iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000258465.6	ENST00000556710.5	ENSP00000451235.1
ENSG00000258465.6	ENST00000485079.1	ENSP00000450870.1

Annotation

Cancer Mutation
ICGC	COSMIC	IntOGen
mRNA Expression
ArrayExpress	THPA
DNA & RNA Element
UTRdb	CircNet	TargetScan	RepTar
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	mUbiSiDa
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-21	76.9	345	376

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gHt+ v+ l+f   +t l+sGsdD ++ vWD+
   Q: 345  GHTGCVNTLHFnqRGTWLASGSDDLKVVVWDW 376
           8**********86559***************7 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MSEEELTKAM EGLGMDEGDG EGNILPIMQS IMQNLLSKDV LYPSLKEITE KYPEWLQSHR 60
ESLPPEQFEK YQEQHSVMCK ICEQFEAETP TDSETTQKAR FEMVLDLMQQ LQDLGHPPKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAAGATGG CCGCCGCTGA GGAAGGCTGT AGTGTCGGGG CCGAAGCGGA CAGGGAATTG 60
GAGGAGCTTC TGGAAAGTAA GAGCCCATAG TGGGAAAGGC CCGAAGAGGG CACGTGTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0488--Methylation
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016567--P:protein ubiquitination

KEGG

hsa:50717

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000985	Aegilops tauschii	40.93	3.00e-83	302.00
IUUC-Aml-001810	Ailuropoda melanoleuca	95.87	0.00e+00	1287.00
IUUC-Atr-002578	Amborella trichopoda	43.37	6.00e-82	298.00
IUUC-Apl-003872	Anas platyrhynchos	66.88	3.00e-159	554.00
IUUC-Aca-004853	Anolis carolinensis	79.84	0.00e+00	1102.00
IUUC-Aly-005505	Arabidopsis lyrata	41.04	3.00e-79	289.00
IUUC-Ath-007629	Arabidopsis thaliana	41.55	2.00e-77	283.00
IUUC-Ame-011615	Astyanax mexicanus	62.83	0.00e+00	694.00
IUUC-Bta-013549	Bos taurus	97.82	0.00e+00	1082.00
IUUC-Bdi-014538	Brachypodium distachyon	40.46	1.00e-74	273.00
IUUC-Cja-018802	Callithrix jacchus	98.99	0.00e+00	1085.00
IUUC-Cfa-020535	Canis familiaris	98.49	0.00e+00	1078.00
IUUC-Cpo-022216	Cavia porcellus	96.31	0.00e+00	1075.00
IUUC-Csa-023095	Chlorocebus sabaeus	99.50	0.00e+00	1090.00
IUUC-Cin-025683	Ciona intestinalis	57.72	7.00e-144	503.00
IUUC-Csv-026331	Ciona savignyi	57.52	1.00e-125	443.00
IUUC-Dre-027731	Danio rerio	63.70	0.00e+00	675.00
IUUC-Dno-029192	Dasypus novemcinctus	96.31	0.00e+00	1045.00
IUUC-Dse-031250	Dothistroma septosporum	49.43	1.00e-23	105.00
IUUC-Dme-032115	Drosophila melanogaster	42.66	3.00e-83	303.00
IUUC-Ete-032932	Echinops telfairi	88.10	0.00e+00	894.00
IUUC-Eca-034100	Equus caballus	98.83	0.00e+00	1083.00
IUUC-Fca-036138	Felis catus	97.65	0.00e+00	1075.00
IUUC-Fal-037132	Ficedula albicollis	96.46	2.00e-55	206.00
IUUC-Gmo-038895	Gadus morhua	77.89	0.00e+00	631.00
IUUC-Gga-040447	Gallus gallus	88.46	0.00e+00	934.00
IUUC-Gac-041796	Gasterosteus aculeatus	77.51	0.00e+00	674.00
IUUC-Gma-044062	Glycine max	40.41	2.00e-74	273.00
IUUC-Ggo-045613	Gorilla gorilla	100.00	0.00e+00	1065.00
IUUC-Hvu-047687	Hordeum vulgare	42.74	5.00e-85	308.00
IUUC-Itr-048599	Ictidomys tridecemlineatus	91.62	0.00e+00	969.00
IUUC-Lch-050050	Latimeria chalumnae	67.08	0.00e+00	637.00
IUUC-Lpe-051191	Leersia perrieri	41.85	5.00e-81	295.00
IUUC-Laf-053407	Loxodonta africana	96.98	0.00e+00	1022.00
IUUC-Mcc-055604	Macaca mulatta	95.47	0.00e+00	1291.00
IUUC-Meu-056043	Macropus eugenii	90.19	0.00e+00	857.00
IUUC-Mtr-057813	Medicago truncatula	40.89	3.00e-81	295.00
IUUC-Mga-059697	Meleagris gallopavo	88.10	3.00e-171	594.00
IUUC-Mmr-061338	Microcebus murinus	97.35	0.00e+00	1342.00
IUUC-Mdo-062689	Monodelphis domestica	97.12	0.00e+00	986.00
IUUC-Mmu-063993	Mus musculus	95.48	0.00e+00	1055.00
IUUC-Mac-064558	Musa acuminata	40.30	5.00e-82	298.00
IUUC-Mpu-066622	Mustela putorius furo	97.32	0.00e+00	1073.00
IUUC-Mlu-067235	Myotis lucifugus	94.66	0.00e+00	1261.00
IUUC-Nle-069048	Nomascus leucogenys	99.50	0.00e+00	1090.00
IUUC-Opr-070489	Ochotona princeps	80.06	2.00e-140	492.00
IUUC-Ont-072060	Oreochromis niloticus	77.16	0.00e+00	687.00
IUUC-Ocu-074684	Oryctolagus cuniculus	97.99	0.00e+00	1043.00
IUUC-Oba-075746	Oryza barthii	41.39	6.00e-84	305.00
IUUC-Obr-076629	Oryza brachyantha	41.96	6.00e-86	311.00
IUUC-Ogl-077243	Oryza glaberrima	43.12	1.00e-85	310.00
IUUC-Ogu-078029	Oryza glumaepatula	43.12	1.00e-85	310.00
IUUC-Oin-080109	Oryza indica	39.09	2.00e-73	269.00
IUUC-Olo-080308	Oryza longistaminata	41.97	5.00e-83	301.00
IUUC-Ome-081126	Oryza meridionalis	43.05	4.00e-83	301.00
IUUC-Oni-083114	Oryza nivara	43.12	6.00e-86	311.00
IUUC-Opu-083288	Oryza punctata	42.25	3.00e-83	302.00
IUUC-Oru-084724	Oryza rufipogon	43.12	1.00e-85	310.00
IUUC-Osa-085895	Oryza sativa	43.12	1.00e-85	310.00
IUUC-Olu-087847	Ostreococcus lucimarinus	29.86	4.00e-35	142.00
IUUC-Oga-088849	Otolemur garnettii	98.83	0.00e+00	1084.00
IUUC-Oar-089474	Ovis aries	94.97	0.00e+00	1028.00
IUUC-Ptr-091235	Pan troglodytes	100.00	0.00e+00	1097.00
IUUC-Pan-092895	Papio anubis	99.50	0.00e+00	1090.00
IUUC-Psi-093973	Pelodiscus sinensis	87.17	0.00e+00	1148.00
IUUC-Ppa-095764	Physcomitrella patens	42.20	6.00e-85	308.00
IUUC-Pfo-097275	Poecilia formosa	77.83	0.00e+00	687.00
IUUC-Pab-098299	Pongo abelii	97.44	0.00e+00	1115.00
IUUC-Pop-099784	Populus trichocarpa	41.94	3.00e-79	288.00
IUUC-Pca-100729	Procavia capensis	93.63	0.00e+00	1002.00
IUUC-Ppe-101712	Prunus persica	40.47	4.00e-79	288.00
IUUC-Pva-103030	Pteropus vampyrus	98.99	0.00e+00	1085.00
IUUC-Rno-105416	Rattus norvegicus	96.98	0.00e+00	1070.00
IUUC-Sha-106545	Sarcophilus harrisii	94.58	0.00e+00	1217.00
IUUC-Smo-109128	Selaginella moellendorffii	46.37	1.00e-90	326.00
IUUC-Sit-110823	Setaria italica	40.92	2.00e-84	306.00
IUUC-Sly-111605	Solanum lycopersicum	38.61	1.00e-75	277.00
IUUC-Stu-111978	Solanum tuberosum	40.65	3.00e-81	295.00
IUUC-Sbi-114455	Sorghum bicolor	41.01	2.00e-79	289.00
IUUC-Ssc-115612	Sus scrofa	98.49	0.00e+00	1079.00
IUUC-Tru-117708	Takifugu rubripes	77.40	0.00e+00	690.00
IUUC-Tsy-119579	Tarsius syrichta	89.20	0.00e+00	743.00
IUUC-Tni-120739	Tetraodon nigroviridis	70.19	0.00e+00	696.00
IUUC-Tca-121555	Theobroma cacao	42.03	9.00e-80	291.00
IUUC-Tae-125509	Triticum aestivum	44.23	2.00e-86	313.00
IUUC-Tur-126617	Triticum urartu	41.53	3.00e-73	269.00
IUUC-Tbe-128115	Tupaia belangeri	95.42	0.00e+00	714.00
IUUC-Ttr-128231	Tursiops truncatus	93.47	0.00e+00	1004.00
IUUC-Vpa-130377	Vicugna pacos	81.24	0.00e+00	870.00
IUUC-Vvi-131540	Vitis vinifera	41.36	3.00e-79	289.00
IUUC-Xtr-131860	Xenopus tropicalis	77.78	0.00e+00	826.00
IUUC-Xma-133371	Xiphophorus maculatus	77.64	0.00e+00	688.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence