iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097670

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Polycomb complex protein BMI-1; Polycomb group RING finger protein 4

Genbank Nucleotide ID

CR859740

Gene Name

BMI1; PCGF4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000002144.2	ENSPPYT00000002567.2	ENSPPYP00000002492.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.70e-06	27.9	18	57
ULD/UDP/UFD/RAWUL	1.20e-30	106.0	131	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 18   CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 57
           ********99999****************......**********5 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk..........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkeg 79
           isls+e++++n+ +++ +          ++k+ylrc+a++tV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++g
   Q: 131  ISLSIEFFDQNRLDRKVNkdkekskeevNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNG 219
           7899999999998887768888899999************************************************************* PP
   S: 80   pLvLqYr 86
           pL+L+Yr
   Q: 220  PLPLKYR 226
           ******9 PP

Organism

Pongo abelii

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTTTTAT CAAGCAGAAA TGCATCGAAC AACGAGAATC AAGATCACTG AGCTAAATCC 60
CCACCTGATG TGTGTGCTTT GTGGAGGGTA CTTCATTGAT GCCACAACCA TAATAGAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000792--C:heterochromatin
GO:0016604--C:nuclear body
GO:0031519--C:PcG protein complex
GO:0000151--C:ubiquitin ligase complex
GO:1990841--F:promoter-specific chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0006306--P:DNA methylation
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0016574--P:histone ubiquitination
GO:0006959--P:humoral immune response
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030890--P:positive regulation of B cell proliferation
GO:0033092--P:positive regulation of immature T cell proliferation in thymus
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0021903--P:rostrocaudal neural tube patterning
GO:0048103--P:somatic stem cell division
GO:0006351--P:transcription, DNA-templated

KEGG

pon:100173052

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000603	Aegilops tauschii	37.21	5.00e-12	65.50
IUUC-Aml-001498	Ailuropoda melanoleuca	98.77	3.00e-170	590.00
IUUC-Apl-004208	Anas platyrhynchos	95.14	8.00e-136	476.00
IUUC-Aca-004661	Anolis carolinensis	83.44	1.00e-139	489.00
IUUC-Ath-007649	Arabidopsis thaliana	42.50	3.00e-12	66.20
IUUC-Ame-010610	Astyanax mexicanus	72.64	3.00e-138	484.00
IUUC-Bta-012606	Bos taurus	99.08	3.00e-171	593.00
IUUC-Cja-019482	Callithrix jacchus	99.68	0.00e+00	627.00
IUUC-Cfa-020482	Canis familiaris	98.77	3.00e-170	590.00
IUUC-Cpo-022061	Cavia porcellus	99.68	0.00e+00	628.00
IUUC-Csa-024102	Chlorocebus sabaeus	100.00	0.00e+00	632.00
IUUC-Cho-025081	Choloepus hoffmanni	81.93	1.00e-112	398.00
IUUC-Cin-025612	Ciona intestinalis	49.07	3.00e-52	199.00
IUUC-Dre-027929	Danio rerio	79.75	4.00e-142	497.00
IUUC-Dno-029797	Dasypus novemcinctus	98.09	0.00e+00	645.00
IUUC-Dor-030256	Dipodomys ordii	96.50	7.00e-169	586.00
IUUC-Dme-031904	Drosophila melanogaster	45.02	3.00e-53	204.00
IUUC-Ete-033148	Echinops telfairi	64.71	5.00e-83	300.00
IUUC-Eca-033318	Equus caballus	99.39	1.00e-171	595.00
IUUC-Eeu-034547	Erinaceus europaeus	86.31	4.00e-150	523.00
IUUC-Fca-035866	Felis catus	99.39	3.00e-171	593.00
IUUC-Fal-036660	Ficedula albicollis	96.01	7.00e-161	559.00
IUUC-Gmo-039341	Gadus morhua	82.69	1.00e-125	442.00
IUUC-Gga-040611	Gallus gallus	95.54	4.00e-166	577.00
IUUC-Gac-041888	Gasterosteus aculeatus	72.49	1.00e-128	452.00
IUUC-Ggo-045027	Gorilla gorilla	100.00	0.00e+00	629.00
IUUC-Hsa-045665	Homo sapiens	100.00	0.00e+00	632.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	99.36	5.00e-179	619.00
IUUC-Lch-049714	Latimeria chalumnae	86.24	2.00e-164	570.00
IUUC-Loc-052161	Lepisosteus oculatus	81.35	1.00e-143	501.00
IUUC-Laf-054108	Loxodonta africana	97.80	6.00e-179	619.00
IUUC-Mcc-055562	Macaca mulatta	100.00	0.00e+00	632.00
IUUC-Meu-056709	Macropus eugenii	97.85	7.00e-174	602.00
IUUC-Mtr-058158	Medicago truncatula	43.42	4.00e-10	57.40
IUUC-Mga-060104	Meleagris gallopavo	92.77	2.00e-120	424.00
IUUC-Mmr-061191	Microcebus murinus	100.00	0.00e+00	632.00
IUUC-Mdo-062711	Monodelphis domestica	93.17	1.00e-153	535.00
IUUC-Mmu-064255	Mus musculus	95.22	5.00e-167	579.00
IUUC-Mpu-066466	Mustela putorius furo	98.47	2.00e-170	591.00
IUUC-Mlu-067622	Myotis lucifugus	99.36	0.00e+00	625.00
IUUC-Nle-069253	Nomascus leucogenys	100.00	0.00e+00	632.00
IUUC-Opr-070511	Ochotona princeps	99.04	1.00e-179	621.00
IUUC-Ont-072177	Oreochromis niloticus	84.23	1.00e-129	455.00
IUUC-Oan-073336	Ornithorhynchus anatinus	97.55	2.00e-171	594.00
IUUC-Ocu-074113	Oryctolagus cuniculus	99.36	8.00e-171	592.00
IUUC-Oba-075690	Oryza barthii	42.25	7.00e-12	65.10
IUUC-Ogl-077513	Oryza glaberrima	42.25	8.00e-12	65.10
IUUC-Oni-082398	Oryza nivara	42.25	8.00e-12	65.10
IUUC-Oru-084965	Oryza rufipogon	42.25	9.00e-12	65.10
IUUC-Ola-087057	Oryzias latipes	85.19	8.00e-124	436.00
IUUC-Oga-088346	Otolemur garnettii	100.00	0.00e+00	629.00
IUUC-Oar-089843	Ovis aries	99.08	3.00e-171	593.00
IUUC-Ptr-090486	Pan troglodytes	100.00	0.00e+00	629.00
IUUC-Pan-092667	Papio anubis	100.00	4.00e-160	557.00
IUUC-Psi-093469	Pelodiscus sinensis	95.40	3.00e-173	600.00
IUUC-Pma-094481	Petromyzon marinus	74.04	7.00e-90	322.00
IUUC-Pfo-097156	Poecilia formosa	79.73	2.00e-133	468.00
IUUC-Pop-099100	Populus trichocarpa	37.65	1.00e-12	67.40
IUUC-Pva-102800	Pteropus vampyrus	100.00	0.00e+00	629.00
IUUC-Rno-105128	Rattus norvegicus	94.59	5.00e-170	589.00
IUUC-Sha-106747	Sarcophilus harrisii	97.85	3.00e-163	566.00
IUUC-Sar-113416	Sorex araneus	99.36	1.00e-180	624.00
IUUC-Ssc-115864	Sus scrofa	99.68	0.00e+00	628.00
IUUC-Tgu-116851	Taeniopygia guttata	95.14	2.00e-136	478.00
IUUC-Tru-117698	Takifugu rubripes	86.18	2.00e-124	438.00
IUUC-Tsy-119590	Tarsius syrichta	99.36	0.00e+00	625.00
IUUC-Tni-120170	Tetraodon nigroviridis	83.85	1.00e-128	452.00
IUUC-Tae-123760	Triticum aestivum	37.21	5.00e-12	65.90
IUUC-Tur-126396	Triticum urartu	37.21	6.00e-12	65.10
IUUC-Tbe-127790	Tupaia belangeri	99.68	0.00e+00	627.00
IUUC-Ttr-129316	Tursiops truncatus	99.39	1.00e-180	625.00
IUUC-Vpa-130669	Vicugna pacos	99.69	5.00e-172	596.00
IUUC-Xtr-131912	Xenopus tropicalis	87.77	7.00e-148	516.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence