iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048841

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01066137

Gene Name

OTUD7B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000026621.1	ENSSTOT00000025913.1	ENSSTOP00000020136.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.20e-37	128.5	184	365
UBD/ZnF/ZnF_A20	8.50e-17	60.8	796	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAASLGMWGFHDRDLmLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98877 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  lgtN-GangggvesseepvyeslEEFHVFVLAHVLRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 360
           7540.366689****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 796  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 830
           59********************************9 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLPPPFSEGN 60
SGSKTSEKGC SDRESTRPLR PILQRQDDII QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCCTGG ACATGGATGC TGTCCTGTCG GATTTTGTCC GTTCCACAGG AGCAGAGCCA 60
GGGTTGGCCC GTGATCTCCT GGAAGGTAAG CAGTCAAGGG TGAGAAAGAA GAAACTAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0035871--P:protein K11-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002119	Ailuropoda melanoleuca	94.05	0.00e+00	1445.00
IUUC-Apl-003567	Anas platyrhynchos	65.61	0.00e+00	954.00
IUUC-Aca-004392	Anolis carolinensis	53.58	0.00e+00	812.00
IUUC-Ame-011052	Astyanax mexicanus	73.93	0.00e+00	717.00
IUUC-Bta-013398	Bos taurus	95.61	0.00e+00	1425.00
IUUC-Cel-018468	Caenorhabditis elegans	50.67	3.00e-85	309.00
IUUC-Cja-019965	Callithrix jacchus	93.14	0.00e+00	1376.00
IUUC-Cfa-020191	Canis familiaris	94.54	0.00e+00	1449.00
IUUC-Cpo-022232	Cavia porcellus	92.30	0.00e+00	1375.00
IUUC-Csa-023593	Chlorocebus sabaeus	94.90	0.00e+00	1478.00
IUUC-Cho-024729	Choloepus hoffmanni	86.52	0.00e+00	633.00
IUUC-Csv-026177	Ciona savignyi	30.56	4.00e-03	34.70
IUUC-Dre-028617	Danio rerio	61.98	0.00e+00	750.00
IUUC-Dno-029900	Dasypus novemcinctus	93.92	0.00e+00	1404.00
IUUC-Dor-031121	Dipodomys ordii	86.77	0.00e+00	702.00
IUUC-Ete-032473	Echinops telfairi	88.33	0.00e+00	1031.00
IUUC-Eca-033946	Equus caballus	95.49	0.00e+00	1047.00
IUUC-Eeu-034670	Erinaceus europaeus	92.29	0.00e+00	1392.00
IUUC-Fca-035871	Felis catus	94.42	0.00e+00	1348.00
IUUC-Fal-037145	Ficedula albicollis	73.79	0.00e+00	736.00
IUUC-Fso-038203	Fusarium solani	30.93	1.50e-02	35.00
IUUC-Gmo-039373	Gadus morhua	77.25	0.00e+00	680.00
IUUC-Gga-041105	Gallus gallus	67.95	0.00e+00	983.00
IUUC-Gac-041806	Gasterosteus aculeatus	78.11	0.00e+00	726.00
IUUC-Ggo-045472	Gorilla gorilla	94.90	0.00e+00	1438.00
IUUC-Hsa-046473	Homo sapiens	94.66	0.00e+00	1439.00
IUUC-Lch-050432	Latimeria chalumnae	64.26	0.00e+00	958.00
IUUC-Loc-052841	Lepisosteus oculatus	75.10	0.00e+00	736.00
IUUC-Laf-053437	Loxodonta africana	70.58	0.00e+00	694.00
IUUC-Mcc-055261	Macaca mulatta	94.66	0.00e+00	1479.00
IUUC-Meu-056477	Macropus eugenii	80.37	0.00e+00	946.00
IUUC-Mga-059533	Meleagris gallopavo	69.99	0.00e+00	984.00
IUUC-Mdo-062847	Monodelphis domestica	83.41	0.00e+00	1167.00
IUUC-Mmu-064260	Mus musculus	90.28	0.00e+00	1346.00
IUUC-Mpu-066876	Mustela putorius furo	89.59	0.00e+00	1338.00
IUUC-Mlu-068039	Myotis lucifugus	94.31	0.00e+00	1420.00
IUUC-Nle-069260	Nomascus leucogenys	94.42	0.00e+00	1436.00
IUUC-Opr-070564	Ochotona princeps	92.06	0.00e+00	788.00
IUUC-Ont-072431	Oreochromis niloticus	73.74	0.00e+00	714.00
IUUC-Oan-073235	Ornithorhynchus anatinus	69.76	0.00e+00	654.00
IUUC-Ocu-073824	Oryctolagus cuniculus	95.19	0.00e+00	954.00
IUUC-Opu-083273	Oryza punctata	23.38	3.70e-01	29.60
IUUC-Ola-086490	Oryzias latipes	75.37	0.00e+00	692.00
IUUC-Oga-088124	Otolemur garnettii	95.14	0.00e+00	1417.00
IUUC-Oar-090086	Ovis aries	95.73	0.00e+00	1428.00
IUUC-Ptr-091622	Pan troglodytes	95.43	0.00e+00	1092.00
IUUC-Pan-092724	Papio anubis	94.66	0.00e+00	1475.00
IUUC-Psi-093333	Pelodiscus sinensis	65.38	0.00e+00	947.00
IUUC-Pfo-096785	Poecilia formosa	73.63	0.00e+00	724.00
IUUC-Pab-098667	Pongo abelii	94.42	0.00e+00	1420.00
IUUC-Pca-100701	Procavia capensis	93.22	0.00e+00	761.00
IUUC-Pva-102136	Pteropus vampyrus	93.36	0.00e+00	1404.00
IUUC-Rno-105546	Rattus norvegicus	91.47	0.00e+00	1375.00
IUUC-Sha-106732	Sarcophilus harrisii	83.33	0.00e+00	1082.00
IUUC-Sar-113562	Sorex araneus	81.04	0.00e+00	1115.00
IUUC-Ssc-116191	Sus scrofa	95.85	0.00e+00	1452.00
IUUC-Tgu-116942	Taeniopygia guttata	76.17	0.00e+00	789.00
IUUC-Tru-118720	Takifugu rubripes	70.23	0.00e+00	673.00
IUUC-Tsy-119343	Tarsius syrichta	85.60	0.00e+00	1254.00
IUUC-Tni-120795	Tetraodon nigroviridis	72.37	0.00e+00	695.00
IUUC-Tbe-127283	Tupaia belangeri	84.57	0.00e+00	788.00
IUUC-Ttr-128692	Tursiops truncatus	92.17	0.00e+00	1345.00
IUUC-Xtr-132888	Xenopus tropicalis	61.44	0.00e+00	866.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence