iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000278644.2	ENST00000631566.1	ENSP00000488872.1
ENSG00000278644.2	ENST00000632316.1	ENSP00000487834.1
ENSG00000278644.2	ENST00000632510.1	ENSP00000487929.1

Annotation

Cancer Mutation
TCGA	CGAP	IntOGen
mRNA Expression
TCGA	ICGC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	PINA	Mentha	InWeb_IM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18211895
ULD/UDP/UFD/RAWUL	RAWUL	18588675; 21282530; 22325352

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.70e-06	28.2	18	56
ULD/UDP/UFD/RAWUL	2.60e-28	100.0	131	228

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           Ca+C   f d + ++ C H f+++C+ ++        ++ +CP C
   Q: 18   CALCGGYFIDATTIVECLHSFCKTCIVRY------LETNKYCPMC 56
           ********999999***************......********** PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk............lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegp 80
           +sls+e++e ++++d++k            +  ++lrc+a++tV+hl kfl++k++++s+y+v++l+ede+L++++tL++i+yi+ w+++gp
   Q: 131  VSLSIEFYEGARDRDEKKgplengdgdkekTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWRRNGP 222
           58899999999999988899999999999999************************************************************ PP
   S: 81   LvLqYr 86
           L+L+Yr
   Q: 223  LPLKYR 228
           *****9 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex (By similarity).

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV 60
HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCTGCAG GCTCGAGCTG GGGTCACTCG GCGGCCAGTG TGCGCAGGTC TCCTGGTCGC 60
CGGCCAGAGG GCGAAAGCAT TCACCCGAGG CCCCCAGCTT CGCGGCTGCC TTGGCTGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0070301--P:cellular response to hydrogen peroxide
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0001701--P:in utero embryonic development
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:7703

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002051	Ailuropoda melanoleuca	94.48	3.00e-157	547.00
IUUC-Aca-004230	Anolis carolinensis	74.72	3.00e-141	494.00
IUUC-Aly-005613	Arabidopsis lyrata	40.96	2.00e-12	66.60
IUUC-Bta-013298	Bos taurus	96.51	4.00e-165	573.00
IUUC-Cja-019674	Callithrix jacchus	98.84	7.00e-168	582.00
IUUC-Cfa-020865	Canis familiaris	89.94	3.00e-148	517.00
IUUC-Cpo-022149	Cavia porcellus	94.48	6.00e-162	563.00
IUUC-Csa-024153	Chlorocebus sabaeus	99.42	2.00e-168	584.00
IUUC-Dno-029941	Dasypus novemcinctus	94.48	4.00e-158	550.00
IUUC-Dor-030557	Dipodomys ordii	96.51	1.00e-162	565.00
IUUC-Eca-033878	Equus caballus	97.91	2.00e-153	534.00
IUUC-Eeu-035039	Erinaceus europaeus	92.15	2.00e-151	528.00
IUUC-Fca-036531	Felis catus	90.14	3.00e-143	501.00
IUUC-Gga-040311	Gallus gallus	84.09	7.00e-130	456.00
IUUC-Ggo-045132	Gorilla gorilla	99.71	2.00e-168	584.00
IUUC-Itr-048008	Ictidomys tridecemlineatus	98.55	2.00e-166	578.00
IUUC-Lch-050240	Latimeria chalumnae	73.47	3.00e-129	454.00
IUUC-Laf-053589	Loxodonta africana	97.38	4.00e-163	567.00
IUUC-Mcc-055228	Macaca mulatta	99.13	5.00e-167	580.00
IUUC-Meu-056268	Macropus eugenii	81.10	7.00e-135	473.00
IUUC-Mga-059555	Meleagris gallopavo	77.78	8.00e-84	303.00
IUUC-Mmr-060605	Microcebus murinus	97.96	4.00e-165	573.00
IUUC-Mdo-061947	Monodelphis domestica	81.90	5.00e-155	540.00
IUUC-Mmu-063845	Mus musculus	95.91	8.00e-162	563.00
IUUC-Mpu-066061	Mustela putorius furo	96.51	2.00e-164	571.00
IUUC-Mlu-067426	Myotis lucifugus	86.97	3.00e-145	507.00
IUUC-Nle-069772	Nomascus leucogenys	92.05	4.00e-159	553.00
IUUC-Ocu-074159	Oryctolagus cuniculus	86.12	4.00e-145	507.00
IUUC-Oga-088514	Otolemur garnettii	97.97	2.00e-166	578.00
IUUC-Oar-090406	Ovis aries	89.24	1.00e-164	572.00
IUUC-Ptr-091467	Pan troglodytes	99.42	9.00e-168	582.00
IUUC-Psi-093492	Pelodiscus sinensis	83.24	4.00e-154	537.00
IUUC-Pab-098045	Pongo abelii	93.66	1.00e-146	512.00
IUUC-Pca-100551	Procavia capensis	97.09	3.00e-165	574.00
IUUC-Pva-102686	Pteropus vampyrus	96.80	2.00e-165	575.00
IUUC-Rno-105679	Rattus norvegicus	95.91	5.00e-162	563.00
IUUC-Sha-107443	Sarcophilus harrisii	73.56	2.00e-136	478.00
IUUC-Ssc-115591	Sus scrofa	75.22	3.00e-139	488.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence