	46.52	6.00e-89	322.00
IUUC-Afu-008780	Aspergillus fumigatus	46.39	6.00e-93	334.00
IUUC-Ani-009417	Aspergillus nidulans	47.63	2.00e-93	335.00
IUUC-Ang-009543	Aspergillus niger	48.75	4.00e-95	341.00
IUUC-Aor-010234	Aspergillus oryzae	47.22	8.00e-91	327.00
IUUC-Ate-010386	Aspergillus terreus	47.63	2.00e-95	342.00
IUUC-Ame-011852	Astyanax mexicanus	91.08	0.00e+00	715.00
IUUC-Bgr-012192	Blumeria graminis	43.33	9.00e-84	303.00
IUUC-Bta-012530	Bos taurus	99.73	0.00e+00	739.00
IUUC-Bci-013616	Botrytis cinerea	44.44	1.00e-87	316.00
IUUC-Bdi-014632	Brachypodium distachyon	43.09	7.00e-78	284.00
IUUC-Cel-018122	Caenorhabditis elegans	56.71	5.00e-113	400.00
IUUC-Cja-019362	Callithrix jacchus	99.73	0.00e+00	741.00
IUUC-Cfa-020167	Canis familiaris	100.00	0.00e+00	741.00
IUUC-Cpo-021933	Cavia porcellus	100.00	0.00e+00	742.00
IUUC-Cho-024449	Choloepus hoffmanni	75.83	1.00e-98	353.00
IUUC-Cin-025186	Ciona intestinalis	56.49	7.00e-118	417.00
IUUC-Csv-026275	Ciona savignyi	56.32	1.00e-113	402.00
IUUC-Cgl-026732	Colletotrichum gloeosporioides	44.57	2.00e-88	318.00
IUUC-Cne-026926	Cryptococcus neoformans	45.91	8.00e-98	350.00
IUUC-Dre-028057	Danio rerio	90.54	0.00e+00	710.00
IUUC-Dno-029092	Dasypus novemcinctus	98.88	0.00e+00	709.00
IUUC-Dor-030391	Dipodomys ordii	98.88	0.00e+00	709.00
IUUC-Dse-031574	Dothistroma septosporum	44.66	4.00e-83	301.00
IUUC-Dme-031907	Drosophila melanogaster	58.47	2.00e-124	438.00
IUUC-Eca-034074	Equus caballus	100.00	0.00e+00	740.00
IUUC-Eeu-035041	Erinaceus europaeus	83.68	4.00e-94	338.00
IUUC-Fca-036154	Felis catus	100.00	0.00e+00	741.00
IUUC-Fal-037279	Ficedula albicollis	95.14	0.00e+00	742.00
IUUC-Fox-037842	Fusarium oxysporum	45.96	2.00e-88	319.00
IUUC-Fso-038276	Fusarium solani	45.68	3.00e-88	318.00
IUUC-Gmo-039673	Gadus morhua	87.57	0.00e+00	645.00
IUUC-Ggr-039762	Gaeumannomyces graminis	44.44	3.00e-87	315.00
IUUC-Gga-040189	Gallus gallus	95.95	0.00e+00	747.00
IUUC-Gac-042531	Gasterosteus aculeatus	88.38	0.00e+00	652.00
IUUC-Hvu-047456	Hordeum vulgare	29.78	6.00e-16	77.00
IUUC-Itr-047864	Ictidomys tridecemlineatus	100.00	0.00e+00	741.00
IUUC-Lch-050427	Latimeria chalumnae	89.76	0.00e+00	704.00
IUUC-Loc-052532	Lepisosteus oculatus	91.67	0.00e+00	689.00
IUUC-Lma-053109	Leptosphaeria maculans	45.30	8.00e-88	317.00
IUUC-Laf-054271	Loxodonta africana	99.73	0.00e+00	739.00
IUUC-Mcc-054857	Macaca mulatta	98.64	0.00e+00	717.00
IUUC-Meu-056540	Macropus eugenii	92.82	0.00e+00	626.00
IUUC-Mor-057167	Magnaporthe oryzae	42.78	3.00e-84	305.00
IUUC-Mla-058886	Melampsora laricipopulina	44.16	2.00e-90	326.00
IUUC-Mga-059327	Meleagris gallopavo	95.95	0.00e+00	747.00
IUUC-Mvi-060302	Microbotryum violaceum	46.41	3.00e-94	338.00
IUUC-Mmr-060765	Microcebus murinus	98.37	0.00e+00	719.00
IUUC-Mdo-062326	Monodelphis domestica	96.22	0.00e+00	723.00
IUUC-Mmu-063819	Mus musculus	98.65	0.00e+00	735.00
IUUC-Mac-064632	Musa acuminata	42.12	1.00e-80	293.00
IUUC-Mlu-067184	Myotis lucifugus	99.73	0.00e+00	738.00
IUUC-Nfi-068383	Neosartorya fischeri	46.67	5.00e-93	334.00
IUUC-Ncr-068777	Neurospora crassa	43.41	5.00e-87	314.00
IUUC-Nle-069900	Nomascus leucogenys	100.00	0.00e+00	741.00
IUUC-Opr-070386	Ochotona princeps	90.27	0.00e+00	650.00
IUUC-Ont-071283	Oreochromis niloticus	88.92	0.00e+00	655.00
IUUC-Oan-073139	Ornithorhynchus anatinus	95.95	0.00e+00	716.00
IUUC-Ocu-074340	Oryctolagus cuniculus	100.00	0.00e+00	741.00
IUUC-Opu-083392	Oryza punctata	33.52	8.00e-54	204.00
IUUC-Ola-087274	Oryzias latipes	87.33	0.00e+00	635.00
IUUC-Oga-088016	Otolemur garnettii	99.46	0.00e+00	738.00
IUUC-Oar-089613	Ovis aries	99.46	0.00e+00	738.00
IUUC-Ptr-091548	Pan troglodytes	100.00	0.00e+00	741.00
IUUC-Psi-093767	Pelodiscus sinensis	95.14	0.00e+00	741.00
IUUC-Pma-094124	Petromyzon marinus	78.59	3.00e-180	624.00
IUUC-Pno-095031	Phaeosphaeria nodorum	45.33	1.00e-87	317.00
IUUC-Ppa-095858	Physcomitrella patens	45.53	8.00e-86	310.00
IUUC-Pfo-097107	Poecilia formosa	88.38	0.00e+00	650.00
IUUC-Pop-098954	Populus trichocarpa	37.50	8.00e-43	167.00
IUUC-Pva-102908	Pteropus vampyrus	97.99	0.00e+00	652.00
IUUC-Pgr-103309	Puccinia graminis	44.64	7.00e-92	330.00
IUUC-Ptt-103959	Puccinia triticina	44.84	6.00e-94	337.00
IUUC-Pte-104384	Pyrenophora teres	46.24	3.00e-87	315.00
IUUC-Pyt-104686	Pyrenophora triticirepentis	46.24	6.00e-87	314.00
IUUC-Rno-105008	Rattus norvegicus	98.78	0.00e+00	647.00
IUUC-Sce-106411	Saccharomyces cerevisiae	37.20	2.00e-65	242.00
IUUC-Sha-106691	Sarcophilus harrisii	96.73	0.00e+00	719.00
IUUC-Sja-107792	Schizosaccharomyces japonicus	45.68	1.00e-87	316.00
IUUC-Spo-108053	Schizosaccharomyces pombe	44.77	8.00e-89	320.00
IUUC-Ssl-108606	Sclerotinia sclerotiorum	44.72	6.00e-88	317.00
IUUC-Smo-108836	Selaginella moellendorffii	46.28	6.00e-84	304.00
IUUC-Sit-110150	Setaria italica	42.39	3.00e-79	288.00
IUUC-Sar-113599	Sorex araneus	85.47	7.00e-172	596.00
IUUC-Sre-115090	Sporisorium reilianum	46.08	6.00e-97	347.00
IUUC-Ssc-115851	Sus scrofa	99.46	0.00e+00	738.00
IUUC-Tgu-116701	Taeniopygia guttata	95.14	0.00e+00	742.00
IUUC-Tru-117603	Takifugu rubripes	87.23	0.00e+00	657.00
IUUC-Tsy-119515	Tarsius syrichta	89.58	2.00e-74	273.00
IUUC-Tni-119844	Tetraodon nigroviridis	89.46	0.00e+00	651.00
IUUC-Tca-121645	Theobroma cacao	42.86	1.00e-79	290.00
IUUC-Tre-122045	Trichoderma reesei	44.85	2.00e-86	312.00
IUUC-Tvi-122523	Trichoderma virens	45.00	4.00e-87	314.00
IUUC-Tme-127018	Tuber melanosporum	44.93	9.00e-85	306.00
IUUC-Tbe-127321	Tupaia belangeri	99.69	0.00e+00	650.00
IUUC-Ttr-128178	Tursiops truncatus	99.14	0.00e+00	684.00
IUUC-Uma-129423	Ustilago maydis	45.81	2.00e-98	352.00
IUUC-Vda-129706	Verticillium dahliae	45.30	3.00e-88	318.00
IUUC-Xtr-132735	Xenopus tropicalis	84.64	0.00e+00	631.00
IUUC-Xma-133435	Xiphophorus maculatus	88.38	0.00e+00	650.00
IUUC-Yli-134471	Yarrowia lipolytica	46.07	6.00e-82	297.00
IUUC-Zma-135615	Zea mays	42.04	5.00e-80	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence