iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000243335.8	ENST00000275532.7	ENSP00000275532.3
ENSG00000243335.8	ENST00000503687.1	ENSP00000421074.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
PhosphositePlus	dbPTM	HPRD	Phospho.ELM
UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/A20	A20	17341663
UBD/ZnF/ZnF_A20	ZnF_A20	16499958; 22846990; 23048039; 26842620

Classification

Family	E-value	Score	Start	End
UBD/ZnF/ZnF_A20	9.60e-20	71.9	151	185

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           d+s+llCkkgCg+YGnp+++g+CSkC+ree++++r
   Q: 151  DQSDLLCKKGCGYYGNPAWQGFCSKCWREEYHKAR 185
           79*******************************86 PP

Organism

Homo sapiens

Functional Description
(View)

Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

Protein Sequence
(Fasta)

MVVVTGREPD SRRQDGAMSS SDAEDDFLEP ATPTATQAGH ALPLLPQERC AEFPALRGPP 60
TQGACSSCVQ RGPVLCHRAP PGAAGEHAAT EGREGAPSVS GTHALLQRPL GADCGDRPAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGGGCGC GAGCGGGTCG GCGTTGAGGG AGCCACCGCC CTCCCGCCTG CGCACTGCCT 60
CTCGCCCCCC TCCGGCCAGC CCGCAGCCGG CCGCGTCATG CCAGGCGCTG CTCGGCGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003123--VPS9
IPR002653--Znf_A20

PROSITE

PS51205--VPS9
PS51036--ZF_A20

Pfam

PF02204--VPS9
PF01754--zf-A20

SMART

SM00167--VPS9
SM00259--ZnF_A20

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031901--C:early endosome membrane
GO:0005730--C:nucleolus
GO:0055037--C:recycling endosome
GO:0003677--F:DNA binding
GO:0017137--F:Rab GTPase binding
GO:0017112--F:Rab guanyl-nucleotide exchange factor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0061024--P:membrane organization
GO:0050728--P:negative regulation of inflammatory response
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:1900235--P:negative regulation of Kit signaling pathway
GO:0002686--P:negative regulation of leukocyte migration
GO:0043305--P:negative regulation of mast cell degranulation
GO:0001933--P:negative regulation of protein phosphorylation
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0048261--P:negative regulation of receptor-mediated endocytosis
GO:0006612--P:protein targeting to membrane
GO:0060368--P:regulation of Fc receptor mediated stimulatory signaling pathway

KEGG

hsa:27342

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Fso-038087	Fusarium solani	34.00	2.40e-02	33.10
IUUC-Ggr-040104	Gaeumannomyces graminis	26.51	6.20e-02	32.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence