iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	mUbiSiDa
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19690564

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.80e-11	45.6	37	106
E3 activity/RING/RING	8.30e-14	53.5	43	88

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl......asggktcPvtrqplteedlvPnltlrrli 65
           + ee  CpI lel ++P  + +G+++ +++I          ++g+++cPv++++ ++ +l Pn  l +++
   Q: 37   IREEVTCPICLELLTEPLSIDCGHSFCQACITPNGresvigQEGERSCPVCQTSYQPGNLRPNRHLANIV 106
           678999*************************874433334666666*****************9987765 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.....qkwpglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+     + +      + +e +CP+C+
   Q: 43   CPICLELLTE-PLSIDCGHSFCQACItpngrESV----IGQEGERSCPVCQ 88
           ********99.***************87655555....999*********7 PP

Organism

Homo sapiens

Functional Description
(View)

May function as antiviral protein and may contribute to the defense against retroviral infections.

Protein Sequence
(Fasta)

MCGSERILQA GNILEIRVGQ AGARRVATMT SPVLVDIREE VTCPICLELL TEPLSIDCGH 60
SFCQACITPN GRESVIGQEG ERSCPVCQTS YQPGNLRPNR HLANIVRRLR EVVLGPGKQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCCTTTCT CGGAACGGAA CGGAGCAGAG TCGTGCGTGG TTGAGTTTAG ATAAAAGCCG 60
AGTGAGCGCG CTCTGTTCCT TAAGATTAGT TTAAGGTGCC TTGGATTGCT CTGAAGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206--P:protein trimerization

KEGG

hsa:53840

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001740	Ailuropoda melanoleuca	74.03	0.00e+00	653.00
IUUC-Bta-013071	Bos taurus	73.60	0.00e+00	1144.00
IUUC-Cja-018923	Callithrix jacchus	80.53	0.00e+00	1159.00
IUUC-Cfa-021152	Canis familiaris	73.51	0.00e+00	1156.00
IUUC-Cpo-021369	Cavia porcellus	66.26	2.00e-164	572.00
IUUC-Csa-023747	Chlorocebus sabaeus	94.67	0.00e+00	1170.00
IUUC-Dno-029492	Dasypus novemcinctus	62.79	0.00e+00	953.00
IUUC-Dor-030480	Dipodomys ordii	77.74	7.00e-136	478.00
IUUC-Ete-032316	Echinops telfairi	59.76	0.00e+00	876.00
IUUC-Eca-034130	Equus caballus	76.37	0.00e+00	1177.00
IUUC-Fca-035480	Felis catus	73.88	0.00e+00	691.00
IUUC-Ggo-045449	Gorilla gorilla	84.48	0.00e+00	1268.00
IUUC-Laf-053984	Loxodonta africana	73.27	0.00e+00	653.00
IUUC-Mcc-055647	Macaca mulatta	91.45	0.00e+00	1385.00
IUUC-Mga-060031	Meleagris gallopavo	31.41	3.00e-85	309.00
IUUC-Mmr-060724	Microcebus murinus	60.59	0.00e+00	785.00
IUUC-Mmu-063285	Mus musculus	67.62	6.00e-176	610.00
IUUC-Mpu-066802	Mustela putorius furo	69.67	1.00e-174	605.00
IUUC-Mlu-067658	Myotis lucifugus	74.39	0.00e+00	1140.00
IUUC-Nle-069376	Nomascus leucogenys	90.93	0.00e+00	1381.00
IUUC-Ocu-073956	Oryctolagus cuniculus	63.39	0.00e+00	919.00
IUUC-Oar-089984	Ovis aries	71.43	7.00e-179	620.00
IUUC-Ptr-091205	Pan troglodytes	99.18	0.00e+00	875.00
IUUC-Pan-091941	Papio anubis	94.67	0.00e+00	839.00
IUUC-Pab-098713	Pongo abelii	97.15	0.00e+00	1516.00
IUUC-Pca-100258	Procavia capensis	69.15	0.00e+00	699.00
IUUC-Pva-102482	Pteropus vampyrus	69.00	0.00e+00	767.00
IUUC-Rno-105230	Rattus norvegicus	66.87	9.00e-168	583.00
IUUC-Sha-107352	Sarcophilus harrisii	27.14	4.00e-66	246.00
IUUC-Ssc-115780	Sus scrofa	69.57	0.00e+00	1019.00
IUUC-Tsy-119181	Tarsius syrichta	77.58	1.00e-180	627.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence