iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	PHOSIDA	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	15983046; 15071497; 16227972; 18680552

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	5.70e-11	44.3	30	99
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.20e-08	32.1	132	162

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           +D  lv++gee++++k +Laa+S++ +  ++ + + +  s+ ++e+++++  v+r++l+++ +g++++ne
   Q: 30   CDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPkDDGSTYKIELEGISVMVMREILDYIFSGQIRLNE 99
           899***************************888884666666666668*******************997 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eNc+gi++fA +y++++++  a +++++hF+
   Q: 132  ENCIGIRDFALHYCLHHVHYLATEYLETHFR 162
           9*****************************7 PP

Organism

Homo sapiens

Functional Description
(View)

Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.

Protein Sequence
(Fasta)

MAEGSAVSDP QHAARLLRAL SSFREESRFC DAHLVLDGEE IPVQKNILAA ASPYIRTKLN 60
YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED TIQDVVQAAD LLLLTDLKTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCGCCGC GGATAGCACA GGCACGTCCC GGGGGCTCCA GCTTCTGCTC AGAGCGCGGA 60
GAGCCGGGCC GGGCGGGCGC GCGCGCAGGA CTCGGGCCGC TCGAGGGGTC CGGCCGGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-0523--Neurodegeneration
KW-0622--Neuropathy
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030579--KLHL16
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0007010--P:cytoskeleton organization
GO:0016567--P:protein ubiquitination

KEGG

hsa:8139

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002164	Ailuropoda melanoleuca	98.35	0.00e+00	1075.00
IUUC-Apl-004132	Anas platyrhynchos	91.22	0.00e+00	1011.00
IUUC-Aca-005264	Anolis carolinensis	90.25	0.00e+00	1090.00
IUUC-Ame-011222	Astyanax mexicanus	69.52	0.00e+00	702.00
IUUC-Bta-012855	Bos taurus	98.49	0.00e+00	1176.00
IUUC-Cja-019865	Callithrix jacchus	98.99	0.00e+00	1180.00
IUUC-Cfa-020864	Canis familiaris	99.16	0.00e+00	1185.00
IUUC-Cpo-021500	Cavia porcellus	98.32	0.00e+00	1172.00
IUUC-Csa-023114	Chlorocebus sabaeus	100.00	0.00e+00	1194.00
IUUC-Cho-024996	Choloepus hoffmanni	98.52	0.00e+00	1063.00
IUUC-Dre-028758	Danio rerio	68.71	1.00e-180	626.00
IUUC-Dno-029380	Dasypus novemcinctus	98.82	0.00e+00	1167.00
IUUC-Dor-030704	Dipodomys ordii	98.45	0.00e+00	774.00
IUUC-Ete-032632	Echinops telfairi	97.49	0.00e+00	1162.00
IUUC-Eca-034092	Equus caballus	98.72	0.00e+00	1076.00
IUUC-Eeu-034482	Erinaceus europaeus	92.99	0.00e+00	1088.00
IUUC-Fca-035706	Felis catus	98.72	0.00e+00	1074.00
IUUC-Fal-037414	Ficedula albicollis	91.65	0.00e+00	957.00
IUUC-Gmo-039716	Gadus morhua	68.02	0.00e+00	859.00
IUUC-Gga-040801	Gallus gallus	91.62	0.00e+00	1108.00
IUUC-Gac-042023	Gasterosteus aculeatus	67.62	0.00e+00	865.00
IUUC-Ggo-045209	Gorilla gorilla	99.63	0.00e+00	1087.00
IUUC-Itr-048003	Ictidomys tridecemlineatus	99.11	0.00e+00	904.00
IUUC-Lch-050253	Latimeria chalumnae	82.21	0.00e+00	988.00
IUUC-Loc-052224	Lepisosteus oculatus	80.68	0.00e+00	968.00
IUUC-Laf-054497	Loxodonta africana	98.15	0.00e+00	1165.00
IUUC-Mcc-055363	Macaca mulatta	100.00	0.00e+00	1194.00
IUUC-Meu-056415	Macropus eugenii	88.27	0.00e+00	1038.00
IUUC-Mga-059506	Meleagris gallopavo	91.53	0.00e+00	1010.00
IUUC-Mmr-060695	Microcebus murinus	99.16	0.00e+00	1184.00
IUUC-Mdo-062539	Monodelphis domestica	95.48	0.00e+00	1149.00
IUUC-Mmu-063833	Mus musculus	98.32	0.00e+00	1177.00
IUUC-Mpu-066163	Mustela putorius furo	99.00	0.00e+00	1181.00
IUUC-Mlu-067351	Myotis lucifugus	99.16	0.00e+00	1185.00
IUUC-Nle-069432	Nomascus leucogenys	99.83	0.00e+00	1192.00
IUUC-Opr-070941	Ochotona princeps	88.54	0.00e+00	929.00
IUUC-Ont-072620	Oreochromis niloticus	69.70	0.00e+00	891.00
IUUC-Oan-073408	Ornithorhynchus anatinus	94.20	1.00e-148	518.00
IUUC-Ocu-074067	Oryctolagus cuniculus	98.32	0.00e+00	1174.00
IUUC-Ola-087263	Oryzias latipes	67.85	0.00e+00	858.00
IUUC-Oga-088387	Otolemur garnettii	98.50	0.00e+00	1179.00
IUUC-Oar-089890	Ovis aries	97.62	0.00e+00	1059.00
IUUC-Ptr-090867	Pan troglodytes	100.00	0.00e+00	1080.00
IUUC-Pan-092790	Papio anubis	99.63	0.00e+00	1087.00
IUUC-Psi-093381	Pelodiscus sinensis	92.04	0.00e+00	923.00
IUUC-Pma-094681	Petromyzon marinus	67.26	6.00e-157	547.00
IUUC-Pfo-096446	Poecilia formosa	67.85	0.00e+00	874.00
IUUC-Pab-097839	Pongo abelii	100.00	0.00e+00	1193.00
IUUC-Pca-101042	Procavia capensis	81.75	1.00e-121	429.00
IUUC-Pva-102911	Pteropus vampyrus	99.33	0.00e+00	1185.00
IUUC-Rno-105073	Rattus norvegicus	96.85	0.00e+00	1167.00
IUUC-Sha-107321	Sarcophilus harrisii	94.30	0.00e+00	1165.00
IUUC-Sar-113417	Sorex araneus	87.80	0.00e+00	920.00
IUUC-Ssc-115450	Sus scrofa	98.66	0.00e+00	1180.00
IUUC-Tgu-117089	Taeniopygia guttata	91.25	0.00e+00	1090.00
IUUC-Tru-118452	Takifugu rubripes	65.14	0.00e+00	822.00
IUUC-Tsy-119125	Tarsius syrichta	93.60	0.00e+00	892.00
IUUC-Tni-120845	Tetraodon nigroviridis	64.55	0.00e+00	817.00
IUUC-Tbe-127688	Tupaia belangeri	69.18	1.00e-113	403.00
IUUC-Ttr-128621	Tursiops truncatus	98.26	0.00e+00	918.00
IUUC-Vpa-130159	Vicugna pacos	99.35	0.00e+00	626.00
IUUC-Xtr-132635	Xenopus tropicalis	84.06	0.00e+00	999.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence