iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
circBase	CircNet	miRTarBase	microRNA
TRANSFAC	TargetScan
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.20e-13	52.0	24	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D+ ++v+g+ f+ah+ +L a S +F+al+ +   +s  +++  ++ v  ++f+ +l+FlY+gkld+
   Q: 24   CDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLYSGKLDL 90
           8**********************************998677777777******************96 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR ALLIHYIQDS 60
GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS AASYLQMNDV VNFCKTYIRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCTCCGT GGCTGCGCTG CTGGAACCCG CTGGAAGGTG AGCGCGAAGA AGCGGGTTGG 60
CGCTGCCGCT TTCGTTGGTT TGGGGAGGAT TCCTAGCACC CGGGAGGCTG GCTGGAGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:728116

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001711	Ailuropoda melanoleuca	80.61	0.00e+00	750.00
IUUC-Apl-003361	Anas platyrhynchos	76.53	0.00e+00	683.00
IUUC-Ame-011033	Astyanax mexicanus	50.58	6.00e-120	424.00
IUUC-Bta-013337	Bos taurus	75.98	4.00e-129	454.00
IUUC-Cja-019716	Callithrix jacchus	94.58	4.00e-160	557.00
IUUC-Cfa-020734	Canis familiaris	88.53	0.00e+00	813.00
IUUC-Csa-023327	Chlorocebus sabaeus	98.38	0.00e+00	827.00
IUUC-Cho-024404	Choloepus hoffmanni	80.09	6.00e-180	623.00
IUUC-Dre-028433	Danio rerio	47.70	4.00e-118	418.00
IUUC-Dno-030078	Dasypus novemcinctus	88.69	0.00e+00	788.00
IUUC-Dor-030579	Dipodomys ordii	71.52	3.00e-118	418.00
IUUC-Eca-033763	Equus caballus	90.30	0.00e+00	796.00
IUUC-Fca-035383	Felis catus	87.27	0.00e+00	834.00
IUUC-Fal-036755	Ficedula albicollis	72.43	0.00e+00	666.00
IUUC-Gac-041597	Gasterosteus aculeatus	50.22	3.00e-107	382.00
IUUC-Itr-048495	Ictidomys tridecemlineatus	92.15	0.00e+00	830.00
IUUC-Lch-050366	Latimeria chalumnae	64.47	0.00e+00	628.00
IUUC-Loc-052862	Lepisosteus oculatus	59.50	6.00e-75	275.00
IUUC-Laf-053821	Loxodonta africana	89.72	0.00e+00	813.00
IUUC-Meu-056063	Macropus eugenii	96.55	3.00e-63	235.00
IUUC-Mga-059691	Meleagris gallopavo	74.10	0.00e+00	682.00
IUUC-Mmr-060726	Microcebus murinus	92.45	0.00e+00	783.00
IUUC-Mdo-062181	Monodelphis domestica	76.00	0.00e+00	674.00
IUUC-Mmu-063232	Mus musculus	82.63	0.00e+00	776.00
IUUC-Mpu-065702	Mustela putorius furo	84.85	0.00e+00	769.00
IUUC-Mlu-067998	Myotis lucifugus	83.43	0.00e+00	774.00
IUUC-Oan-073207	Ornithorhynchus anatinus	71.80	0.00e+00	657.00
IUUC-Ocu-074665	Oryctolagus cuniculus	84.31	0.00e+00	790.00
IUUC-Ola-086838	Oryzias latipes	49.80	3.00e-113	402.00
IUUC-Oga-088751	Otolemur garnettii	87.47	0.00e+00	784.00
IUUC-Oar-089215	Ovis aries	84.68	0.00e+00	762.00
IUUC-Ptr-090564	Pan troglodytes	99.60	0.00e+00	868.00
IUUC-Pan-092429	Papio anubis	98.18	0.00e+00	854.00
IUUC-Psi-093428	Pelodiscus sinensis	72.60	8.00e-180	623.00
IUUC-Pma-094564	Petromyzon marinus	33.02	7.00e-50	191.00
IUUC-Pab-098438	Pongo abelii	98.18	0.00e+00	863.00
IUUC-Rno-105751	Rattus norvegicus	83.23	0.00e+00	781.00
IUUC-Sar-113636	Sorex araneus	96.35	2.00e-71	263.00
IUUC-Tgu-117425	Taeniopygia guttata	69.29	0.00e+00	644.00
IUUC-Tru-118498	Takifugu rubripes	80.16	9.00e-55	207.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence