iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	6.10e-20	72.5	142	208

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgkld 66
           +Dv l+ +++ f++h+++Laa++++F+ l+++  e +  +  ++i+   ++   f+all++lYtg++ 
   Q: 142  TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA-EIIMDISTagIDMPMFSALLHYLYTGEFG 208
           79****************************99888876.6677777356****************975 PP

Organism

Mus musculus

Functional Description
(View)

Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression.

Protein Sequence
(Fasta)

MGANASNYPH SCSPRVGGNS QAQQTFIGTS SYSQQGYGCE SKLYSLDHGH EKPQDKKKRT 60
SGLATLKKKF IKRRKSNRSA DHAKQMRELL SGWDVRDVNA LVEEYEGTSA LKELSLQASL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGGCGACG GGGGGAACCT GGAGTGGTCC CGGAGCCTAA GCCACTGACA GGAGAGGGGA 60
GGGCGGCGGC GGCGGCTGGA GGAGAATGGC CGCGGGGGCT GGCGCCAGTG CGGACGACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0449--Lipoprotein
KW-0519--Myristate
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005634--C:nucleus
GO:0007275--P:multicellular organism development
GO:0060693--P:regulation of branching involved in salivary gland morphogenesis

KEGG

mmu:238386

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001669	Ailuropoda melanoleuca	92.76	0.00e+00	2003.00
IUUC-Apl-004146	Anas platyrhynchos	88.41	0.00e+00	1988.00
IUUC-Aca-004531	Anolis carolinensis	85.04	0.00e+00	1820.00
IUUC-Ame-011888	Astyanax mexicanus	66.46	0.00e+00	1338.00
IUUC-Bta-012739	Bos taurus	93.72	0.00e+00	2049.00
IUUC-Cja-019090	Callithrix jacchus	91.98	0.00e+00	2051.00
IUUC-Cfa-021272	Canis familiaris	93.36	0.00e+00	2011.00
IUUC-Cpo-021381	Cavia porcellus	89.77	0.00e+00	2018.00
IUUC-Csa-023734	Chlorocebus sabaeus	92.81	0.00e+00	1956.00
IUUC-Cho-024830	Choloepus hoffmanni	72.42	4.00e-130	459.00
IUUC-Dre-027552	Danio rerio	67.19	0.00e+00	1397.00
IUUC-Dno-028927	Dasypus novemcinctus	92.83	0.00e+00	2047.00
IUUC-Dor-030455	Dipodomys ordii	86.22	0.00e+00	1100.00
IUUC-Dme-031575	Drosophila melanogaster	46.53	3.00e-157	549.00
IUUC-Ete-032546	Echinops telfairi	81.33	0.00e+00	1656.00
IUUC-Eca-033548	Equus caballus	91.42	0.00e+00	1957.00
IUUC-Fca-036539	Felis catus	93.54	0.00e+00	2041.00
IUUC-Fal-037224	Ficedula albicollis	84.50	0.00e+00	1945.00
IUUC-Gmo-039413	Gadus morhua	80.36	0.00e+00	647.00
IUUC-Gga-040778	Gallus gallus	93.81	0.00e+00	735.00
IUUC-Gac-041839	Gasterosteus aculeatus	65.11	0.00e+00	1389.00
IUUC-Ggo-045450	Gorilla gorilla	93.12	0.00e+00	2043.00
IUUC-Hsa-046103	Homo sapiens	93.12	0.00e+00	2078.00
IUUC-Itr-048595	Ictidomys tridecemlineatus	98.97	0.00e+00	801.00
IUUC-Lch-050622	Latimeria chalumnae	80.62	0.00e+00	1780.00
IUUC-Loc-052889	Lepisosteus oculatus	73.84	0.00e+00	1563.00
IUUC-Laf-053392	Loxodonta africana	92.12	0.00e+00	2003.00
IUUC-Mcc-055838	Macaca mulatta	93.06	0.00e+00	2013.00
IUUC-Meu-056638	Macropus eugenii	78.10	0.00e+00	1469.00
IUUC-Mtr-058684	Medicago truncatula	30.43	2.00e-04	41.20
IUUC-Mga-059339	Meleagris gallopavo	86.78	0.00e+00	1973.00
IUUC-Mmr-061046	Microcebus murinus	92.50	0.00e+00	2034.00
IUUC-Mdo-062182	Monodelphis domestica	92.77	0.00e+00	1604.00
IUUC-Mpu-066893	Mustela putorius furo	93.01	0.00e+00	2034.00
IUUC-Mlu-067087	Myotis lucifugus	91.89	0.00e+00	2000.00
IUUC-Nle-069780	Nomascus leucogenys	92.95	0.00e+00	2008.00
IUUC-Opr-070487	Ochotona princeps	85.88	0.00e+00	990.00
IUUC-Ont-071582	Oreochromis niloticus	65.04	0.00e+00	1393.00
IUUC-Oan-072900	Ornithorhynchus anatinus	88.11	0.00e+00	1914.00
IUUC-Ocu-073746	Oryctolagus cuniculus	93.88	0.00e+00	1735.00
IUUC-Ola-086582	Oryzias latipes	64.62	0.00e+00	1370.00
IUUC-Oga-088013	Otolemur garnettii	92.43	0.00e+00	2011.00
IUUC-Oar-089234	Ovis aries	91.77	0.00e+00	2002.00
IUUC-Ptr-091490	Pan troglodytes	93.21	0.00e+00	2034.00
IUUC-Pan-092592	Papio anubis	93.06	0.00e+00	2012.00
IUUC-Psi-093163	Pelodiscus sinensis	88.24	0.00e+00	1895.00
IUUC-Pma-094133	Petromyzon marinus	55.01	7.00e-84	303.00
IUUC-Pfo-096674	Poecilia formosa	64.30	0.00e+00	1381.00
IUUC-Pab-098305	Pongo abelii	93.13	0.00e+00	2053.00
IUUC-Pva-102998	Pteropus vampyrus	92.30	0.00e+00	2051.00
IUUC-Rno-105445	Rattus norvegicus	97.17	0.00e+00	2044.00
IUUC-Sha-106737	Sarcophilus harrisii	89.12	0.00e+00	1904.00
IUUC-Sar-113474	Sorex araneus	97.60	0.00e+00	1186.00
IUUC-Ssc-116111	Sus scrofa	93.27	0.00e+00	2045.00
IUUC-Tgu-117204	Taeniopygia guttata	87.20	0.00e+00	1947.00
IUUC-Tru-118753	Takifugu rubripes	64.74	0.00e+00	1387.00
IUUC-Tsy-119632	Tarsius syrichta	90.67	0.00e+00	1966.00
IUUC-Tni-120088	Tetraodon nigroviridis	64.11	0.00e+00	1385.00
IUUC-Tbe-127435	Tupaia belangeri	95.41	0.00e+00	1337.00
IUUC-Ttr-128912	Tursiops truncatus	87.70	0.00e+00	1862.00
IUUC-Vpa-130654	Vicugna pacos	98.71	0.00e+00	1354.00
IUUC-Xtr-132530	Xenopus tropicalis	82.11	0.00e+00	1851.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence