iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108086

Ensembl Protein ID

SPBC146.06c.1:pep

UniProt Accession

Q9Y804; FAN1_SCHPO

Genbank Protein ID

CAB46759.1

Protein Name

Fanconi-associated nuclease 1 homolog

Genbank Nucleotide ID

CU329671

Gene Name

fan1; SPBC146.06c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC146.06c	SPBC146.06c.1	SPBC146.06c.1:pep

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	24.82	6.00e-42	170.00	IUUC-Hsa-046520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Nuclease required for the repair of DNA interstrand cross-links (ICL) (PubMed:24192486, PubMed:25319828). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity).

Protein Sequence
(Fasta)

MKRFFNEACD INTPDKSGVN ENKLCFPPLK VVCQAPETTV KGQVANTNKH NVYSTKNSMY 60
LLGFEEILNT VLDCEPHIFT DDELRVIENF KALDSDERYL FVRLFMRKRN KWFRVGHLTY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTTGTTGAC TTACATTTTC TTTTTAGTTT CAAATAGCAA CTTTCGCTAA ACTTGCATTA 60
TAGACAACAC TGTAACTTAC GAATGCAGTT AAATTTTCAA AAGCATTTAT TTAAACTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR033315--Fan1-like
IPR014883--VRR_NUC

Pfam

PF08774--VRR_NUC

SMART

SM00990--VRR_NUC

Gene Ontology

GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0046872--F:metal ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair

KEGG

spo:SPBC146.06c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000306	Aegilops tauschii	27.92	2.00e-39	154.00
IUUC-Aml-001380	Ailuropoda melanoleuca	25.71	2.00e-49	189.00
IUUC-Atr-002873	Amborella trichopoda	28.62	9.00e-64	236.00
IUUC-Apl-003430	Anas platyrhynchos	26.56	8.00e-52	197.00
IUUC-Aca-005376	Anolis carolinensis	25.22	4.00e-44	171.00
IUUC-Aly-005463	Arabidopsis lyrata	38.44	5.00e-51	194.00
IUUC-Ath-007392	Arabidopsis thaliana	38.31	1.00e-51	196.00
IUUC-Acl-008285	Aspergillus clavatus	32.82	9.00e-103	365.00
IUUC-Afl-008680	Aspergillus flavus	32.51	1.00e-102	365.00
IUUC-Afu-008795	Aspergillus fumigatus	34.79	2.00e-105	374.00
IUUC-Ani-009329	Aspergillus nidulans	30.97	5.00e-86	310.00
IUUC-Ang-009526	Aspergillus niger	29.93	1.00e-83	302.00
IUUC-Aor-009880	Aspergillus oryzae	32.17	7.00e-103	366.00
IUUC-Ate-010269	Aspergillus terreus	34.05	2.00e-107	381.00
IUUC-Ame-011630	Astyanax mexicanus	25.09	1.00e-34	139.00
IUUC-Bgr-012168	Blumeria graminis	29.20	1.00e-71	262.00
IUUC-Bta-013504	Bos taurus	26.13	8.00e-44	170.00
IUUC-Bci-013838	Botrytis cinerea	30.34	4.00e-100	357.00
IUUC-Bdi-014522	Brachypodium distachyon	26.82	6.00e-49	187.00
IUUC-Bol-016153	Brassica oleracea	30.11	1.00e-66	246.00
IUUC-Bra-017548	Brassica rapa	30.35	8.00e-61	226.00
IUUC-Cel-018711	Caenorhabditis elegans	23.90	5.00e-27	114.00
IUUC-Cja-018810	Callithrix jacchus	25.74	3.00e-40	158.00
IUUC-Cfa-020147	Canis familiaris	25.74	3.00e-46	178.00
IUUC-Cpo-021787	Cavia porcellus	27.23	7.00e-50	190.00
IUUC-Csa-023730	Chlorocebus sabaeus	26.26	6.00e-47	181.00
IUUC-Cho-024754	Choloepus hoffmanni	35.90	5.00e-12	64.30
IUUC-Cin-025459	Ciona intestinalis	41.57	2.00e-25	106.00
IUUC-Cgl-026724	Colletotrichum gloeosporioides	31.42	7.00e-88	316.00
IUUC-Cne-026815	Cryptococcus neoformans	27.12	5.00e-49	187.00
IUUC-Cme-027208	Cyanidioschyzon merolae	30.94	2.00e-24	105.00
IUUC-Dre-027725	Danio rerio	26.32	6.00e-61	227.00
IUUC-Dno-029713	Dasypus novemcinctus	24.79	3.00e-47	181.00
IUUC-Dse-031534	Dothistroma septosporum	28.78	7.00e-95	339.00
IUUC-Ete-033004	Echinops telfairi	32.14	5.00e-15	74.70
IUUC-Eca-034119	Equus caballus	26.04	2.00e-47	182.00
IUUC-Eeu-034618	Erinaceus europaeus	30.15	3.00e-34	138.00
IUUC-Fca-035411	Felis catus	25.48	6.00e-47	180.00
IUUC-Fal-037505	Ficedula albicollis	24.41	8.00e-47	180.00
IUUC-Fox-038070	Fusarium oxysporum	31.91	4.00e-99	353.00
IUUC-Fso-038376	Fusarium solani	33.56	7.00e-105	372.00
IUUC-Gmo-039093	Gadus morhua	26.28	4.00e-55	207.00
IUUC-Ggr-040081	Gaeumannomyces graminis	31.59	1.00e-100	359.00
IUUC-Gac-041973	Gasterosteus aculeatus	25.40	5.00e-55	207.00
IUUC-Gma-043421	Glycine max	28.98	2.00e-61	228.00
IUUC-Ggo-044431	Gorilla gorilla	26.14	2.00e-48	186.00
IUUC-Hsa-046520	Homo sapiens	26.14	1.00e-47	182.00
IUUC-Hvu-047632	Hordeum vulgare	25.94	2.00e-53	202.00
IUUC-Itr-048263	Ictidomys tridecemlineatus	25.93	8.00e-49	187.00
IUUC-Lch-049799	Latimeria chalumnae	26.48	6.00e-57	214.00
IUUC-Lpe-051149	Leersia perrieri	26.23	1.00e-58	219.00
IUUC-Loc-051964	Lepisosteus oculatus	24.90	6.00e-51	194.00
IUUC-Lma-053161	Leptosphaeria maculans	30.52	3.00e-106	377.00
IUUC-Laf-054446	Loxodonta africana	26.65	7.00e-51	194.00
IUUC-Mcc-055087	Macaca mulatta	26.26	5.00e-47	181.00
IUUC-Meu-055930	Macropus eugenii	27.08	2.00e-20	92.00
IUUC-Mor-056966	Magnaporthe oryzae	30.12	7.00e-97	346.00
IUUC-Mpo-057393	Magnaporthe poae	30.17	3.00e-85	307.00
IUUC-Mtr-058315	Medicago truncatula	29.36	5.00e-65	240.00
IUUC-Mla-058859	Melampsora laricipopulina	33.78	4.00e-69	254.00
IUUC-Mga-059870	Meleagris gallopavo	25.88	8.00e-44	170.00
IUUC-Mvi-060226	Microbotryum violaceum	31.31	2.00e-76	278.00
IUUC-Mmr-060892	Microcebus murinus	25.46	7.00e-47	180.00
IUUC-Mdo-062896	Monodelphis domestica	26.94	1.00e-45	176.00
IUUC-Mmu-064276	Mus musculus	26.71	5.00e-53	201.00
IUUC-Mac-064503	Musa acuminata	27.46	4.00e-53	201.00
IUUC-Mpu-066820	Mustela putorius furo	24.21	2.00e-43	169.00
IUUC-Mlu-068131	Myotis lucifugus	26.27	7.00e-51	194.00
IUUC-Nfi-068480	Neosartorya fischeri	34.42	6.00e-103	366.00
IUUC-Ncr-068646	Neurospora crassa	32.05	2.00e-99	354.00
IUUC-Nle-069545	Nomascus leucogenys	26.06	1.00e-44	173.00
IUUC-Opr-070722	Ochotona princeps	27.25	8.00e-46	176.00
IUUC-Ont-072561	Oreochromis niloticus	25.25	1.00e-55	209.00
IUUC-Oan-072811	Ornithorhynchus anatinus	27.51	2.00e-50	192.00
IUUC-Ocu-073884	Oryctolagus cuniculus	26.31	1.00e-50	193.00
IUUC-Oba-075112	Oryza barthii	26.90	2.00e-50	192.00
IUUC-Obr-076057	Oryza brachyantha	26.05	1.00e-59	223.00
IUUC-Ogl-077002	Oryza glaberrima	27.27	1.00e-60	226.00
IUUC-Ogu-078683	Oryza glumaepatula	25.86	7.00e-49	187.00
IUUC-Oin-079952	Oryza indica	26.18	3.00e-47	181.00
IUUC-Olo-080278	Oryza longistaminata	28.01	3.00e-48	184.00
IUUC-Ome-081094	Oryza meridionalis	26.32	2.00e-47	182.00
IUUC-Oni-083059	Oryza nivara	25.31	6.00e-48	184.00
IUUC-Opu-084144	Oryza punctata	26.63	4.00e-57	214.00
IUUC-Oru-084897	Oryza rufipogon	25.14	4.00e-47	181.00
IUUC-Osa-085924	Oryza sativa	26.22	2.00e-58	219.00
IUUC-Oga-088979	Otolemur garnettii	26.05	3.00e-43	168.00
IUUC-Oar-090362	Ovis aries	26.88	6.00e-53	201.00
IUUC-Ptr-090823	Pan troglodytes	26.14	6.00e-48	184.00
IUUC-Pan-092863	Papio anubis	26.26	6.00e-47	181.00
IUUC-Psi-093006	Pelodiscus sinensis	24.54	5.00e-46	177.00
IUUC-Pma-094523	Petromyzon marinus	28.27	1.00e-40	159.00
IUUC-Pno-094770	Phaeosphaeria nodorum	32.50	4.00e-91	327.00
IUUC-Ppa-095372	Physcomitrella patens	28.49	1.00e-67	249.00
IUUC-Pfo-096875	Poecilia formosa	25.63	3.00e-56	211.00
IUUC-Pab-097665	Pongo abelii	26.44	1.00e-48	186.00
IUUC-Pop-099082	Populus trichocarpa	28.46	7.00e-64	237.00
IUUC-Pca-100138	Procavia capensis	42.86	2.00e-09	56.20
IUUC-Ppe-101167	Prunus persica	24.15	4.00e-14	71.60
IUUC-Pva-103199	Pteropus vampyrus	32.14	9.00e-17	79.70
IUUC-Pgr-103480	Puccinia graminis	32.25	5.00e-79	287.00
IUUC-Ptt-103783	Puccinia triticina	31.34	1.00e-64	239.00
IUUC-Pte-104357	Pyrenophora teres	32.16	3.00e-99	354.00
IUUC-Pyt-104788	Pyrenophora triticirepentis	31.67	1.00e-103	369.00
IUUC-Rno-104958	Rattus norvegicus	25.84	4.00e-53	201.00
IUUC-Sha-106828	Sarcophilus harrisii	26.84	2.00e-51	196.00
IUUC-Sja-107731	Schizosaccharomyces japonicus	44.09	5.00e-150	522.00
IUUC-Ssl-108610	Sclerotinia sclerotiorum	30.57	1.00e-94	339.00
IUUC-Smo-108690	Selaginella moellendorffii	30.63	2.00e-64	238.00
IUUC-Sit-110385	Setaria italica	32.48	1.00e-40	159.00
IUUC-Sly-111187	Solanum lycopersicum	28.12	2.00e-56	212.00
IUUC-Stu-112673	Solanum tuberosum	41.36	1.00e-28	116.00
IUUC-Sar-113548	Sorex araneus	20.33	3.00e-13	68.20
IUUC-Sbi-114131	Sorghum bicolor	27.03	2.00e-55	209.00
IUUC-Sre-114921	Sporisorium reilianum	38.31	1.00e-36	146.00
IUUC-Ssc-115484	Sus scrofa	26.95	2.00e-53	202.00
IUUC-Tgu-116749	Taeniopygia guttata	28.12	2.00e-45	175.00
IUUC-Tru-118772	Takifugu rubripes	26.14	9.00e-58	216.00
IUUC-Tsy-119359	Tarsius syrichta	22.74	9.00e-34	136.00
IUUC-Tni-120878	Tetraodon nigroviridis	25.96	2.00e-53	202.00
IUUC-Tca-120912	Theobroma cacao	29.60	5.00e-60	224.00
IUUC-Tre-122171	Trichoderma reesei	32.09	1.00e-106	379.00
IUUC-Tvi-122483	Trichoderma virens	31.36	3.00e-100	357.00
IUUC-Tae-125125	Triticum aestivum	25.24	1.00e-51	196.00
IUUC-Tur-126497	Triticum urartu	25.52	2.00e-52	199.00
IUUC-Tbe-127473	Tupaia belangeri	29.55	4.00e-14	70.90
IUUC-Ttr-128458	Tursiops truncatus	29.66	4.00e-36	145.00
IUUC-Uma-129558	Ustilago maydis	40.49	4.00e-40	158.00
IUUC-Vda-129683	Verticillium dahliae	33.70	5.00e-105	373.00
IUUC-Vpa-130201	Vicugna pacos	56.25	2.00e-04	39.30
IUUC-Vvi-131226	Vitis vinifera	29.74	4.00e-45	174.00
IUUC-Xtr-132517	Xenopus tropicalis	28.76	2.00e-38	152.00
IUUC-Xma-133763	Xiphophorus maculatus	25.77	3.00e-56	211.00
IUUC-Zma-135455	Zea mays	28.19	1.00e-64	239.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence